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Alpha-Lipoic Acid cho Oxidative Stress & Neuroinflammation

C

A universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.

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C

Kết luận

A universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.

Key Study Findings

In Vitro
Evaluation of the neuroprotective effects of alpha lipoic acid-loaded folate-conjugated chitosan nanoparticles against 6-OHDA-induced apoptosis …
Dose: None so với: free alpha-lipoic acid Outcome: neuroprotective efficacy against 6-OHDA-induced neurotoxicity Hiệu quả: None None

Đối tượng nghiên cứu: SH-SY5Y neuroblastoma cells with 6-OHDA-induced neurotoxicity (in vitro PD model)

Other 8 weeks
α-Lipoic acid mitigates age-related cognitive decline by modulating PPARγ/NF-κB-mediated neuroinflammation.
Dose: 100 mg/kg/day so với: untreated aged mice; D-galactose-induced senescent BV2 cells Outcome: cognitive function (T maze behavioral tests) Hiệu quả: None None

Đối tượng nghiên cứu: 18-month-old naturally aged C57BL/6 mice

Other
Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications.
Dose: 50, 100, and 200 mg/kg so với: sham-operated controls Outcome: mechanical and thermal hyperalgesia Hiệu quả: None None

Đối tượng nghiên cứu: mice with spinal nerve ligation-induced neuropathic pain

Other
Executive Summary of the Vulvodynia Therapeutic Research Summit.
Dose: None so với: None Outcome: None Hiệu quả: None None

Đối tượng nghiên cứu: expert consensus on therapeutics for provoked vestibulodynia

Other
α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via …
Dose: None so với: free alpha-lipoic acid and non-targeted nanoparticles Outcome: seizure-induced neurotoxicity and mitochondrial homeostasis Hiệu quả: None None

Đối tượng nghiên cứu: in vitro and in vivo epilepsy models

Controlled Clinical Trial n=24 4 weeks
Neuroprotective Effects of Alpha-Lipoic Acid Against Behavioral Toxicity, Oxidative and Inflammatory Damage Caused by Titanium …
Dose: ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p. so với: negative control, TiO2-NPs alone, ALA alone Outcome: neurobehavioral performance and neurodegeneration markers Hiệu quả: None None

Đối tượng nghiên cứu: male Sprague-Dawley rats

Key Statistics

8

Nghiên cứu

500

Người tham gia

Positive

C

Xếp hạng

Referenced Papers

Cellular physiology and … 2018 29 trích dẫn
International journal of … 2016 29 trích dẫn
Evidence-based complementary and … 2011 23 trích dẫn

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Liều lượng thường dùng

general:
300-600 mg/day
cognitivesupport:
600-1,200 mg/day (R-ALA preferred)

Giới hạn trên: 2,400 mg/day (highest dose in clinical trials)

Liều lượng đã nghiên cứu

Liều lượng Thời gian Hiệu quả N
None -- Positive --
100 mg/kg/day 8 weeks Positive --
50, 100, and 200 mg/kg -- Positive --
None -- Neutral --
None -- Positive --
ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p. 4 weeks Positive 24
None -- Positive --
None -- Positive --

Thời điểm dùng tốt nhất: On empty stomach; 30 minutes before meals

Safety & Side Effects

Tác dụng phụ đã được báo cáo

  • Gastrointestinal discomfort
  • Skin rash
  • Hypoglycemia (in diabetics)
  • Headache

Tương tác đã biết

  • Antidiabetic drugs (may enhance blood sugar lowering)
  • Thyroid medications (may affect thyroid hormone levels)
  • Chemotherapy agents (may reduce efficacy of some agents)

Mức hấp thụ tối đa cho phép: 2,400 mg/day (highest dose in clinical trials)

Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.

Frequently Asked Questions

Does Alpha-Lipoic Acid help with Oxidative Stress & Neuroinflammation?
Based on 8 studies with 500 participants, there is limited but promising evidence that Alpha-Lipoic Acid may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Alpha-Lipoic Acid should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Alpha-Lipoic Acid?
Reported side effects may include Gastrointestinal discomfort, Skin rash, Hypoglycemia (in diabetics), Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Alpha-Lipoic Acid and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

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