Alpha-Lipoic Acid per Oxidative Stress & Neuroinflammation

A universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.

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In sintesi

Key Study Findings

In Vitro

Evaluation of the neuroprotective effects of alpha lipoic acid-loaded folate-conjugated chitosan nanoparticles against 6-OHDA-induced apoptosis …

Dose: None vs: free alpha-lipoic acid Outcome: neuroprotective efficacy against 6-OHDA-induced neurotoxicity Effetto: None None

Popolazione: SH-SY5Y neuroblastoma cells with 6-OHDA-induced neurotoxicity (in vitro PD model)

Other 8 weeks

α-Lipoic acid mitigates age-related cognitive decline by modulating PPARγ/NF-κB-mediated neuroinflammation.

Dose: 100 mg/kg/day vs: untreated aged mice; D-galactose-induced senescent BV2 cells Outcome: cognitive function (T maze behavioral tests) Effetto: None None

Popolazione: 18-month-old naturally aged C57BL/6 mice

Other

Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications.

Dose: 50, 100, and 200 mg/kg vs: sham-operated controls Outcome: mechanical and thermal hyperalgesia Effetto: None None

Popolazione: mice with spinal nerve ligation-induced neuropathic pain

Other

Executive Summary of the Vulvodynia Therapeutic Research Summit.

Dose: None vs: None Outcome: None Effetto: None None

Popolazione: expert consensus on therapeutics for provoked vestibulodynia

Other

α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via …

Dose: None vs: free alpha-lipoic acid and non-targeted nanoparticles Outcome: seizure-induced neurotoxicity and mitochondrial homeostasis Effetto: None None

Popolazione: in vitro and in vivo epilepsy models

Controlled Clinical Trial n=24 4 weeks

Neuroprotective Effects of Alpha-Lipoic Acid Against Behavioral Toxicity, Oxidative and Inflammatory Damage Caused by Titanium …

Dose: ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p. vs: negative control, TiO2-NPs alone, ALA alone Outcome: neurobehavioral performance and neurodegeneration markers Effetto: None None

Popolazione: male Sprague-Dawley rats

Key Statistics

Studi

500

Partecipanti

↑

Positive

Grado

Referenced Papers

Neuroprotective Effects of Alpha-Lipoic Acid Against Behavioral Toxicity, Oxidative and Inflammatory Damage Caused by Titanium Dioxide Nanoparticles. Other

Biological trace element … 2026 2 citazioni

α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via the PINK1/Parkin pathway. Other

Free radical biology … 2026

Evaluation of the neuroprotective effects of alpha lipoic acid-loaded folate-conjugated chitosan nanoparticles against 6-OHDA-induced apoptosis and oxidative stress in an … Other

BMC neuroscience 2026

α-Lipoic acid mitigates age-related cognitive decline by modulating PPARγ/NF-κB-mediated neuroinflammation. Other

Experimental gerontology 2026

Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications. Other

Inflammopharmacology 2026

Executive Summary of the Vulvodynia Therapeutic Research Summit. Other

Obstetrics and gynecology 2026

Alpha-Lipoic Acid Reduces Neuroinflammation and Oxidative Stress Induced by Dapsone in an Animal Model. Other

Nutrients 2025 9 citazioni

Research progress on the role of oxidative stress in the pathogenesis of vascular dementia and its treatment. Review

Journal of stroke … 2025 4 citazioni

CMX-2043 Treatment Limits Neural Injury Pathophysiology and Promotes Neurological and Cognitive Recovery in a Pediatric Porcine Traumatic Brain Injury Model. Other

Journal of neurotrauma 2025

Neuroinflammation-Modulating Properties Combining Glutathione, N-Acetylcysteine, and Uridine Monophosphate in a Formulation Supplement: An In Vitro Study. Other

Brain sciences 2025

Neuroprotective effects of α-lipoic acid on ischemia/reperfusion injury in global cerebral ischemia mouse model. Other

Scientific reports 2025

Exploring the Role of Alpha Lipoic Acid in the Treatment of Traumatic Brain Injury: Pathways and Perspectives. Review

Neurocritical care 2025

Polymeric nanocomposite electrode for enhanced electrochemical detection of α-lipoic acid: Application in neuroinflammation prevention and clinical analysis. Other

Environmental research 2024 33 citazioni

Practical supplements for prevention and management of migraine attacks: a narrative review. Review

Frontiers in nutrition 2024 9 citazioni

Alpha-lipoic acid reduces nociception by reducing oxidative stress and neuroinflammation in a model of complex regional pain syndrome type I … Other

Behavioural brain research 2024 8 citazioni

Therapeutic effects of alpha lipoic acid and/or caffeine-loaded chitosan nanoparticles on memory impairment and neurochemical changes in high-fat diet-induced obese … Other

Physiology & behavior 2024 3 citazioni

Alpha-lipoic acid (ALA) ameliorates early brain injury after subarachnoid hemorrhage in Sprague-Dawley (SD) rats via inhibiting STING-NLRP3 inflammatory signaling. Other

Neuroreport 2024 3 citazioni

Alpha-Lipoic Acid Ameliorates Doxorubicin-Induced Cognitive Impairments by Modulating Neuroinflammation and Oxidative Stress via NRF-2/HO-1 Signaling Pathway in the Rat Hippocampus. Other

Neurochemical research 2023 15 citazioni

Remyelinating activities of Carvedilol or alpha lipoic acid in the Cuprizone-Induced rat model of demyelination. Other

International immunopharmacology 2023 9 citazioni

Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia. Other

Antioxidants (Basel, Switzerland) 2023 5 citazioni

Administration of α-lipoic acid and silymarin attenuates aggression by modulating endocrine, oxidative stress and inflammatory pathways in mice. Other

Metabolic brain disease 2023 4 citazioni

Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus. Other

Neuroscience letters 2023 4 citazioni

Neuroprotective Role of α-Lipoic Acid in Iron-Overload-Mediated Toxicity and Inflammation in In Vitro and In Vivo Models. Other

Antioxidants (Basel, Switzerland) 2022 22 citazioni

Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity. Other

Toxicology mechanisms and … 2022 16 citazioni

Alpha-lipoic acid improved motor function in MPTP-induced Parkinsonian mice by reducing neuroinflammation in the nigral and spinal cord. Other

Neuroscience letters 2022 16 citazioni

Alpha lipoic acid reverses scopolamine-induced spatial memory loss and pyramidal cell neurodegeneration in the prefrontal cortex of Wistar rats. Other

IBRO neuroscience reports 2022 11 citazioni

α-Lipoic Acid Reduces Ceramide Synthesis and Neuroinflammation in the Hypothalamus of Insulin-Resistant Rats, While in the Cerebral Cortex Diminishes the … Other

Journal of inflammation … 2022 9 citazioni

Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation. Other

The journal of … 2021 41 citazioni

Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex. Other

Metabolic brain disease 2021 24 citazioni

Macrophages and Schwann cell TRPA1 mediate chronic allodynia in a mouse model of complex regional pain syndrome type I. Other

Brain, behavior, and … 2020 58 citazioni

Nociception in a Progressive Multiple Sclerosis Model in Mice Is Dependent on Spinal TRPA1 Channel Activation. Other

Molecular neurobiology 2020 12 citazioni

Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation. Other

BMB reports 2019 29 citazioni

The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke. Other

Cellular physiology and … 2018 29 citazioni

Alpha-Lipoic Acid Preconditioning and Ischaemic Postconditioning Synergistically Protect Rats from Cerebral Injury Induced by Ischemia and Reperfusion Partly via Inhibition … Other

Cellular physiology and … 2018 27 citazioni

Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis. Other

Neurochemistry international 2017 53 citazioni

Cytotoxic Effects of Environmental Toxins on Human Glial Cells. Other

Neurotoxicity research 2017

Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease. Review

Neurochemistry international 2016 153 citazioni

Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease. Other

International journal of … 2016 29 citazioni

Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke. Other

Molecular neurobiology 2016 7 citazioni

[Use of alpha-lipoic acid and omega-3 in postpartum pain treatment]. Review

Minerva ginecologica 2015

α-Lipoic acid attenuates obesity-associated hippocampal neuroinflammation and increases the levels of brain-derived neurotrophic factor in ovariectomized rats fed a high-fat … Other

International journal of … 2013 29 citazioni

The Role of Th17 in Neuroimmune Disorders: Target for CAM Therapy. Part II. Other

Evidence-based complementary and … 2011 23 citazioni

Nutritional and exercise-based interventions in the treatment of amyotrophic lateral sclerosis. Review

Clinical nutrition (Edinburgh, … 2009 52 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 300-600 mg/day
cognitivesupport:: 600-1,200 mg/day (R-ALA preferred)

Limite massimo: 2,400 mg/day (highest dose in clinical trials)

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	--
100 mg/kg/day	8 weeks	Positive	--
50, 100, and 200 mg/kg	--	Positive	--
None	--	Neutral	--
None	--	Positive	--
ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p.	4 weeks	Positive	24
None	--	Positive	--
None	--	Positive	--

Momento migliore per l'assunzione: On empty stomach; 30 minutes before meals

Safety & Side Effects

Effetti collaterali segnalati

⚠ Gastrointestinal discomfort
⚠ Skin rash
⚠ Hypoglycemia (in diabetics)
⚠ Headache

Interazioni note

● Antidiabetic drugs (may enhance blood sugar lowering)
● Thyroid medications (may affect thyroid hormone levels)
● Chemotherapy agents (may reduce efficacy of some agents)

Livello di assunzione massimo tollerabile: 2,400 mg/day (highest dose in clinical trials)

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Alpha-Lipoic Acid help with Oxidative Stress & Neuroinflammation?

Based on 8 studies with 500 participants, there is limited but promising evidence that Alpha-Lipoic Acid may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).

How much Alpha-Lipoic Acid should I take for Oxidative Stress & Neuroinflammation?

Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Alpha-Lipoic Acid?

Reported side effects may include Gastrointestinal discomfort, Skin rash, Hypoglycemia (in diabetics), Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Alpha-Lipoic Acid and Oxidative Stress & Neuroinflammation?

We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Oxidative Stress & Neuroinflammation

Curcumin B N-Acetyl Cysteine B Green Tea Extract (EGCG) C Acetyl-L-Carnitine C Taurine C

Verdetto rapido

Evidence Strength52%

Moderate confidence

Analisi degli studi

RCT (0)Meta (0)Other (8)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

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Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.