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Alpha-Lipoic Acid для Oxidative Stress & Neuroinflammation

C

A universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.

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C

Итог

A universal antioxidant that regenerates vitamins C, E, and glutathione. Metal chelation reduces oxidative neuronal damage. Shows significant synergistic neuroprotective effects when combined with ALCAR.

Key Study Findings

In Vitro
Evaluation of the neuroprotective effects of alpha lipoic acid-loaded folate-conjugated chitosan nanoparticles against 6-OHDA-induced apoptosis …
Dose: None или: free alpha-lipoic acid Outcome: neuroprotective efficacy against 6-OHDA-induced neurotoxicity Эффект: None None

Популяция: SH-SY5Y neuroblastoma cells with 6-OHDA-induced neurotoxicity (in vitro PD model)

Other 8 weeks
α-Lipoic acid mitigates age-related cognitive decline by modulating PPARγ/NF-κB-mediated neuroinflammation.
Dose: 100 mg/kg/day или: untreated aged mice; D-galactose-induced senescent BV2 cells Outcome: cognitive function (T maze behavioral tests) Эффект: None None

Популяция: 18-month-old naturally aged C57BL/6 mice

Other
Efficacy of alpha-lipoic acid in mitigating neuropathic pain: mechanistic insights and therapeutic implications.
Dose: 50, 100, and 200 mg/kg или: sham-operated controls Outcome: mechanical and thermal hyperalgesia Эффект: None None

Популяция: mice with spinal nerve ligation-induced neuropathic pain

Other
Executive Summary of the Vulvodynia Therapeutic Research Summit.
Dose: None или: None Outcome: None Эффект: None None

Популяция: expert consensus on therapeutics for provoked vestibulodynia

Other
α-lipoic acid nanoparticles functionalized with RVG29 peptide attenuate seizure-induced neurotoxicity by restoring mitochondrial homeostasis via …
Dose: None или: free alpha-lipoic acid and non-targeted nanoparticles Outcome: seizure-induced neurotoxicity and mitochondrial homeostasis Эффект: None None

Популяция: in vitro and in vivo epilepsy models

Controlled Clinical Trial n=24 4 weeks
Neuroprotective Effects of Alpha-Lipoic Acid Against Behavioral Toxicity, Oxidative and Inflammatory Damage Caused by Titanium …
Dose: ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p. или: negative control, TiO2-NPs alone, ALA alone Outcome: neurobehavioral performance and neurodegeneration markers Эффект: None None

Популяция: male Sprague-Dawley rats

Key Statistics

8

Исследования

500

Участники

Positive

C

Оценка

Referenced Papers

Antioxidants (Basel, Switzerland) 2023 5 цитирований
Cellular physiology and … 2018 29 цитирований
International journal of … 2016 29 цитирований
Evidence-based complementary and … 2011 23 цитирований
Clinical nutrition (Edinburgh, … 2009 52 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
300-600 mg/day
cognitivesupport:
600-1,200 mg/day (R-ALA preferred)

Верхний предел: 2,400 mg/day (highest dose in clinical trials)

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Positive --
100 mg/kg/day 8 weeks Positive --
50, 100, and 200 mg/kg -- Positive --
None -- Neutral --
None -- Positive --
ALA 50 mg/kg orally; TiO2-NPs 150 mg/kg i.p. 4 weeks Positive 24
None -- Positive --
None -- Positive --

Лучшее время приёма: On empty stomach; 30 minutes before meals

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Gastrointestinal discomfort
  • Skin rash
  • Hypoglycemia (in diabetics)
  • Headache

Известные взаимодействия

  • Antidiabetic drugs (may enhance blood sugar lowering)
  • Thyroid medications (may affect thyroid hormone levels)
  • Chemotherapy agents (may reduce efficacy of some agents)

Допустимый верхний уровень потребления: 2,400 mg/day (highest dose in clinical trials)

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Alpha-Lipoic Acid help with Oxidative Stress & Neuroinflammation?
Based on 8 studies with 500 participants, there is limited but promising evidence that Alpha-Lipoic Acid may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Alpha-Lipoic Acid should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 300-600 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Alpha-Lipoic Acid?
Reported side effects may include Gastrointestinal discomfort, Skin rash, Hypoglycemia (in diabetics), Headache. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Alpha-Lipoic Acid and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Oxidative Stress & Neuroinflammation

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