Taurine для Oxidative Stress & Neuroinflammation
C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.
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C
Итог
Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.
Key Study Findings
Review
Taurine as an Early-Phase Disease-Modifying Candidate for Alzheimer's Disease.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: narrative review of taurine neuroprotective actions in Alzheimer's disease
Other
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of …
Dose: None
или: untreated 3xTg-AD mice
Outcome: metabolic coupling restoration (lactate-glutamate dynamics, taurine metabolism)
Эффект: None
None
Популяция: 6- and 12-month-old triple transgenic (3xTg-AD) Alzheimer's disease mice
Controlled Clinical Trial
6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day
или: ROFA exposure without taurine
Outcome: Multi-organ oxidative stress and neuroinflammation
Эффект: None
None
Популяция: Male Wistar rats with intranasal ROFA exposure
Other
n=70
Synergetic effect of taurine/taurine nanoparticles along with Sinemet® against rotenone-induced Parkinson's disease in mice.
Dose: None
или: Rotenone-induced PD model controls
Outcome: Neuroprotection in rotenone-induced PD mice
Эффект: None
None
Популяция: Rotenone-induced Parkinson's disease mice (10 groups)
Other
Taurine ameliorates viral encephalitis by restoring PRKN-mediated mitophagy.
Dose: None
или: HSV-1 infected cells/mice without taurine
Outcome: HSV-1 infection and viral encephalitis severity
Эффект: None
None
Популяция: HSV-1 viral encephalitis in vitro and mouse model
Other
4 weeks
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral …
Dose: 1000 mg/kg oral for 4 weeks
или: Vehicle control in 5XFAD mice
Outcome: Aβ accumulation, tau phosphorylation, neuroinflammation
Эффект: None
None
Популяция: 5XFAD AD mice and patient-derived cerebral organoids
Key Statistics
6
Исследования
300
Участники
↑
Positive
C
Оценка
Referenced Papers
International journal of …
2026
Biomedicine & pharmacotherapy …
2026
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2025
13 цитирований
Metabolic brain disease
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Autophagy
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Biomedicine & pharmacotherapy …
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The Journal of …
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NPJ Parkinson's disease
2024
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Journal of neuroinflammation
2024
42 цитирований
Molecular and cellular …
2024
13 цитирований
Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors.
Other
PloS one
2024
5 цитирований
Protective effects of taurine on heat Stress-Induced cognitive impairment through Npas4 and Lcn2.
Other
International immunopharmacology
2024
4 цитирований
Frontiers in medicine
2024
4 цитирований
Aging
2024
2 цитирований
Frontiers in aging
2023
76 цитирований
Food & function
2023
15 цитирований
BMC geriatrics
2023
12 цитирований
Chemistry & biodiversity
2023
6 цитирований
Frontiers in endocrinology
2022
52 цитирований
Scientific reports
2022
31 цитирований
Toxicological sciences : …
2022
29 цитирований
Journal of immunology …
2021
20 цитирований
GeroScience
2021
9 цитирований
Human gene therapy
2020
32 цитирований
Biomolecules
2020
28 цитирований
Life sciences
2019
110 цитирований
Amino acids
2018
50 цитирований
Journal of neurochemistry
2018
30 цитирований
Amino acids
2018
23 цитирований
Neurochemistry international
2017
56 цитирований
Alcohol (Fayetteville, N.Y.)
2015
122 цитирований
Frontiers in bioscience …
2015
62 цитирований
British journal of …
2014
111 цитирований
Food and chemical …
2014
102 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 500-2,000 mg/day
- cognitivesupport:
- 1,000-3,000 mg/day
Верхний предел: 3,000 mg/day (EFSA safety assessment)
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 400 mg/kg/day | 6 weeks | Mixed | -- |
| None | -- | Positive | 70 |
| None | -- | Positive | -- |
| 1000 mg/kg oral for 4 weeks | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
Лучшее время приёма: With or without food; may be calming if taken evening
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Generally very well-tolerated
- ⚠ Mild gastrointestinal discomfort (rare)
- ⚠ Drowsiness at high doses
Известные взаимодействия
- ● Antihypertensive drugs (additive blood pressure lowering)
- ● Antiepileptic drugs (may enhance GABA effects)
Допустимый верхний уровень потребления: 3,000 mg/day (EFSA safety assessment)
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Taurine help with Oxidative Stress & Neuroinflammation?
Based on 6 studies with 300 participants, there is limited but promising evidence that Taurine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally very well-tolerated, Mild gastrointestinal discomfort (rare), Drowsiness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Oxidative Stress & Neuroinflammation
References
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