Taurine para Oxidative Stress & Neuroinflammation
C Evidências Evidência limitada de estudos de pequena dimensão, mas existem alguns sinais positivos.Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.
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C
Conclusão
Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.
Key Study Findings
Review
Taurine as an Early-Phase Disease-Modifying Candidate for Alzheimer's Disease.
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: narrative review of taurine neuroprotective actions in Alzheimer's disease
Other
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of …
Dose: None
vs: untreated 3xTg-AD mice
Outcome: metabolic coupling restoration (lactate-glutamate dynamics, taurine metabolism)
Efeito: None
None
População: 6- and 12-month-old triple transgenic (3xTg-AD) Alzheimer's disease mice
Controlled Clinical Trial
6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day
vs: ROFA exposure without taurine
Outcome: Multi-organ oxidative stress and neuroinflammation
Efeito: None
None
População: Male Wistar rats with intranasal ROFA exposure
Other
n=70
Synergetic effect of taurine/taurine nanoparticles along with Sinemet® against rotenone-induced Parkinson's disease in mice.
Dose: None
vs: Rotenone-induced PD model controls
Outcome: Neuroprotection in rotenone-induced PD mice
Efeito: None
None
População: Rotenone-induced Parkinson's disease mice (10 groups)
Other
Taurine ameliorates viral encephalitis by restoring PRKN-mediated mitophagy.
Dose: None
vs: HSV-1 infected cells/mice without taurine
Outcome: HSV-1 infection and viral encephalitis severity
Efeito: None
None
População: HSV-1 viral encephalitis in vitro and mouse model
Other
4 weeks
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral …
Dose: 1000 mg/kg oral for 4 weeks
vs: Vehicle control in 5XFAD mice
Outcome: Aβ accumulation, tau phosphorylation, neuroinflammation
Efeito: None
None
População: 5XFAD AD mice and patient-derived cerebral organoids
Key Statistics
6
Estudos
300
Participantes
↑
Positive
C
Nota
Referenced Papers
International journal of …
2026
Biomedicine & pharmacotherapy …
2026
Journal of advanced …
2025
13 citações
Metabolic brain disease
2025
10 citações
Metabolic brain disease
2025
7 citações
Frontiers in nutrition
2025
7 citações
Asian Pacific journal …
2025
6 citações
Inflammation
2025
6 citações
Autophagy
2025
4 citações
Phytomedicine : international …
2025
3 citações
Biomedicine & pharmacotherapy …
2025
2 citações
Archives of pharmacal …
2025
1 citações
Toxicology mechanisms and …
2025
1 citações
Psychoneuroendocrinology
2025
1 citações
Research square
2025
The Journal of …
2025
Toxicology research
2025
Neurotoxicology
2025
NPJ Parkinson's disease
2024
57 citações
Journal of neuroinflammation
2024
42 citações
Molecular and cellular …
2024
13 citações
Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors.
Other
PloS one
2024
5 citações
Protective effects of taurine on heat Stress-Induced cognitive impairment through Npas4 and Lcn2.
Other
International immunopharmacology
2024
4 citações
Frontiers in medicine
2024
4 citações
Aging
2024
2 citações
Frontiers in aging
2023
76 citações
Food & function
2023
15 citações
BMC geriatrics
2023
12 citações
Chemistry & biodiversity
2023
6 citações
Frontiers in endocrinology
2022
52 citações
Scientific reports
2022
31 citações
Toxicological sciences : …
2022
29 citações
Journal of immunology …
2021
20 citações
GeroScience
2021
9 citações
Human gene therapy
2020
32 citações
Biomolecules
2020
28 citações
Life sciences
2019
110 citações
Amino acids
2018
50 citações
Journal of neurochemistry
2018
30 citações
Amino acids
2018
23 citações
Neurochemistry international
2017
56 citações
Alcohol (Fayetteville, N.Y.)
2015
122 citações
Frontiers in bioscience …
2015
62 citações
British journal of …
2014
111 citações
Food and chemical …
2014
102 citações
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 500-2,000 mg/day
- cognitivesupport:
- 1,000-3,000 mg/day
Limite superior: 3,000 mg/day (EFSA safety assessment)
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 400 mg/kg/day | 6 weeks | Mixed | -- |
| None | -- | Positive | 70 |
| None | -- | Positive | -- |
| 1000 mg/kg oral for 4 weeks | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
Melhor horário: With or without food; may be calming if taken evening
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Generally very well-tolerated
- ⚠ Mild gastrointestinal discomfort (rare)
- ⚠ Drowsiness at high doses
Interações Conhecidas
- ● Antihypertensive drugs (additive blood pressure lowering)
- ● Antiepileptic drugs (may enhance GABA effects)
Ingestão máxima tolerável: 3,000 mg/day (EFSA safety assessment)
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Taurine help with Oxidative Stress & Neuroinflammation?
Based on 6 studies with 300 participants, there is limited but promising evidence that Taurine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally very well-tolerated, Mild gastrointestinal discomfort (rare), Drowsiness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para Oxidative Stress & Neuroinflammation
References
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Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.