Taurine için Oxidative Stress & Neuroinflammation
C Kanıt Küçük çalışmalardan sınırlı kanıt mevcuttur, ancak bazı olumlu sinyaller bulunmaktadır.Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.
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C
Sonuç
Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.
Key Study Findings
Review
Taurine as an Early-Phase Disease-Modifying Candidate for Alzheimer's Disease.
Dose: None
vs: None
Outcome: None
Etki: None
None
Popülasyon: narrative review of taurine neuroprotective actions in Alzheimer's disease
Other
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of …
Dose: None
vs: untreated 3xTg-AD mice
Outcome: metabolic coupling restoration (lactate-glutamate dynamics, taurine metabolism)
Etki: None
None
Popülasyon: 6- and 12-month-old triple transgenic (3xTg-AD) Alzheimer's disease mice
Controlled Clinical Trial
6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day
vs: ROFA exposure without taurine
Outcome: Multi-organ oxidative stress and neuroinflammation
Etki: None
None
Popülasyon: Male Wistar rats with intranasal ROFA exposure
Other
n=70
Synergetic effect of taurine/taurine nanoparticles along with Sinemet® against rotenone-induced Parkinson's disease in mice.
Dose: None
vs: Rotenone-induced PD model controls
Outcome: Neuroprotection in rotenone-induced PD mice
Etki: None
None
Popülasyon: Rotenone-induced Parkinson's disease mice (10 groups)
Other
Taurine ameliorates viral encephalitis by restoring PRKN-mediated mitophagy.
Dose: None
vs: HSV-1 infected cells/mice without taurine
Outcome: HSV-1 infection and viral encephalitis severity
Etki: None
None
Popülasyon: HSV-1 viral encephalitis in vitro and mouse model
Other
4 weeks
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral …
Dose: 1000 mg/kg oral for 4 weeks
vs: Vehicle control in 5XFAD mice
Outcome: Aβ accumulation, tau phosphorylation, neuroinflammation
Etki: None
None
Popülasyon: 5XFAD AD mice and patient-derived cerebral organoids
Key Statistics
6
Çalışmalar
300
Katılımcılar
↑
Positive
C
Derece
Referenced Papers
International journal of …
2026
Biomedicine & pharmacotherapy …
2026
Journal of advanced …
2025
13 atıf
Metabolic brain disease
2025
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Metabolic brain disease
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Frontiers in nutrition
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Asian Pacific journal …
2025
6 atıf
Inflammation
2025
6 atıf
Autophagy
2025
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Phytomedicine : international …
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3 atıf
Biomedicine & pharmacotherapy …
2025
2 atıf
Archives of pharmacal …
2025
1 atıf
Toxicology mechanisms and …
2025
1 atıf
Psychoneuroendocrinology
2025
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Research square
2025
The Journal of …
2025
Toxicology research
2025
Neurotoxicology
2025
NPJ Parkinson's disease
2024
57 atıf
Journal of neuroinflammation
2024
42 atıf
Molecular and cellular …
2024
13 atıf
Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors.
Other
PloS one
2024
5 atıf
Protective effects of taurine on heat Stress-Induced cognitive impairment through Npas4 and Lcn2.
Other
International immunopharmacology
2024
4 atıf
Frontiers in medicine
2024
4 atıf
Aging
2024
2 atıf
Frontiers in aging
2023
76 atıf
Food & function
2023
15 atıf
BMC geriatrics
2023
12 atıf
Chemistry & biodiversity
2023
6 atıf
Frontiers in endocrinology
2022
52 atıf
Scientific reports
2022
31 atıf
Toxicological sciences : …
2022
29 atıf
Journal of immunology …
2021
20 atıf
GeroScience
2021
9 atıf
Human gene therapy
2020
32 atıf
Biomolecules
2020
28 atıf
Life sciences
2019
110 atıf
Amino acids
2018
50 atıf
Journal of neurochemistry
2018
30 atıf
Amino acids
2018
23 atıf
Neurochemistry international
2017
56 atıf
Alcohol (Fayetteville, N.Y.)
2015
122 atıf
Frontiers in bioscience …
2015
62 atıf
British journal of …
2014
111 atıf
Food and chemical …
2014
102 atıf
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Yaygın Kullanılan Dozajlar
- general:
- 500-2,000 mg/day
- cognitivesupport:
- 1,000-3,000 mg/day
Üst sınır: 3,000 mg/day (EFSA safety assessment)
Araştırmalarda İncelenen Dozajlar
| Dozaj | Süre | Etki | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 400 mg/kg/day | 6 weeks | Mixed | -- |
| None | -- | Positive | 70 |
| None | -- | Positive | -- |
| 1000 mg/kg oral for 4 weeks | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
En iyi alım zamanı: With or without food; may be calming if taken evening
Safety & Side Effects
Bildirilen Yan Etkiler
- ⚠ Generally very well-tolerated
- ⚠ Mild gastrointestinal discomfort (rare)
- ⚠ Drowsiness at high doses
Bilinen Etkileşimler
- ● Antihypertensive drugs (additive blood pressure lowering)
- ● Antiepileptic drugs (may enhance GABA effects)
Tolere edilebilir üst alım: 3,000 mg/day (EFSA safety assessment)
Herhangi bir takviye kullanmaya başlamadan önce mutlaka sağlık uzmanınıza danışın.Herhangi bir takviye başlatmadan önce her zaman sağlık uzmanınıza danışın.
Frequently Asked Questions
Does Taurine help with Oxidative Stress & Neuroinflammation?
Based on 6 studies with 300 participants, there is limited but promising evidence that Taurine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally very well-tolerated, Mild gastrointestinal discomfort (rare), Drowsiness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
Şu durum için diğer içerikler: Oxidative Stress & Neuroinflammation
References
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