Taurine cho Oxidative Stress & Neuroinflammation
C Bằng chứng Bằng chứng hạn chế từ các nghiên cứu nhỏ, nhưng có một số tín hiệu tích cực.Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'braincited.com';
const params = 'ingredient\u003Dtaurine\u0026condition\u003Doxidative\u002Dneuroinflammation';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
C
Kết luận
Research suggests taurine's anti-excitotoxic effects and neuronal calcium homeostasis support may help protect against oxidative neuronal damage. Preclinical evidence is strong; human cognitive trials are limited.
Key Study Findings
Review
Taurine as an Early-Phase Disease-Modifying Candidate for Alzheimer's Disease.
Dose: None
so với: None
Outcome: None
Hiệu quả: None
None
Đối tượng nghiên cứu: narrative review of taurine neuroprotective actions in Alzheimer's disease
Other
Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of …
Dose: None
so với: untreated 3xTg-AD mice
Outcome: metabolic coupling restoration (lactate-glutamate dynamics, taurine metabolism)
Hiệu quả: None
None
Đối tượng nghiên cứu: 6- and 12-month-old triple transgenic (3xTg-AD) Alzheimer's disease mice
Controlled Clinical Trial
6 weeks
Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac …
Dose: 400 mg/kg/day
so với: ROFA exposure without taurine
Outcome: Multi-organ oxidative stress and neuroinflammation
Hiệu quả: None
None
Đối tượng nghiên cứu: Male Wistar rats with intranasal ROFA exposure
Other
n=70
Synergetic effect of taurine/taurine nanoparticles along with Sinemet® against rotenone-induced Parkinson's disease in mice.
Dose: None
so với: Rotenone-induced PD model controls
Outcome: Neuroprotection in rotenone-induced PD mice
Hiệu quả: None
None
Đối tượng nghiên cứu: Rotenone-induced Parkinson's disease mice (10 groups)
Other
Taurine ameliorates viral encephalitis by restoring PRKN-mediated mitophagy.
Dose: None
so với: HSV-1 infected cells/mice without taurine
Outcome: HSV-1 infection and viral encephalitis severity
Hiệu quả: None
None
Đối tượng nghiên cứu: HSV-1 viral encephalitis in vitro and mouse model
Other
4 weeks
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral …
Dose: 1000 mg/kg oral for 4 weeks
so với: Vehicle control in 5XFAD mice
Outcome: Aβ accumulation, tau phosphorylation, neuroinflammation
Hiệu quả: None
None
Đối tượng nghiên cứu: 5XFAD AD mice and patient-derived cerebral organoids
Key Statistics
6
Nghiên cứu
300
Người tham gia
↑
Positive
C
Xếp hạng
Referenced Papers
International journal of …
2026
Biomedicine & pharmacotherapy …
2026
Journal of advanced …
2025
13 trích dẫn
Metabolic brain disease
2025
10 trích dẫn
Metabolic brain disease
2025
7 trích dẫn
Frontiers in nutrition
2025
7 trích dẫn
Asian Pacific journal …
2025
6 trích dẫn
Inflammation
2025
6 trích dẫn
Autophagy
2025
4 trích dẫn
Phytomedicine : international …
2025
3 trích dẫn
Biomedicine & pharmacotherapy …
2025
2 trích dẫn
Archives of pharmacal …
2025
1 trích dẫn
Toxicology mechanisms and …
2025
1 trích dẫn
Psychoneuroendocrinology
2025
1 trích dẫn
Research square
2025
The Journal of …
2025
Toxicology research
2025
Neurotoxicology
2025
NPJ Parkinson's disease
2024
57 trích dẫn
Journal of neuroinflammation
2024
42 trích dẫn
Molecular and cellular …
2024
13 trích dẫn
Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors.
Other
PloS one
2024
5 trích dẫn
Protective effects of taurine on heat Stress-Induced cognitive impairment through Npas4 and Lcn2.
Other
International immunopharmacology
2024
4 trích dẫn
Frontiers in medicine
2024
4 trích dẫn
Aging
2024
2 trích dẫn
Frontiers in aging
2023
76 trích dẫn
Food & function
2023
15 trích dẫn
BMC geriatrics
2023
12 trích dẫn
Chemistry & biodiversity
2023
6 trích dẫn
Frontiers in endocrinology
2022
52 trích dẫn
Scientific reports
2022
31 trích dẫn
Toxicological sciences : …
2022
29 trích dẫn
Journal of immunology …
2021
20 trích dẫn
GeroScience
2021
9 trích dẫn
Human gene therapy
2020
32 trích dẫn
Biomolecules
2020
28 trích dẫn
Life sciences
2019
110 trích dẫn
Amino acids
2018
50 trích dẫn
Journal of neurochemistry
2018
30 trích dẫn
Amino acids
2018
23 trích dẫn
Neurochemistry international
2017
56 trích dẫn
Alcohol (Fayetteville, N.Y.)
2015
122 trích dẫn
Frontiers in bioscience …
2015
62 trích dẫn
British journal of …
2014
111 trích dẫn
Food and chemical …
2014
102 trích dẫn
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Liều lượng thường dùng
- general:
- 500-2,000 mg/day
- cognitivesupport:
- 1,000-3,000 mg/day
Giới hạn trên: 3,000 mg/day (EFSA safety assessment)
Liều lượng đã nghiên cứu
| Liều lượng | Thời gian | Hiệu quả | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| 400 mg/kg/day | 6 weeks | Mixed | -- |
| None | -- | Positive | 70 |
| None | -- | Positive | -- |
| 1000 mg/kg oral for 4 weeks | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
Thời điểm dùng tốt nhất: With or without food; may be calming if taken evening
Safety & Side Effects
Tác dụng phụ đã được báo cáo
- ⚠ Generally very well-tolerated
- ⚠ Mild gastrointestinal discomfort (rare)
- ⚠ Drowsiness at high doses
Tương tác đã biết
- ● Antihypertensive drugs (additive blood pressure lowering)
- ● Antiepileptic drugs (may enhance GABA effects)
Mức hấp thụ tối đa cho phép: 3,000 mg/day (EFSA safety assessment)
Luôn tham khảo ý kiến bác sĩ trước khi bắt đầu sử dụng bất kỳ thực phẩm bổ sung nào.Luôn tham khảo ý kiến chuyên gia y tế trước khi sử dụng bất kỳ thực phẩm chức năng nào.
Frequently Asked Questions
Does Taurine help with Oxidative Stress & Neuroinflammation?
Based on 6 studies with 300 participants, there is limited but promising evidence that Taurine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is C (Some Evidence).
How much Taurine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Taurine?
Reported side effects may include Generally very well-tolerated, Mild gastrointestinal discomfort (rare), Drowsiness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Taurine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.
Related Evidence
Các thành phần khác cho Oxidative Stress & Neuroinflammation
References
- [1] Muhammad Kamal Hossain et al.. Int J Mol Sci. 2026. Taurine as an Early-Phase Disease-Modifying Candidate for Alzheimer's Disease. doi:10.3390/ijms27041871 PubMed
- [2] Roberta Facchinetti et al.. Biomed Pharmacother. 2026. Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer's disease. doi:10.1016/j.biopha.2025.118965 PubMed
- [3] Xiaowei Song et al.. J Adv Res. 2025. Inhibition of mitophagy via the EIF2S1-ATF4-PRKN pathway contributes to viral encephalitis. doi:10.1016/j.jare.2024.08.003 PubMed
- [4] Ahmad Raza et al.. Metab Brain Dis. 2025. From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer's disease. doi:10.1007/s11011-025-01700-z PubMed
- [5] Seyed Mehrad Razavi et al.. Metab Brain Dis. 2025. The effects of ursodeoxycholic acid on Parkinson's disease, a mechanistic review of the recent evidence. doi:10.1007/s11011-025-01542-9 PubMed
- [6] Apeksha Rana et al.. Front Nutr. 2025. Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies. doi:10.3389/fnut.2025.1534000 PubMed
- [7] Wanying Zhai et al.. Asian Pac J Allergy Immunol. 2025. Efficacy and associated neurotransmitters of digital cognitive behavior therapy for atopic dermatitis: A comparative effectiveness research. doi:10.12932/AP-100223-1542 PubMed
- [8] Meiling Yao et al.. Inflammation. 2025. LncRNA Tug1 Regulates Post-Stroke Microglial Pyroptosis via PINK1/Parkin-Mediated Mitophagy. doi:10.1007/s10753-024-02219-8 PubMed
- [9] Xiaowei Song et al.. Autophagy. 2025. Taurine ameliorates viral encephalitis by restoring PRKN-mediated mitophagy. doi:10.1080/15548627.2025.2538767 PubMed
- [10] Haixia Wang et al.. Phytomedicine. 2025. Daidzein alleviates chronic restraint stress-induced depression-like behavior by regulating neuroinflammation and synaptic plasticity via microbiota-gut-brain axis. doi:10.1016/j.phymed.2025.157394 PubMed
- [11] Hyewon Lee et al.. Biomed Pharmacother. 2025. Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral organoids. doi:10.1016/j.biopha.2025.118527 PubMed
- [12] Sung Min Moon et al.. Arch Pharm Res. 2025. Neuroprotective effects of taurine in a rodent model of parkinson's disease involve modulating astrocyte-mediated inflammation. doi:10.1007/s12272-025-01563-z PubMed
- [13] Doha M Beltagy et al.. Toxicol Mech Methods. 2025. Neuroprotective impacts of taurine nanoparticles against rotenone induced Parkinson's disease in mice. doi:10.1080/15376516.2025.2547874 PubMed
- [14] Bin Li et al.. Psychoneuroendocrinology. 2025. Transcriptomics study of hippocampus in mice exposed to heat stress. doi:10.1016/j.psyneuen.2025.107279 PubMed
- [15] Christina M Tognoni et al.. Res Sq. 2025. Protection of multiple aspects of Alzheimer's disease pathology using dietary supplementation with taurine. doi:10.21203/rs.3.rs-7483320/v1 PubMed
- [16] Alexander Shtilbans. J Nutr. 2025. Combination Supplement Therapy: A New Frontier in Treatment of Neurodegenerative Diseases. doi:10.1016/j.tjnut.2025.07.004 PubMed
- [17] Khaled M Elgindy et al.. Toxicol Res (Camb). 2025. Synergetic effect of taurine/taurine nanoparticles along with Sinemet® against rotenone-induced Parkinson's disease in mice. doi:10.1093/toxres/tfaf181 PubMed
- [18] Gedaias Noronha da Silva et al.. Neurotoxicology. 2025. Subchronic Residual Oil Fly Ash (ROFA) exposure induces oxidative stress in brain, lung, and cardiac tissues and promotes neuroinflammation, with … doi:10.1016/j.neuro.2025.103347 PubMed
- [19] Dayoon Kwon et al.. NPJ Parkinsons Dis. 2024. Diet and the gut microbiome in patients with Parkinson's disease. doi:10.1038/s41531-024-00681-7 PubMed
- [20] Shuang Chen et al.. J Neuroinflammation. 2024. Hypochlorous acid derived from microglial myeloperoxidase could mediate high-mobility group box 1 release from neurons to amplify brain damage in … doi:10.1186/s12974-023-02991-8 PubMed
- [21] Fernanda Huf et al.. Mol Cell Biochem. 2024. Neuroprotection elicited by taurine in sporadic Alzheimer-like disease: benefits on memory and control of neuroinflammation in the hippocampus of rats. doi:10.1007/s11010-023-04872-3 PubMed
- [22] Williams Kobik et al.. PLoS One. 2024. Energy drinks in Tamale: Understanding youth perceptions, consumption patterns, and related factors. doi:10.1371/journal.pone.0289391 PubMed
- [23] Bin Li et al.. Int Immunopharmacol. 2024. Protective effects of taurine on heat Stress-Induced cognitive impairment through Npas4 and Lcn2. doi:10.1016/j.intimp.2024.113376 PubMed
- [24] Cyriac Abby Philips. Front Med (Lausanne). 2024. Commonly encountered symptoms and their management in patients with cirrhosis. doi:10.3389/fmed.2024.1442525 PubMed
- [25] Yanling Li et al.. Aging (Albany NY). 2024. Jingfang granules protects against intracerebral hemorrhage by inhibiting neuroinflammation and protecting blood-brain barrier damage. doi:10.18632/aging.205854 PubMed
- [26] Samar F Darwish et al.. Front Aging. 2023. The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases. doi:10.3389/fragi.2023.1231706 PubMed
- [27] Xueqi Wang et al.. Food Funct. 2023. Transcriptomic and metabolomic analyses provide insights into the attenuation of neuroinflammation by nervonic acid in MPTP-stimulated PD model mice. doi:10.1039/d2fo02595g PubMed
- [28] Fu-Chao Liu et al.. BMC Geriatr. 2023. Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid metabolomics using liquid chromatography-tandem mass spectrometry. doi:10.1186/s12877-023-03939-6 PubMed
- [29] Dan-Dan Wu et al.. Chem Biodivers. 2023. UHPLC-Orbitrap-Fusion-TMS-Based Metabolomics Study of Phenylpropionamides in the Seed of Cannabis sativa L. against Alzheimer's Disease. doi:10.1002/cbdv.202201047 PubMed
- [30] Zhuan Lv et al.. Front Endocrinol (Lausanne). 2022. Acupuncture ameliorates breast cancer-related fatigue by regulating the gut microbiota-gut-brain axis. doi:10.3389/fendo.2022.921119 PubMed
- [31] Wouter Claeys et al.. Sci Rep. 2022. A mouse model of hepatic encephalopathy: bile duct ligation induces brain ammonia overload, glial cell activation and neuroinflammation. doi:10.1038/s41598-022-22423-6 PubMed
- [32] David Scieszka et al.. Toxicol Sci. 2022. Neuroinflammatory and Neurometabolomic Consequences From Inhaled Wildfire Smoke-Derived Particulate Matter in the Western United States. doi:10.1093/toxsci/kfab147 PubMed
- [33] Samara P Silva et al.. J Immunol Res. 2021. Neuroprotective Effect of Taurine against Cell Death, Glial Changes, and Neuronal Loss in the Cerebellum of Rats Exposed to Chronic-Recurrent … doi:10.1155/2021/7497185 PubMed
- [34] Jason J Paris et al.. Geroscience. 2021. In vivo proton magnetic resonance spectroscopy detection of metabolite abnormalities in aged Tat-transgenic mouse brain. doi:10.1007/s11357-021-00354-w PubMed
- [35] Kaihua Zhai et al.. Hum Gene Ther. 2020. Long-Noncoding RNA TUG1 Promotes Parkinson's Disease via Modulating MiR-152-3p/PTEN Pathway. doi:10.1089/hum.2020.106 PubMed
- [36] Mujtaba Aamir Bhat et al.. Biomolecules. 2020. Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases. doi:10.3390/biom10060863 PubMed
- [37] Chaoran Chen et al.. Life Sci. 2019. Roles of taurine in cognitive function of physiology, pathologies and toxication. doi:10.1016/j.lfs.2019.116584 PubMed
- [38] Hengli Zhao et al.. Amino Acids. 2018. Taurine supplementation reduces neuroinflammation and protects against white matter injury after intracerebral hemorrhage in rats. doi:10.1007/s00726-017-2529-8 PubMed
- [39] Aisling Chaney et al.. J Neurochem. 2018. Longitudinal investigation of neuroinflammation and metabolite profiles in the APPswe ×PS1Δe9 transgenic mouse model of Alzheimer's disease. doi:10.1111/jnc.14251 PubMed
- [40] Greice Caletti et al.. Amino Acids. 2018. Taurine counteracts the neurotoxic effects of streptozotocin-induced diabetes in rats. doi:10.1007/s00726-017-2495-1 PubMed
- [41] K H Reeta et al.. Neurochem Int. 2017. Chronic treatment with taurine after intracerebroventricular streptozotocin injection improves cognitive dysfunction in rats by modulating oxidative stress, cholinergic functions and … doi:10.1016/j.neuint.2017.03.006 PubMed
- [42] Kirk J Brower. Alcohol. 2015. Assessment and treatment of insomnia in adult patients with alcohol use disorders. doi:10.1016/j.alcohol.2014.12.003 PubMed
- [43] Roberta J Ward et al.. Front Biosci (Schol Ed). 2015. Ageing, neuroinflammation and neurodegeneration. doi:10.2741/S433 PubMed
- [44] Nicola J Kalk et al.. Br J Clin Pharmacol. 2014. The clinical pharmacology of acamprosate. doi:10.1111/bcp.12070 PubMed
- [45] Can Ali Agca et al.. Food Chem Toxicol. 2014. Taurine ameliorates neuropathy via regulating NF-κB and Nrf2/HO-1 signaling cascades in diabetic rats. doi:10.1016/j.fct.2014.05.023 PubMed
Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.