Curcumin 用于 Oxidative Stress & Neuroinflammation
BResearch suggests curcumin exhibits potent anti-neuroinflammatory effects, stimulates hippocampal neurogenesis, and upregulates BDNF. Enhanced bioavailability formulations are required for meaningful brain penetration.
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B
结论
Research suggests curcumin exhibits potent anti-neuroinflammatory effects, stimulates hippocampal neurogenesis, and upregulates BDNF. Enhanced bioavailability formulations are required for meaningful brain penetration.
Key Study Findings
Review
Drug delivery strategies for neuroprotective therapy in ischemic stroke: Application of nanotechnology.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
Neuropharmacology of synaptic plasticity: pathways to cognitive resilience in healthy aging.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: aging individuals with cognitive decline
In Vitro
Curcumin Alleviates Microglia-Mediated Neuroinflammation and Neuronal Ferroptosis Following Experimental Subarachnoid Hemorrhage by Modulating the Nrf2/HO-1 …
Dose: None
vs: SAH model mice
Outcome: Neuronal ferroptosis and neuroinflammation
效果: None
None
研究人群: SAH murine model
In Vitro
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation-Associated Microglial Response.
Dose: None
vs: None
Outcome: RNA m6A modification and neuroinflammation
效果: None
None
研究人群: Microglial cells post-epileptic seizures
Review
Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Review
The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation-A Narrative Review.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
Key Statistics
15
研究数量
1200
受试者
↑
Positive
B
等级
Referenced Papers
Neural regeneration research
2026
5 次引用
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2025
125 次引用
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16 次引用
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15 次引用
Biomedicines
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14 次引用
Nutrients
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11 次引用
Nutrients
2025
10 次引用
Nutrients
2025
10 次引用
European journal of …
2025
10 次引用
Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models.
Systematic Review
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7 次引用
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66 次引用
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52 次引用
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42 次引用
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41 次引用
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40 次引用
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2024
29 次引用
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2024
22 次引用
International journal of …
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20 次引用
Materials today. Bio
2024
18 次引用
Nanoencapsulated Curcumin: Enhanced Efficacy in Reversing Memory Loss in An Alzheimer Disease Model.
Other
Brain sciences
2024
14 次引用
Molecules (Basel, Switzerland)
2024
13 次引用
Neurochemistry international
2024
13 次引用
Ecotoxicology and environmental …
2024
7 次引用
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2024
6 次引用
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2023
151 次引用
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2023
76 次引用
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2023
47 次引用
International journal of …
2023
45 次引用
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2023
40 次引用
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2023
31 次引用
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2023
24 次引用
Phytomedicine : international …
2023
15 次引用
Current neurovascular research
2023
10 次引用
Neuropeptides
2023
8 次引用
Frontiers in cellular …
2022
91 次引用
Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation.
Review
Molecules (Basel, Switzerland)
2022
39 次引用
Pharmacological considerations for treating neuroinflammation with curcumin in Alzheimer's disease.
Review
Journal of neural …
2022
21 次引用
Biochemistry and cell …
2022
20 次引用
The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation.
Review
Neurochemical research
2022
13 次引用
Behavioral neuroscience
2022
2 次引用
The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota.
Review
Nutrients
2021
117 次引用
Neural regeneration research
2020
152 次引用
European journal of …
2020
91 次引用
Brain research bulletin
2020
58 次引用
Brain sciences
2020
40 次引用
Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway.
Review
Journal of neuroinflammation
2019
432 次引用
Molecular immunology
2019
383 次引用
Neurotoxicity research
2019
78 次引用
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2019
33 次引用
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2019
20 次引用
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2017
215 次引用
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2017
104 次引用
Journal of Alzheimer's …
2017
52 次引用
Neurochemistry international
2016
153 次引用
Current topics in …
2016
111 次引用
Neural regeneration research
2015
161 次引用
BioMed research international
2014
108 次引用
Neurotoxicity research
2013
246 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 500-2,000 mg/day of enhanced bioavailability form
- cognitivesupport:
- 90-180 mg/day Theracurmin or equivalent
上限： Well-tolerated up to 8,000 mg/day; 12,000 mg/day short-term
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 30 ug/body, 4 injections over 30 days | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
最佳服用时间： With meals containing fat and black pepper (piperine) for absorption
Safety & Side Effects
已报告的副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Skin rash (rare)
- ⚠ Yellow staining of teeth with powder forms
已知相互作用
- ● Anticoagulants (may increase bleeding risk)
- ● Antidiabetic drugs (may enhance blood sugar lowering)
- ● CYP450 substrates (may affect drug metabolism)
- ● Iron supplements (curcumin may chelate iron)
可耐受最高摄入量： Well-tolerated up to 8,000 mg/day; 12,000 mg/day short-term
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Curcumin help with Oxidative Stress & Neuroinflammation?
Based on 15 studies with 1,200 participants, there is moderate evidence from clinical studies that Curcumin may support Oxidative Stress & Neuroinflammation management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day of enhanced bioavailability form. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Skin rash (rare), Yellow staining of teeth with powder forms. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 Oxidative Stress & Neuroinflammation
Curcumin 用于其他健康状况
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