Curcumin ： Oxidative Stress & Neuroinflammation

References

1. [1] Zhan Jiang et al.. Neural Regen Res. 2026. Drug delivery strategies for neuroprotective therapy in ischemic stroke: Application of nanotechnology. doi:10.4103/NRR.NRR-D-24-01383 PubMed
2. [2] Falguni Goel et al.. 3 Biotech. 2026. Neuropharmacology of synaptic plasticity: pathways to cognitive resilience in healthy aging. doi:10.1007/s13205-025-04673-z PubMed
3. [3] Leilei Chen et al.. Signal Transduct Target Ther. 2025. Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases. doi:10.1038/s41392-024-02071-0 PubMed
4. [4] Yao Xu et al.. Mol Neurobiol. 2025. Curcumin Alleviates Microglia-Mediated Neuroinflammation and Neuronal Ferroptosis Following Experimental Subarachnoid Hemorrhage by Modulating the Nrf2/HO-1 Signaling Pathway. doi:10.1007/s12035-024-04443-7 PubMed
5. [5] Ninan Zhang et al.. Adv Sci (Weinh). 2025. Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation-Associated Microglial Response. doi:10.1002/advs.202405263 PubMed
6. [6] Ana Clara Figueiredo Godoy et al.. Biomedicines. 2025. Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora. doi:10.3390/biomedicines13051129 PubMed
7. [7] Andrea Lehoczki et al.. Nutrients. 2025. The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation-A Narrative Review. doi:10.3390/nu17172884 PubMed
8. [8] Miriam Cerullo et al.. Nutrients. 2025. Curcumin Modulation of the Gut-Brain Axis for Neuroinflammation and Metabolic Disorders Prevention and Treatment. doi:10.3390/nu17091430 PubMed
9. [9] Mahsa Yavari et al.. Nutrients. 2025. Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty Acids. doi:10.3390/nu17071203 PubMed
10. [10] Mohammad-Ali Bashirrohelleh et al.. Eur J Pharmacol. 2025. Curcumin-enhanced stem cell exosomes: A novel approach to modulating neuroinflammation and improving cognitive function in a rat model of Alzheimer's … doi:10.1016/j.ejphar.2025.177695 PubMed
11. [11] Samuel Abiodun Kehinde et al.. Int J Mol Sci. 2025. Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models. doi:10.3390/ijms26147026 PubMed
12. [12] Brandon Lucke-Wold et al.. Nutr Neurosci. 2025. Supplement and nutraceutical therapy in traumatic brain injury. doi:10.1080/1028415X.2024.2404782 PubMed
13. [13] Kaiqi Zhang et al.. Redox Biol. 2025. p53 promote oxidative stress, neuroinflammation and behavioral disorders via DDIT4-NF-κB signaling pathway. doi:10.1016/j.redox.2025.103836 PubMed
14. [14] Guifei Chen et al.. Food Sci Nutr. 2025. Polyphenols and Alzheimer's Disease: A Review on Molecular and Therapeutic Insights With In Silico Support. doi:10.1002/fsn3.70496 PubMed
15. [15] Ki-Yeon Yoo et al.. Biology (Basel). 2025. Therapeutic Potential of Natural Compounds for Brain Ischemia-Reperfusion Injury. doi:10.3390/biology14091153 PubMed
16. [16] Wenhui Liu et al.. Ecotoxicol Environ Saf. 2025. Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits. doi:10.1016/j.ecoenv.2025.119187 PubMed
17. [17] Krishn Kumar Agrawal et al.. Cent Nerv Syst Agents Med Chem. 2025. Lead Phytomolecules for Treating Parkinson's Disease. doi:10.2174/0118715249355503241210101001 PubMed
18. [18] Alexander Shtilbans. J Nutr. 2025. Combination Supplement Therapy: A New Frontier in Treatment of Neurodegenerative Diseases. doi:10.1016/j.tjnut.2025.07.004 PubMed
19. [19] Jemema Agnes Tripena Raj et al.. Brain Res. 2025. RAGE signaling pathway in glioblastoma and cognitive decline: Insights into inflammatory mechanisms and therapeutic implications. doi:10.1016/j.brainres.2025.150026 PubMed
20. [20] Long Chen et al.. Phytother Res. 2025. Natural Products and Exercise Synergy: Unraveling Molecular Mechanisms to Enhance Brain Function in Alzheimer's Disease. doi:10.1002/ptr.70005 PubMed
21. [21] Nasser M Aldekhail et al.. Altern Ther Health Med. 2025. Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines. PubMed
22. [22] Ziwei Lan et al.. Phytomedicine. 2024. Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization. doi:10.1016/j.phymed.2024.155635 PubMed
23. [23] Elena Azzini et al.. Phytother Res. 2024. Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies. doi:10.1002/ptr.8200 PubMed
24. [24] Prabhash Nath Tripathi et al.. Degener Neurol Neuromuscul Dis. 2024. Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants. doi:10.2147/DNND.S452009 PubMed
25. [25] Qianhua Feng et al.. Small. 2024. Intranasal Delivery of Pure Nanodrug Loaded Liposomes for Alzheimer's Disease Treatment by Efficiently Regulating Microglial Polarization. doi:10.1002/smll.202405781 PubMed
26. [26] Tiago Nicoliche et al.. Sci Rep. 2024. Antiviral, anti-inflammatory and antioxidant effects of curcumin and curcuminoids in SH-SY5Y cells infected by SARS-CoV-2. doi:10.1038/s41598-024-61662-7 PubMed
27. [27] JinJin Pei et al.. Ageing Res Rev. 2024. Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review. doi:10.1016/j.arr.2024.102393 PubMed
28. [28] Yoonsu Kim et al.. Biomed Pharmacother. 2024. Taming neuroinflammation in Alzheimer's disease: The protective role of phytochemicals through the gut-brain axis. doi:10.1016/j.biopha.2024.117277 PubMed
29. [29] Zhihan Chen et al.. Chin Med. 2024. A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer's disease based on the neuroinflammatory. doi:10.1186/s13020-024-00900-6 PubMed
30. [30] Zhongxin Duan et al.. Small Methods. 2024. Intranasal Delivery of Curcumin Nanoparticles Improves Neuroinflammation and Neurological Deficits in Mice with Intracerebral Hemorrhage. doi:10.1002/smtd.202400304 PubMed
31. [31] Qinglu Yang et al.. Int J Nanomedicine. 2024. Curcumin-Loaded Gelatin Nanoparticles Cross the Blood-Brain Barrier to Treat Ischemic Stroke by Attenuating Oxidative Stress and Neuroinflammation. doi:10.2147/IJN.S487628 PubMed
32. [32] Chunming Tang et al.. Mater Today Bio. 2024. A biomimic anti-neuroinflammatory nanoplatform for active neutrophil extracellular traps targeting and spinal cord injury therapy. doi:10.1016/j.mtbio.2024.101218 PubMed
33. [33] Anne Suély Pinto Savall et al.. Brain Sci. 2024. Nanoencapsulated Curcumin: Enhanced Efficacy in Reversing Memory Loss in An Alzheimer Disease Model. doi:10.3390/brainsci14020130 PubMed
34. [34] Bianca Sânziana Daraban et al.. Molecules. 2024. Latest Perspectives on Alzheimer's Disease Treatment: The Role of Blood-Brain Barrier and Antioxidant-Based Drug Delivery Systems. doi:10.3390/molecules29174056 PubMed
35. [35] Valeria Perales-Salinas et al.. Neurochem Int. 2024. Curcumin as a potential therapeutic agent for treating neurodegenerative diseases. doi:10.1016/j.neuint.2024.105790 PubMed
36. [36] Yuyan Chen et al.. Ecotoxicol Environ Saf. 2024. Noise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment. doi:10.1016/j.ecoenv.2024.117411 PubMed
37. [37] Fei Guo et al.. J Nanobiotechnology. 2024. Role of PCBP2 in regulating nanovesicles loaded with curcumin to mitigate neuroferroptosis in neural damage caused by heat stroke. doi:10.1186/s12951-024-02889-4 PubMed
38. [38] Mobina Amanollahi et al.. Mol Neurobiol. 2023. The Dialogue Between Neuroinflammation and Adult Neurogenesis: Mechanisms Involved and Alterations in Neurological Diseases. doi:10.1007/s12035-022-03102-z PubMed
39. [39] Samar F Darwish et al.. Front Aging. 2023. The dual face of microglia (M1/M2) as a potential target in the protective effect of nutraceuticals against neurodegenerative diseases. doi:10.3389/fragi.2023.1231706 PubMed
40. [40] Prachi Garodia et al.. Integr Med Res. 2023. Curcumin, inflammation, and neurological disorders: How are they linked? doi:10.1016/j.imr.2023.100968 PubMed
41. [41] Davide Decandia et al.. Int J Mol Sci. 2023. Dietary Protection against Cognitive Impairment, Neuroinflammation and Oxidative Stress in Alzheimer's Disease Animal Models of Lipopolysaccharide-Induced Inflammation. doi:10.3390/ijms24065921 PubMed
42. [42] Tarek Benameur et al.. Molecules. 2023. The Effects of Curcumin on Inflammasome: Latest Update. doi:10.3390/molecules28020742 PubMed
43. [43] Hamid Mostafavi Abdolmaleky et al.. Nutrients. 2023. Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals. doi:10.3390/nu15153456 PubMed
44. [44] Sagarika Majhi et al.. CNS Neurol Disord Drug Targets. 2023. A Review on Autism Spectrum Disorder: Pathogenesis, Biomarkers, Pharmacological and Non-Pharmacological Interventions. doi:10.2174/1871527321666220428134802 PubMed
45. [45] Yuan Chen et al.. Phytomedicine. 2023. Fucoxanthin, a marine derived carotenoid, attenuates surgery-induced cognitive impairments via activating Akt and ERK pathways in aged mice. doi:10.1016/j.phymed.2023.155043 PubMed
46. [46] Bing Chen et al.. Curr Neurovasc Res. 2023. Curcumin Alleviates Oxidative Stress, Neuroinflammation, and Promotes Behavioral Recovery After Traumatic Brain Injury. doi:10.2174/1567202620666230303144323 PubMed
47. [47] Mohammad Abbas Sheikholeslami et al.. Neuropeptides. 2023. Curcumin attenuates morphine dependence by modulating μ-opioid receptors and glial cell-activated neuroinflammation in rat. doi:10.1016/j.npep.2022.102318 PubMed
48. [48] Can Cui et al.. Front Cell Infect Microbiol. 2022. Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson's disease. doi:10.3389/fcimb.2022.887407 PubMed
49. [49] Antonia Cianciulli et al.. Molecules. 2022. Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation. doi:10.3390/molecules27020341 PubMed
50. [50] Xian Zhou et al.. J Neural Transm (Vienna). 2022. Pharmacological considerations for treating neuroinflammation with curcumin in Alzheimer's disease. doi:10.1007/s00702-022-02480-x PubMed
51. [51] Fei Wang et al.. Biochem Cell Biol. 2022. Curcumin attenuates intracerebral hemorrhage-induced neuronal apoptosis and neuroinflammation by suppressing JAK1/STAT1 pathway. doi:10.1139/bcb-2021-0423 PubMed
52. [52] Faheem Ullah et al.. Neurochem Res. 2022. The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation. doi:10.1007/s11064-021-03499-4 PubMed
53. [53] Ajay Uprety et al.. Behav Neurosci. 2022. Curcumin improves reversal learning in middle-aged rhesus monkeys. doi:10.1037/bne0000497 PubMed
54. [54] Friedrich Leblhuber et al.. Nutrients. 2021. The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota. doi:10.3390/nu13020361 PubMed
55. [55] Aurel Popa-Wagner et al.. Neural Regen Res. 2020. Dietary habits, lifestyle factors and neurodegenerative diseases. doi:10.4103/1673-5374.266045 PubMed
56. [56] Danica Michaličková et al.. Eur J Pharmacol. 2020. Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis. doi:10.1016/j.ejphar.2020.172973 PubMed
57. [57] Guangchi Sun et al.. Brain Res Bull. 2020. Curcumin alleviates neuroinflammation, enhances hippocampal neurogenesis, and improves spatial memory after traumatic brain injury. doi:10.1016/j.brainresbull.2020.05.009 PubMed
58. [58] Mahitab Farghali et al.. Brain Sci. 2020. Can Brain Health Be Supported by Vitamin D-Based Supplements? A Critical Review. doi:10.3390/brainsci10090660 PubMed
59. [59] Morena Zusso et al.. J Neuroinflammation. 2019. Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway. doi:10.1186/s12974-019-1538-9 PubMed
60. [60] Jiawei Zhang et al.. Mol Immunol. 2019. Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells. doi:10.1016/j.molimm.2019.09.020 PubMed
61. [61] Faezeh Ghasemi et al.. Neurotox Res. 2019. Effects of Curcumin on Microglial Cells. doi:10.1007/s12640-019-00030-0 PubMed
62. [62] Seyed Mohammad Nabavi et al.. Pharmacol Res. 2019. Targeting STATs in neuroinflammation: The road less traveled! doi:10.1016/j.phrs.2018.12.004 PubMed
63. [63] Yousef Tizabi et al.. Prog Mol Biol Transl Sci. 2019. Novel targets for parkinsonism-depression comorbidity. doi:10.1016/bs.pmbts.2019.06.004 PubMed
64. [64] Shibu M Poulose et al.. Adv Nutr. 2017. Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function. doi:10.3945/an.117.016261 PubMed
65. [65] Faheem Ullah et al.. Arch Toxicol. 2017. High bioavailability curcumin: an anti-inflammatory and neurosupportive bioactive nutrient for neurodegenerative diseases characterized by chronic neuroinflammation. doi:10.1007/s00204-017-1939-4 PubMed
66. [66] Amira Zaky et al.. J Alzheimers Dis. 2017. A Combination of Resveratrol and Curcumin is Effective Against Aluminum Chloride-Induced Neuroinflammation in Rats. doi:10.3233/JAD-161115 PubMed
67. [67] Madhuri Venigalla et al.. Neurochem Int. 2016. Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease. doi:10.1016/j.neuint.2015.10.011 PubMed
68. [68] Carmela Spagnuolo et al.. Curr Top Med Chem. 2016. Neuroprotective Role of Natural Polyphenols. doi:10.2174/1568026616666160204122449 PubMed
69. [69] Madhuri Venigalla et al.. Neural Regen Res. 2015. Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease. doi:10.4103/1673-5374.162686 PubMed
70. [70] Christopher Millington et al.. Biomed Res Int. 2014. Chronic neuroinflammation in Alzheimer's disease: new perspectives on animal models and promising candidate drugs. doi:10.1155/2014/309129 PubMed
71. [71] Laura L Hurley et al.. Neurotox Res. 2013. Neuroinflammation, neurodegeneration, and depression. doi:10.1007/s12640-012-9348-1 PubMed