Curcumin ： Oxidative Stress & Neuroinflammation
BResearch suggests curcumin exhibits potent anti-neuroinflammatory effects, stimulates hippocampal neurogenesis, and upregulates BDNF. Enhanced bioavailability formulations are required for meaningful brain penetration.
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B
結論
Research suggests curcumin exhibits potent anti-neuroinflammatory effects, stimulates hippocampal neurogenesis, and upregulates BDNF. Enhanced bioavailability formulations are required for meaningful brain penetration.
Key Study Findings
Review
Drug delivery strategies for neuroprotective therapy in ischemic stroke: Application of nanotechnology.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Neuropharmacology of synaptic plasticity: pathways to cognitive resilience in healthy aging.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: aging individuals with cognitive decline
In Vitro
Curcumin Alleviates Microglia-Mediated Neuroinflammation and Neuronal Ferroptosis Following Experimental Subarachnoid Hemorrhage by Modulating the Nrf2/HO-1 …
Dose: None
vs: SAH model mice
Outcome: Neuronal ferroptosis and neuroinflammation
効果: None
None
対象集団: SAH murine model
In Vitro
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation-Associated Microglial Response.
Dose: None
vs: None
Outcome: RNA m6A modification and neuroinflammation
効果: None
None
対象集団: Microglial cells post-epileptic seizures
Review
Neuroinflammation and Natural Antidepressants: Balancing Fire with Flora.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
The Neuroprotective Role of Curcumin: From Molecular Pathways to Clinical Translation-A Narrative Review.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Key Statistics
15
研究数
1200
参加者数
↑
Positive
B
グレード
Referenced Papers
Neural regeneration research
2026
5 件の引用
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2 件の引用
Signal transduction and …
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125 件の引用
Molecular neurobiology
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16 件の引用
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15 件の引用
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14 件の引用
Nutrients
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11 件の引用
Nutrients
2025
10 件の引用
Nutrients
2025
10 件の引用
European journal of …
2025
10 件の引用
Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models.
Systematic Review
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2025
7 件の引用
Nutritional neuroscience
2025
6 件の引用
Redox biology
2025
4 件の引用
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4 件の引用
Biology
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22 件の引用
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20 件の引用
Materials today. Bio
2024
18 件の引用
Nanoencapsulated Curcumin: Enhanced Efficacy in Reversing Memory Loss in An Alzheimer Disease Model.
Other
Brain sciences
2024
14 件の引用
Molecules (Basel, Switzerland)
2024
13 件の引用
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2024
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7 件の引用
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2023
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Integrative medicine research
2023
47 件の引用
International journal of …
2023
45 件の引用
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2023
40 件の引用
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2023
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2023
24 件の引用
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2023
15 件の引用
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2023
10 件の引用
Neuropeptides
2023
8 件の引用
Frontiers in cellular …
2022
91 件の引用
Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation.
Review
Molecules (Basel, Switzerland)
2022
39 件の引用
Pharmacological considerations for treating neuroinflammation with curcumin in Alzheimer's disease.
Review
Journal of neural …
2022
21 件の引用
Biochemistry and cell …
2022
20 件の引用
The Effects of Modified Curcumin Preparations on Glial Morphology in Aging and Neuroinflammation.
Review
Neurochemical research
2022
13 件の引用
Behavioral neuroscience
2022
2 件の引用
The Immunopathogenesis of Alzheimer's Disease Is Related to the Composition of Gut Microbiota.
Review
Nutrients
2021
117 件の引用
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2020
152 件の引用
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2020
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2020
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2020
40 件の引用
Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway.
Review
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2019
432 件の引用
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2019
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2019
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2019
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2017
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Neurochemistry international
2016
153 件の引用
Current topics in …
2016
111 件の引用
Neural regeneration research
2015
161 件の引用
BioMed research international
2014
108 件の引用
Neurotoxicity research
2013
246 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-2,000 mg/day of enhanced bioavailability form
- cognitivesupport:
- 90-180 mg/day Theracurmin or equivalent
上限量： Well-tolerated up to 8,000 mg/day; 12,000 mg/day short-term
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| 30 ug/body, 4 injections over 30 days | 4 weeks | Positive | -- |
| None | -- | Mixed | -- |
推奨摂取タイミング： With meals containing fat and black pepper (piperine) for absorption
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Skin rash (rare)
- ⚠ Yellow staining of teeth with powder forms
既知の相互作用
- ● Anticoagulants (may increase bleeding risk)
- ● Antidiabetic drugs (may enhance blood sugar lowering)
- ● CYP450 substrates (may affect drug metabolism)
- ● Iron supplements (curcumin may chelate iron)
耐容上限摂取量： Well-tolerated up to 8,000 mg/day; 12,000 mg/day short-term
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Curcumin help with Oxidative Stress & Neuroinflammation?
Based on 15 studies with 1,200 participants, there is moderate evidence from clinical studies that Curcumin may support Oxidative Stress & Neuroinflammation management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day of enhanced bioavailability form. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Skin rash (rare), Yellow staining of teeth with powder forms. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 15 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Oxidative Stress & Neuroinflammation
Curcumin 他の症状・状態について
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