What is the recommended dosage for Curcumin?

General: 500-2,000 mg/day of enhanced bioavailability form; Cognitive Support: 90-180 mg/day Theracurmin or equivalent

What are the side effects of Curcumin?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Headache, Skin rash (rare), Yellow staining of teeth with powder forms.

Curcumin is the primary bioactive compound in turmeric (Curcuma longa). It has potent anti-inflammatory and antioxidant properties and has been studied for its potential neuroprotective effects, including supporting brain-derived neurotrophic factor (BDNF) levels and reducing neuroinflammation.

What dosage of Curcumin has been used in brain health studies?

Cognitive studies have used 500 mg to 2,000 mg of curcumin daily. Bioavailability-enhanced formulations (such as those with piperine, phospholipids, or nanoparticle technology) are preferred because standard curcumin is poorly absorbed. Consult your healthcare provider for guidance.

What are the potential side effects of Curcumin?

Curcumin is generally well tolerated but may cause gastrointestinal discomfort, nausea, or diarrhea at high doses. It may interact with blood-thinning medications, diabetes drugs, and iron absorption. People with gallbladder disease should exercise caution. Consult your doctor.

Curcumin
Curcumin

antioxidant

別名: Turmeric Extract, Diferuloylmethane, Theracurmin, Longvida, CurQfen

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About

Curcumin is the primary bioactive compound in turmeric with potent anti-neuroinflammatory and neuroprotective properties. Enhanced bioavailability forms cross the blood-brain barrier and may reduce amyloid-beta aggregation. A UCLA 18-month RCT found bioavailable curcumin improved memory test performance and reduced brain amyloid/tau PET signals in non-demented adults.

How It Works

Crosses the blood-brain barrier in enhanced forms; binds to amyloid-beta plaques reducing aggregation; reduces tau phosphorylation; exhibits potent anti-neuroinflammatory effects; stimulates hippocampal neurogenesis via BDNF upregulation.

Evidence For Conditions

症状・状態	グレード	研究数	参加者数
Oxidative Stress & Neuroinflammation	B	15	1200	詳細を見る →
Age-Related Cognitive Decline	B	10	800	詳細を見る →
Memory Loss	C	8	600	詳細を見る →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Headache
Skin rash (rare)
Yellow staining of teeth with powder forms

Drug & Supplement Interactions

Anticoagulants (may increase bleeding risk)
Antidiabetic drugs (may enhance blood sugar lowering)
CYP450 substrates (may affect drug metabolism)
Iron supplements (curcumin may chelate iron)

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Related Ingredients

Lutein & Zeaxanthin Resveratrol Astaxanthin Alpha-Lipoic Acid PQQ (Pyrroloquinoline Quinone)

基本情報

用量: General: 500-2,000 mg/day of enhanced bioavailability form; Cognitive_Support: 90-180 mg/day Theracurmin or equivalent
剤形: capsule tablet powder liquid
天然の供給源: Turmeric root (Curcuma longa)
上限量: Well-tolerated up to 8,000 mg/day; 12,000 mg/day short-term
推奨摂取タイミング: With meals containing fat and black pepper (piperine) for absorption

エビデンスの要約

Oxidative Stress & Neuroinflammation B

Age-Related Cognitive Decline B

Memory Loss C

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。