Green Tea Extract (EGCG) pour Oxidative Stress & Neuroinflammation
C Preuves Preuves limitées issues de petites études, mais certains signaux positifs existent.Research suggests EGCG inhibits beta-amyloid aggregation and provides antioxidant neuroprotection. Strong epidemiological data links regular green tea consumption to reduced cognitive decline risk.
En conclusion
Research suggests EGCG inhibits beta-amyloid aggregation and provides antioxidant neuroprotection. Strong epidemiological data links regular green tea consumption to reduced cognitive decline risk.
Key Study Findings
Population: older adults and individuals with neurodegenerative disorders
Population: Children with autism spectrum disorder
Population: Alzheimer's disease (review with in silico)
Population: None
Population: Rat model
Population: Aging brain and NDD models (review)
Key Statistics
10
Études
800
Participants
Positive
Note
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- general:
- 250-500 mg/day EGCG
- viatea:
- 3-5 cups/day
Limite supérieure : 800 mg/day EGCG from supplements (hepatotoxicity risk above)
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | 5 weeks | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | 8 weeks | Positive | -- |
Moment optimal de prise : Between meals; avoid on empty stomach
Safety & Side Effects
Effets indésirables signalés
- ⚠ Liver toxicity at high doses (>800 mg EGCG/day)
- ⚠ Insomnia (caffeine content)
- ⚠ Gastrointestinal discomfort
- ⚠ Iron absorption reduction
Interactions connues
- ● Iron supplements (tannins reduce absorption)
- ● Nadolol (reduces blood levels)
- ● Blood thinners (mild antiplatelet effect)
- ● MAO inhibitors (caffeine interaction)
Apport maximal tolérable : 800 mg/day EGCG from supplements (hepatotoxicity risk above)
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does Green Tea Extract (EGCG) help with Oxidative Stress & Neuroinflammation?
How much Green Tea Extract (EGCG) should I take for Oxidative Stress & Neuroinflammation?
Are there side effects of Green Tea Extract (EGCG)?
How strong is the evidence for Green Tea Extract (EGCG) and Oxidative Stress & Neuroinflammation?
Related Evidence
Autres ingrédients pour Oxidative Stress & Neuroinflammation
References
- [1] Lei Wang et al.. Phytother Res. 2026. Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function … doi:10.1002/ptr.70198 PubMed
- [2] Rarchita Sharma et al.. Nutr Neurosci. 2025. Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection. doi:10.1080/1028415X.2025.2469170 PubMed
- [3] Guifei Chen et al.. Food Sci Nutr. 2025. Polyphenols and Alzheimer's Disease: A Review on Molecular and Therapeutic Insights With In Silico Support. doi:10.1002/fsn3.70496 PubMed
- [4] Nasser M Aldekhail et al.. Altern Ther Health Med. 2025. Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines. PubMed
- [5] Silvia Tejada et al.. Nutrients. 2024. Mitigating Age-Related Cognitive Decline and Oxidative Status in Rats Treated with Catechin and Polyphenon-60. doi:10.3390/nu16030368 PubMed
- [6] Hamid Mostafavi Abdolmaleky et al.. Nutrients. 2023. Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals. doi:10.3390/nu15153456 PubMed
- [7] Yumin Wang et al.. Front Pharmacol. 2022. Epigallocatechin-3-gallate: A phytochemical as a promising drug candidate for the treatment of Parkinson's disease. doi:10.3389/fphar.2022.977521 PubMed
- [8] Belén Mollá et al.. Mol Neurobiol. 2021. Modulators of Neuroinflammation Have a Beneficial Effect in a Lafora Disease Mouse Model. doi:10.1007/s12035-021-02285-1 PubMed
- [9] Zhipeng Kan et al.. Mol Nutr Food Res. 2021. Green Tea Suppresses Amyloid β Levels and Alleviates Cognitive Impairment by Inhibiting APP Cleavage and Preventing Neurotoxicity in 5XFAD Mice. doi:10.1002/mnfr.202100626 PubMed
- [10] Danica Michaličková et al.. Eur J Pharmacol. 2020. Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis. doi:10.1016/j.ejphar.2020.172973 PubMed
- [11] Madhuri Venigalla et al.. Neurochem Int. 2016. Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease. doi:10.1016/j.neuint.2015.10.011 PubMed
- [12] Marcos H Okuda et al.. J Nutr Biochem. 2014. Green tea extract improves high fat diet-induced hypothalamic inflammation, without affecting the serotoninergic system. doi:10.1016/j.jnutbio.2014.05.012 PubMed
- [13] Kuo-Jen Wu et al.. Evid Based Complement Alternat Med. 2012. Green Tea Extract Ameliorates Learning and Memory Deficits in Ischemic Rats via Its Active Component Polyphenol Epigallocatechin-3-gallate by Modulation of … doi:10.1155/2012/163106 PubMed
- [14] Barkha P Patel et al.. Clin Nutr. 2009. Nutritional and exercise-based interventions in the treatment of amyotrophic lateral sclerosis. doi:10.1016/j.clnu.2009.06.002 PubMed
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