N-Acetyl Cysteine pour Oxidative Stress & Neuroinflammation
B Preuves Au moins un essai randomisé le soutient, avec des résultats globalement concordants.As a glutathione precursor, NAC provides potent antioxidant and anti-inflammatory neuroprotection. Combined with selenium, research suggests synergistic protection against oxidative brain injury.
En conclusion
As a glutathione precursor, NAC provides potent antioxidant and anti-inflammatory neuroprotection. Combined with selenium, research suggests synergistic protection against oxidative brain injury.
Key Study Findings
Population: expert consensus on therapeutics for provoked vestibulodynia
Population: 3D in vitro gut-peripheral nerve axis model
Population: Preclinical neurodegenerative disease models
Population: Preclinical models
Population: Depression patients
Population: Aging brain and NDD models (review)
Key Statistics
12
Études
800
Participants
Positive
Note
Referenced Papers
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Posologies couramment utilisées
- general:
- 600-1,800 mg/day
- neuroprotection:
- 1,200-2,400 mg/day
Limite supérieure : Not established as supplement; 6,000+ mg/day used clinically (IV)
Posologies étudiées dans la recherche
| Posologie | Durée | Effet | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
Moment optimal de prise : On empty stomach; split into 2-3 doses; supplement zinc if using long-term
Safety & Side Effects
Effets indésirables signalés
- ⚠ Nausea and vomiting
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/smell
- ⚠ Rare: bronchospasm (inhaled form)
- ⚠ Long-term use may deplete zinc stores
Interactions connues
- ● Nitroglycerin (may enhance hypotensive effects)
- ● Activated charcoal (reduces NAC absorption)
- ● Anticoagulants (theoretical interaction)
Apport maximal tolérable : Not established as supplement; 6,000+ mg/day used clinically (IV)
Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
Frequently Asked Questions
Does N-Acetyl Cysteine help with Oxidative Stress & Neuroinflammation?
How much N-Acetyl Cysteine should I take for Oxidative Stress & Neuroinflammation?
Are there side effects of N-Acetyl Cysteine?
How strong is the evidence for N-Acetyl Cysteine and Oxidative Stress & Neuroinflammation?
Related Evidence
Autres ingrédients pour Oxidative Stress & Neuroinflammation
N-Acetyl Cysteine pour d'autres pathologies
References
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- [2] Pin Gong et al.. Mol Nutr Food Res. 2025. Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications. doi:10.1002/mnfr.70080 PubMed
- [3] Simone Mulè et al.. Brain Sci. 2025. Neuroinflammation-Modulating Properties Combining Glutathione, N-Acetylcysteine, and Uridine Monophosphate in a Formulation Supplement: An In Vitro Study. doi:10.3390/brainsci15121340 PubMed
- [4] Alexander Shtilbans. J Nutr. 2025. Combination Supplement Therapy: A New Frontier in Treatment of Neurodegenerative Diseases. doi:10.1016/j.tjnut.2025.07.004 PubMed
- [5] Yuyan Chen et al.. Ecotoxicol Environ Saf. 2024. Noise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment. doi:10.1016/j.ecoenv.2024.117411 PubMed
- [6] Hamid Mostafavi Abdolmaleky et al.. Nutrients. 2023. Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals. doi:10.3390/nu15153456 PubMed
- [7] Jonathan Paulo Agnes et al.. J Pain. 2021. Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation. doi:10.1016/j.jpain.2021.03.142 PubMed
- [8] Mihai-Vlad Valu et al.. J Fungi (Basel). 2021. Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment. doi:10.3390/jof7060477 PubMed
- [9] Sergi Ferré et al.. Sleep Med Clin. 2021. Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. doi:10.1016/j.jsmc.2021.02.012 PubMed
- [10] Mujtaba Aamir Bhat et al.. Biomolecules. 2020. Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases. doi:10.3390/biom10060863 PubMed
- [11] Marc J Kaufman et al.. Neurosci Biobehav Rev. 2019. Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? doi:10.1016/j.neubiorev.2019.02.014 PubMed
- [12] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
- [13] Alan D Strickland. Med Hypotheses. 2014. Prevention of cerebral palsy, autism spectrum disorder, and attention deficit-hyperactivity disorder. doi:10.1016/j.mehy.2014.02.003 PubMed
- [14] Lynn Marie Trotti et al.. Handb Clin Neurol. 2011. Restless legs syndrome. doi:10.1016/B978-0-444-52014-2.00047-1 PubMed
- [15] Birgit M Dietz et al.. Brain Res Mol Brain Res. 2005. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. doi:10.1016/j.molbrainres.2005.04.009 PubMed
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