N-Acetyl Cysteine untuk Oxidative Stress & Neuroinflammation
B Bukti Setidaknya satu uji coba acak mendukung hal ini, dengan hasil yang sebagian besar konsisten.As a glutathione precursor, NAC provides potent antioxidant and anti-inflammatory neuroprotection. Combined with selenium, research suggests synergistic protection against oxidative brain injury.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'braincited.com';
const params = 'ingredient\u003Dn\u002Dacetyl\u002Dcysteine\u0026condition\u003Doxidative\u002Dneuroinflammation';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
B
Kesimpulan
As a glutathione precursor, NAC provides potent antioxidant and anti-inflammatory neuroprotection. Combined with selenium, research suggests synergistic protection against oxidative brain injury.
Key Study Findings
Other
Executive Summary of the Vulvodynia Therapeutic Research Summit.
Dose: None
vs: None
Outcome: None
Efek: None
None
Populasi: expert consensus on therapeutics for provoked vestibulodynia
In Vitro
Neuroinflammation-Modulating Properties Combining Glutathione, N-Acetylcysteine, and Uridine Monophosphate in a Formulation Supplement: An In Vitro …
Dose: None
vs: ALA-based formula (SUPERALA CARNITINE)
Outcome: Neuroprotective and anti-inflammatory effects
Efek: None
None
Populasi: 3D in vitro gut-peripheral nerve axis model
Review
Combination Supplement Therapy: A New Frontier in Treatment of Neurodegenerative Diseases.
Dose: None
vs: None
Outcome: Neurodegenerative disease pathology attenuation
Efek: None
None
Populasi: Preclinical neurodegenerative disease models
Systematic Review
Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications.
Dose: None
vs: None
Outcome: Antidepressant effects (neurotransmitter modulation)
Efek: None
None
Populasi: Preclinical models
Review
Noise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment.
Dose: None
vs: None
Outcome: Inflammatory markers
Efek: None
None
Populasi: Depression patients
Review
Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic …
Dose: Various phytochemicals
vs: None
Outcome: Neuroprotection in aging and neurodegeneration
Efek: None
None
Populasi: Aging brain and NDD models (review)
Key Statistics
12
Studi
800
Peserta
↑
Positive
B
Peringkat
Referenced Papers
Obstetrics and gynecology
2026
Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications.
Systematic Review
Molecular nutrition & …
2025
8 sitasi
Brain sciences
2025
The Journal of …
2025
Ecotoxicology and environmental …
2024
7 sitasi
Nutrients
2023
31 sitasi
The journal of …
2021
41 sitasi
Journal of fungi …
2021
14 sitasi
Sleep medicine clinics
2021
14 sitasi
Biomolecules
2020
28 sitasi
Neuroscience and biobehavioral …
2019
45 sitasi
N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging.
Other
Canadian journal of …
2018
37 sitasi
Medical hypotheses
2014
36 sitasi
Restless legs syndrome.
Review
Handbook of clinical …
2011
8 sitasi
Brain research. Molecular …
2005
160 sitasi
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosis yang Umum Digunakan
- general:
- 600-1,800 mg/day
- neuroprotection:
- 1,200-2,400 mg/day
Batas atas: Not established as supplement; 6,000+ mg/day used clinically (IV)
Dosis yang Diteliti dalam Penelitian
| Dosis | Durasi | Efek | N |
|---|---|---|---|
| None | -- | Neutral | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| Various phytochemicals | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
Waktu terbaik diminum: On empty stomach; split into 2-3 doses; supplement zinc if using long-term
Safety & Side Effects
Efek Samping yang Dilaporkan
- ⚠ Nausea and vomiting
- ⚠ Diarrhea
- ⚠ Unpleasant sulfur taste/smell
- ⚠ Rare: bronchospasm (inhaled form)
- ⚠ Long-term use may deplete zinc stores
Interaksi yang Diketahui
- ● Nitroglycerin (may enhance hypotensive effects)
- ● Activated charcoal (reduces NAC absorption)
- ● Anticoagulants (theoretical interaction)
Asupan atas yang dapat ditoleransi: Not established as supplement; 6,000+ mg/day used clinically (IV)
Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.
Frequently Asked Questions
Does N-Acetyl Cysteine help with Oxidative Stress & Neuroinflammation?
Based on 12 studies with 800 participants, there is moderate evidence from clinical studies that N-Acetyl Cysteine may support Oxidative Stress & Neuroinflammation management. Our evidence grade is B (Good Evidence).
How much N-Acetyl Cysteine should I take for Oxidative Stress & Neuroinflammation?
Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of N-Acetyl Cysteine?
Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for N-Acetyl Cysteine and Oxidative Stress & Neuroinflammation?
We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 800 total participants. The overall direction of effect is positive.
Related Evidence
Bahan lain untuk Oxidative Stress & Neuroinflammation
N-Acetyl Cysteine untuk kondisi lain
References
- [1] Jill M Krapf et al.. Obstet Gynecol. 2026. Executive Summary of the Vulvodynia Therapeutic Research Summit. doi:10.1097/AOG.0000000000006118 PubMed
- [2] Pin Gong et al.. Mol Nutr Food Res. 2025. Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications. doi:10.1002/mnfr.70080 PubMed
- [3] Simone Mulè et al.. Brain Sci. 2025. Neuroinflammation-Modulating Properties Combining Glutathione, N-Acetylcysteine, and Uridine Monophosphate in a Formulation Supplement: An In Vitro Study. doi:10.3390/brainsci15121340 PubMed
- [4] Alexander Shtilbans. J Nutr. 2025. Combination Supplement Therapy: A New Frontier in Treatment of Neurodegenerative Diseases. doi:10.1016/j.tjnut.2025.07.004 PubMed
- [5] Yuyan Chen et al.. Ecotoxicol Environ Saf. 2024. Noise exposure-induced the cerebral alterations: From emerging evidence to antioxidant-mediated prevention and treatment. doi:10.1016/j.ecoenv.2024.117411 PubMed
- [6] Hamid Mostafavi Abdolmaleky et al.. Nutrients. 2023. Underlying Mechanisms of Brain Aging and Neurodegenerative Diseases as Potential Targets for Preventive or Therapeutic Strategies Using Phytochemicals. doi:10.3390/nu15153456 PubMed
- [7] Jonathan Paulo Agnes et al.. J Pain. 2021. Antioxidants Improve Oxaliplatin-Induced Peripheral Neuropathy in Tumor-Bearing Mice Model: Role of Spinal Cord Oxidative Stress and Inflammation. doi:10.1016/j.jpain.2021.03.142 PubMed
- [8] Mihai-Vlad Valu et al.. J Fungi (Basel). 2021. Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment. doi:10.3390/jof7060477 PubMed
- [9] Sergi Ferré et al.. Sleep Med Clin. 2021. Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. doi:10.1016/j.jsmc.2021.02.012 PubMed
- [10] Mujtaba Aamir Bhat et al.. Biomolecules. 2020. Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases. doi:10.3390/biom10060863 PubMed
- [11] Marc J Kaufman et al.. Neurosci Biobehav Rev. 2019. Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? doi:10.1016/j.neubiorev.2019.02.014 PubMed
- [12] Geetika Garg et al.. Can J Physiol Pharmacol. 2018. N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. doi:10.1139/cjpp-2018-0209 PubMed
- [13] Alan D Strickland. Med Hypotheses. 2014. Prevention of cerebral palsy, autism spectrum disorder, and attention deficit-hyperactivity disorder. doi:10.1016/j.mehy.2014.02.003 PubMed
- [14] Lynn Marie Trotti et al.. Handb Clin Neurol. 2011. Restless legs syndrome. doi:10.1016/B978-0-444-52014-2.00047-1 PubMed
- [15] Birgit M Dietz et al.. Brain Res Mol Brain Res. 2005. Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. doi:10.1016/j.molbrainres.2005.04.009 PubMed
Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.