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PQQ (Pyrroloquinoline Quinone) pour Age-Related Cognitive Decline

C

A double-blind RCT of 64 subjects found 21.5 mg/day PQQ improved memory, attention, and cognitive function after 12 weeks. A separate trial in MCI patients showed cerebral oxygenation increased from 48.4% to 52.8%.

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En conclusion

            
            
A double-blind RCT of 64 subjects found 21.5 mg/day PQQ improved memory, attention, and cognitive function after 12 weeks. A separate trial in MCI patients showed cerebral oxygenation increased from 48.4% to 52.8%.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                6 weeks
                
                
                Double-blind
                
            

            
                The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in …
            
            

                
                Dose: None
                
                
                vs: Placebo
                
                
                Outcome: Cognitive function
                
                
                Effet: None
                
                
                P = 0.01
                
            

            
            
Population: Alzheimer's disease patients

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
4

        
Études

    

    

        
200

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Note

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive …
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The journal of …
                        2024
                        
                        6 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Posologies couramment utilisées

                

                    
                    

                        
general:

                        
10-20 mg/day

                    

                    
                    

                        
cognitivesupport:

                        
20 mg/day

                    

                    
                

                
                

                    Limite supérieure : Not established; well-tolerated up to 60 mg/day
                

                
            

            

            
            

                
Posologies étudiées dans la recherche

                

                    

                        
                            

                                Posologie
                                Durée
                                Effet
                                N
                            

                        
                        
                            
                            

                                None
                                6 weeks
                                
                                    
                                    Neutral
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Moment optimal de prise : With meals
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effets indésirables signalés

                    
    
                        
                        
  • 
                            ⚠
                            Headache
                        
    • 
                        
                        
  • 
                            ⚠
                            Insomnia
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild fatigue
                        
    • 
                        
                    

                

                

                
                

                    
Interactions connues

                    
    
                        
                        
  • 
                            ●
                            No significant drug interactions established
                        
    • 
                        
                    

                

                

                
                

                    

                        Apport maximal tolérable : Not established; well-tolerated up to 60 mg/day
                    

                

                
            

            

                Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does PQQ (Pyrroloquinoline Quinone) help with Age-Related Cognitive Decline?
            
        
        

            Based on 4 studies with 200 participants, there is limited but promising evidence that PQQ (Pyrroloquinoline Quinone) may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much PQQ (Pyrroloquinoline Quinone) should I take for Age-Related Cognitive Decline?
            
        
        

            Studies have used various dosages. A commonly studied range is 10-20 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of PQQ (Pyrroloquinoline Quinone)?
            
        
        

            Reported side effects may include Headache, Insomnia, Mild fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for PQQ (Pyrroloquinoline Quinone) and Age-Related Cognitive Decline?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
            

        

        

    


    
    












    

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