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Molecular analysis of SIRT1 expression and activity levels in vascular tissue from MTHFR-deficient subjects. The data reveal that MTHFR deficiency is associated with altered SIRT1 signaling, which may contribute to cardiovascular risk.
Figure 4
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SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency.Cite This Figure
![Figure 4: Molecular analysis of SIRT1 expression and activity levels in vascular tissue from MTHFR-deficient subjects. The data reveal that MTHFR deficiency is associated with altered SIRT1 signaling, which may contribute to cardiovascular risk.]() > Source: Albino Carrizzo et al. "SIRT1 pharmacological activation rescues vascular dysfunction and prevents throm." *Cellular and molecular life sciences : CMLS*, 2022. PMID: [35821533](https://pubmed.ncbi.nlm.nih.gov/35821533/)
<figure> <img src="" alt="Molecular analysis of SIRT1 expression and activity levels in vascular tissue from MTHFR-deficient subjects. The data reveal that MTHFR deficiency is associated with altered SIRT1 signaling, which may contribute to cardiovascular risk." /> <figcaption>Figure 4. Molecular analysis of SIRT1 expression and activity levels in vascular tissue from MTHFR-deficient subjects. The data reveal that MTHFR deficiency is associated with altered SIRT1 signaling, which may contribute to cardiovascular risk.<br> Source: Albino Carrizzo et al. "SIRT1 pharmacological activation rescues vascular dysfunction and prevents throm." <em>Cellular and molecular life sciences : CMLS</em>, 2022. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/35821533/">35821533</a></figcaption> </figure>