Folate untuk Nutritional Deficiency Cognitive Impairment

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

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Kesimpulan

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

Key Study Findings

Observational Study n=2582

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …

Dose: None vs: None Outcome: Cognitive impairment risk Efek: OR=0.695 (Vit D); OR=0.777 (FA) p=0.003 (Vit D); p=0.034 (FA)

Populasi: Elderly participants aged 60+ from NHANES 2011-2014

Cross-Sectional Study n=1966

Folate mediates cognitive impairment of aged people with periodontitis.

Dose: None vs: Placebo Efek: Mediation proportion: dietary supplement folate 8.4%; serum total folate 9.1%; RBC folate 9.1% None

Review

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.

Dose: None vs: None Outcome: Pregnancy outcomes and offspring neurodevelopment Efek: None None

Populasi: Pregnant women (review)

Meta-Analysis

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.

Dose: None vs: Standard care or placebo Outcome: Global cognition in stroke survivors Efek: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Populasi: Adult stroke survivors (20 trials + 14 observational)

Other

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.

Dose: None vs: None Outcome: Causal association of micronutrients with RLS Efek: Retinol OR 0.46; Mg OR 0.62 None

Populasi: European ancestry (7248 RLS cases, 19802 controls)

Randomized Controlled Trial Double-blind

Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.

Dose: Vitamin B12 (measured, not supplemented) vs: Within-trial comparison Outcome: B12/homocysteine association with PD outcomes Efek: None None

Populasi: Early Parkinson's disease patients

Key Statistics

Studi

1500

Peserta

↑

Positive

Peringkat

Referenced Papers

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. Other

Brain and behavior 2026

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. Review

The Proceedings of … 2025 5 sitasi

Folate mediates cognitive impairment of aged people with periodontitis. Other

Nutritional neuroscience 2025 1 sitasi

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. Meta-Analysis

Advances in nutrition … 2025 1 sitasi

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. Other

Food science & … 2025

Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications? Review

Food and nutrition … 2024 19 sitasi

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … Meta-Analysis

European journal of … 2024 16 sitasi

Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials. RCT

Journal of Parkinson's … 2024 1 sitasi

The Role of One-Carbon Metabolism in Healthy Brain Aging. Review

Nutrients 2023 9 sitasi

Dietary folate intake and its association with longitudinal changes in cognition function. Other

Clinical nutrition ESPEN 2023 5 sitasi

Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … Other

The British journal … 2022 7 sitasi

Decreasing the Symptoms of Essential Tremor With Medical Painting Therapy. Case Report

The Permanente journal 2022

Impact of a Nordic diet on psychological function in young students. Other

Nutrition and health 2021 13 sitasi

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 sitasi

Vitamin B-Can it prevent cognitive decline? A systematic review and meta-analysis. Meta-Analysis

Systematic reviews 2020 29 sitasi

Homocysteine and Dementia: An International Consensus Statement. Other

Journal of Alzheimer's … 2018 281 sitasi

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. Meta-Analysis

The Cochrane database … 2018 123 sitasi

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. Review

The journal of … 2017 75 sitasi

Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Review

Nutrients 2016 114 sitasi

Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. Review

The journal of … 2015 25 sitasi

[Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. Review

Ginekologia polska 2015 7 sitasi

Vitamin B12 and cognitive function: an evidence-based analysis. Review

Ontario health technology … 2013

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 sitasi

Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Systematic Review

Archives of internal … 2007 222 sitasi

Multivitamin/mineral supplements and prevention of chronic disease. Review

Evidence report/technology assessment 2006

Folic acid with or without vitamin B12 for cognition and dementia. Systematic Review

The Cochrane database … 2003 263 sitasi

Nutrients, age and cognitive function. Review

Current opinion in … 1998 30 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 400 mcg DFE/day (RDA)
cognitivesupport:: 400-800 mcg/day

Batas atas: 1,000 mcg/day from supplements (may mask B12 deficiency)

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	2582
None	--	Positive	1966
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
Vitamin B12 (measured, not supplemented)	--	Positive	--
None	--	Positive	--
>5 mg/day	--	Negative	--

Waktu terbaik diminum: With or without food; morning preferred

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Generally well-tolerated
⚠ May mask B12 deficiency symptoms
⚠ Rare: insomnia or irritability at high doses

Interaksi yang Diketahui

● Methotrexate (antagonist — folate reduces efficacy)
● Anticonvulsants (phenytoin, carbamazepine — mutual interference)
● Sulfasalazine (reduces folate absorption)

Asupan atas yang dapat ditoleransi: 1,000 mcg/day from supplements (may mask B12 deficiency)

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Folate help with Nutritional Deficiency Cognitive Impairment?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Folate may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).

How much Folate should I take for Nutritional Deficiency Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Folate?

Reported side effects may include Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Folate and Nutritional Deficiency Cognitive Impairment?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Nutritional Deficiency Cognitive Impairment

Vitamin B12 A Vitamin D B

Kesimpulan Singkat

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

Evidence Strength72%

High confidence

Rincian Studi

RCT (1)Meta (4)Other (5)

Bandingkan Alternatif

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Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.