N-Acetyl Cysteine untuk Post-Concussion Cognitive Symptoms

NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.

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Kesimpulan

NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.

Key Study Findings

Randomized Controlled Trial n=50 Open-label

Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With …

Dose: None vs: waitlist control (standard of care) Outcome: resting-state functional connectivity and cognitive-affective symptoms Efek: None p<0.05

Populasi: patients with chronic post-concussion syndrome for at least 3 months

Review

Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols.

Dose: None vs: None Outcome: TBI prevention and neuroprotection Efek: None None

Populasi: Individuals with or at risk for TBI

Controlled Clinical Trial n=65 4 weeks Open-label

N -acetylcysteine is associated with reduction of postconcussive symptoms in elderly patients: A pilot study.

Dose: None vs: Standard care alone Outcome: RPQ postconcussion symptom severity Efek: RPQ day 7: 2 vs 10; day 30: 0 vs 4 p=0.004 (day 7); p=0.021 (day

Populasi: Elderly patients (>=60y) with mild TBI

Review

Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox.

Dose: None vs: None Outcome: None Efek: None None

Populasi: restless legs syndrome

Review

Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia?

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

Review

Dietary Supplements for Health, Adaptation, and Recovery in Athletes.

Dose: None vs: None Outcome: Health, adaptation, and recovery in athletes Efek: None None

Populasi: Athletes

Key Statistics

Studi

400

Peserta

↑

Positive

Peringkat

Referenced Papers

Changes in Resting-State Functional Connectivity and Cognitive-Affective Symptoms in Patients With Post-Concussion Syndrome Treated With N-Acetyl Cysteine. RCT

The Journal of … None

Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols. Review

Nutrients 2024 22 sitasi

N -acetylcysteine is associated with reduction of postconcussive symptoms in elderly patients: A pilot study. Other

The journal of … 2022 7 sitasi

Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox. Review

Sleep medicine clinics 2021 14 sitasi

Supraphysiologic-dose anabolic-androgenic steroid use: A risk factor for dementia? Review

Neuroscience and biobehavioral … 2019 45 sitasi

Dietary Supplements for Health, Adaptation, and Recovery in Athletes. Review

International journal of … 2018 165 sitasi

N-acetyl-l-cysteine attenuates oxidative damage and neurodegeneration in rat brain during aging. Other

Canadian journal of … 2018 37 sitasi

Restless legs syndrome. Review

Handbook of clinical … 2011 8 sitasi

Valerian extract and valerenic acid are partial agonists of the 5-HT5a receptor in vitro. Other

Brain research. Molecular … 2005 160 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 600-1,800 mg/day
neuroprotection:: 1,200-2,400 mg/day

Batas atas: Not established as supplement; 6,000+ mg/day used clinically (IV)

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	50
None	--	Positive	--
None	4 weeks	Positive	65
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
NAC 100 mg/kg body weight orally daily for 14 days	2 weeks	Positive	24
None	--	Mixed	--

Waktu terbaik diminum: On empty stomach; split into 2-3 doses; supplement zinc if using long-term

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Nausea and vomiting
⚠ Diarrhea
⚠ Unpleasant sulfur taste/smell
⚠ Rare: bronchospasm (inhaled form)
⚠ Long-term use may deplete zinc stores

Interaksi yang Diketahui

● Nitroglycerin (may enhance hypotensive effects)
● Activated charcoal (reduces NAC absorption)
● Anticoagulants (theoretical interaction)

Asupan atas yang dapat ditoleransi: Not established as supplement; 6,000+ mg/day used clinically (IV)

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does N-Acetyl Cysteine help with Post-Concussion Cognitive Symptoms?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that N-Acetyl Cysteine may support Post-Concussion Cognitive Symptoms management. Our evidence grade is B (Good Evidence).

How much N-Acetyl Cysteine should I take for Post-Concussion Cognitive Symptoms?

Studies have used various dosages. A commonly studied range is 600-1,800 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of N-Acetyl Cysteine?

Reported side effects may include Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for N-Acetyl Cysteine and Post-Concussion Cognitive Symptoms?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

N-Acetyl Cysteine untuk kondisi lain

Oxidative Stress & Neuroinflammation B Depression-Related Cognitive Dysfunction C

Kesimpulan Singkat

NAC demonstrated neuroprotective effects in traumatic brain injury models. MRI studies showed improvements in resting-state brain connectivity in mild TBI patients receiving NAC treatment.

Evidence Strength72%

High confidence

Rincian Studi

RCT (1)Meta (0)Other (5)

Bandingkan Alternatif

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Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.