Folate per Nutritional Deficiency Cognitive Impairment

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

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In sintesi

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

Key Study Findings

Observational Study n=2582

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …

Dose: None vs: None Outcome: Cognitive impairment risk Effetto: OR=0.695 (Vit D); OR=0.777 (FA) p=0.003 (Vit D); p=0.034 (FA)

Popolazione: Elderly participants aged 60+ from NHANES 2011-2014

Cross-Sectional Study n=1966

Folate mediates cognitive impairment of aged people with periodontitis.

Dose: None vs: Placebo Effetto: Mediation proportion: dietary supplement folate 8.4%; serum total folate 9.1%; RBC folate 9.1% None

Review

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.

Dose: None vs: None Outcome: Pregnancy outcomes and offspring neurodevelopment Effetto: None None

Popolazione: Pregnant women (review)

Meta-Analysis

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.

Dose: None vs: Standard care or placebo Outcome: Global cognition in stroke survivors Effetto: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Popolazione: Adult stroke survivors (20 trials + 14 observational)

Other

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.

Dose: None vs: None Outcome: Causal association of micronutrients with RLS Effetto: Retinol OR 0.46; Mg OR 0.62 None

Popolazione: European ancestry (7248 RLS cases, 19802 controls)

Randomized Controlled Trial Double-blind

Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.

Dose: Vitamin B12 (measured, not supplemented) vs: Within-trial comparison Outcome: B12/homocysteine association with PD outcomes Effetto: None None

Popolazione: Early Parkinson's disease patients

Key Statistics

Studi

1500

Partecipanti

↑

Positive

Grado

Referenced Papers

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. Other

Brain and behavior 2026

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. Review

The Proceedings of … 2025 5 citazioni

Folate mediates cognitive impairment of aged people with periodontitis. Other

Nutritional neuroscience 2025 1 citazioni

Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis. Meta-Analysis

Advances in nutrition … 2025 1 citazioni

Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk. Other

Food science & … 2025

Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications? Review

Food and nutrition … 2024 19 citazioni

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … Meta-Analysis

European journal of … 2024 16 citazioni

Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials. RCT

Journal of Parkinson's … 2024 1 citazioni

The Role of One-Carbon Metabolism in Healthy Brain Aging. Review

Nutrients 2023 9 citazioni

Dietary folate intake and its association with longitudinal changes in cognition function. Other

Clinical nutrition ESPEN 2023 5 citazioni

Maternal folic acid supplement use/dietary folate intake from preconception to early pregnancy and neurodevelopment in 2-year-old offspring: the Japan Environment … Other

The British journal … 2022 7 citazioni

Decreasing the Symptoms of Essential Tremor With Medical Painting Therapy. Case Report

The Permanente journal 2022

Impact of a Nordic diet on psychological function in young students. Other

Nutrition and health 2021 13 citazioni

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 citazioni

Vitamin B-Can it prevent cognitive decline? A systematic review and meta-analysis. Meta-Analysis

Systematic reviews 2020 29 citazioni

Homocysteine and Dementia: An International Consensus Statement. Other

Journal of Alzheimer's … 2018 281 citazioni

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. Meta-Analysis

The Cochrane database … 2018 123 citazioni

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. Review

The journal of … 2017 75 citazioni

Causes, Consequences and Public Health Implications of Low B-Vitamin Status in Ageing. Review

Nutrients 2016 114 citazioni

Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. Review

The journal of … 2015 25 citazioni

[Folate metabolism--epigenetic role of choline and vitamin B12 during pregnancy]. Review

Ginekologia polska 2015 7 citazioni

Vitamin B12 and cognitive function: an evidence-based analysis. Review

Ontario health technology … 2013

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 citazioni

Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials. Systematic Review

Archives of internal … 2007 222 citazioni

Multivitamin/mineral supplements and prevention of chronic disease. Review

Evidence report/technology assessment 2006

Folic acid with or without vitamin B12 for cognition and dementia. Systematic Review

The Cochrane database … 2003 263 citazioni

Nutrients, age and cognitive function. Review

Current opinion in … 1998 30 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 400 mcg DFE/day (RDA)
cognitivesupport:: 400-800 mcg/day

Limite massimo: 1,000 mcg/day from supplements (may mask B12 deficiency)

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Positive	2582
None	--	Positive	1966
None	--	Positive	--
None	--	Mixed	--
None	--	Mixed	--
Vitamin B12 (measured, not supplemented)	--	Positive	--
None	--	Positive	--
>5 mg/day	--	Negative	--

Momento migliore per l'assunzione: With or without food; morning preferred

Safety & Side Effects

Effetti collaterali segnalati

⚠ Generally well-tolerated
⚠ May mask B12 deficiency symptoms
⚠ Rare: insomnia or irritability at high doses

Interazioni note

● Methotrexate (antagonist — folate reduces efficacy)
● Anticonvulsants (phenytoin, carbamazepine — mutual interference)
● Sulfasalazine (reduces folate absorption)

Livello di assunzione massimo tollerabile: 1,000 mcg/day from supplements (may mask B12 deficiency)

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Folate help with Nutritional Deficiency Cognitive Impairment?

Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Folate may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).

How much Folate should I take for Nutritional Deficiency Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 400 mcg DFE/day (RDA). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Folate?

Reported side effects may include Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Folate and Nutritional Deficiency Cognitive Impairment?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Nutritional Deficiency Cognitive Impairment

Vitamin B12 A Vitamin D B

Verdetto rapido

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

Evidence Strength72%

High confidence

Analisi degli studi

RCT (1)Meta (4)Other (5)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Nutritional Deficiency Cognitive Impairment

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.