Phosphatidylserine per Age-Related Cognitive Decline

The FDA has granted a qualified health claim stating phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly. Research suggests modest improvements in memory, learning, and mood in older adults.

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In sintesi

Key Study Findings

Other

Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation.

Dose: None vs: None Outcome: astrocytic lipophagy and cognitive function Effetto: None None

Popolazione: cerebral FURIN-deficient mice

Other 4 weeks

Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell …

Dose: 50, 100, or 200 mg/kg/day vs: phosphatidylserine 50 mg/kg/day (positive control) Outcome: cognitive performance in scopolamine-induced memory impairment Effetto: None None

Popolazione: male Sprague-Dawley rats with scopolamine-induced memory impairment

In Vitro

Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry.

Dose: None vs: None Outcome: Age-dependent brain lipid changes Effetto: None None

Popolazione: Mice: adult (3-4mo), middle-aged (10mo), old (19-21mo)

Review

Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.

Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d vs: None Outcome: Cognitive decline in AD Effetto: None None

Popolazione: Alzheimer's disease patients

Other

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine …

Dose: 50 mg/kg lycopene in mice vs: HFD control mice Outcome: Cognitive function (Y-maze, MWM, novel object recognition) Effetto: None None

Popolazione: HFD-induced obese male C57BL/6 mice

Other

Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline.

Dose: None vs: None Outcome: Cognitive function Effetto: None None

Popolazione: Mouse model

Key Statistics

Studi

1100

Partecipanti

↑

Positive

Grado

Referenced Papers

Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation. Other

Autophagy 2026 1 citazioni

Neuroprotective Effect of the Combined Extract of Mentha piperita and Cornus officinalis Against Neuronal Cell Death and Scopolamine-Induced Memory Impairment. Other

International journal of … 2026

Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease. Review

Nutrients 2025 9 citazioni

Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry. Other

Journal of proteome … 2025 8 citazioni

Functional food lycopene mitigates obesity-related cognitive decline via lipid metabolism regulation and neuroprotection via taurine and glutathione pathway. Other

Clinical nutrition (Edinburgh, … 2025 1 citazioni

Inhibition of miR-4763-3p expression activates the PI3K/mTOR/Bcl2 autophagy signaling pathway to ameliorate cognitive decline. Other

International journal of … 2024 6 citazioni

A mixture of extracts from natural ingredients reduces the neurotoxic polarization of microglia via modulating NF-κB/NF-E2-related factor 2 activation. Other

Food science & … 2024 3 citazioni

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 citazioni

Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat … Other

Lipids in health … 2020

Lipid Metabolism in Late-Onset Alzheimer's Disease Differs from Patients Presenting with Other Dementia Phenotypes. Other

International journal of … 2019 12 citazioni

Combining a high DHA multi-nutrient supplement with aerobic exercise: Protocol for a randomised controlled study assessing mobility and cognitive function … Other

Prostaglandins, leukotrienes, and … 2019 5 citazioni

Commentary on Some Recent Theses Relevant to Combating Aging: October 2019. Other

Rejuvenation research 2019

Effect of Age and Dietary Intervention on Discrimination Learning in Pet Dogs. Other

Frontiers in psychology 2018 13 citazioni

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … RCT

Nutrients 2016 53 citazioni

Phosphatidylserine and the human brain. Review

Nutrition (Burbank, Los … 2015 149 citazioni

Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease. Other

PloS one 2015 11 citazioni

Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. Other

Molecular medicine (Cambridge, … 2011 356 citazioni

Treatment of memory loss with herbal remedies. Other

Current treatment options … 2011 6 citazioni

Effects of long-term fish oil-enriched diet on the sphingolipid metabolism in brain of old rats. Other

Experimental gerontology 2010 33 citazioni

Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain … Other

Nutrition research (New … 2009 65 citazioni

Apoptosis in CADASIL: an in vitro study of lymphocytes and fibroblasts from a cohort of Italian patients. Other

Journal of cellular … 2009 31 citazioni

Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. Other

The Canadian veterinary … 2008

Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Review

Alternative medicine review … 2008

Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Review

Alternative medicine review … 2007

Effects of phosphatidylserine supplementation on exercising humans. Review

Sports medicine (Auckland, … 2006 42 citazioni

Safety of soy-derived phosphatidylserine in elderly people. CCT

Nutritional neuroscience 2002 46 citazioni

The influence of soy-derived phosphatidylserine on cognition in age-associated memory impairment. CCT

Nutritional neuroscience 2001 66 citazioni

A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Review

Alternative medicine review … 1999 112 citazioni

Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. RCT

Aging (Milan, Italy) 1993 137 citazioni

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosaggi di uso comune

general:: 100 mg/day
cognitivesupport:: 100-300 mg/day

Limite massimo: Well-tolerated up to 600 mg/day

Dosaggi studiati nella ricerca

Dosaggio	Durata	Effetto	N
None	--	Negative	--
50, 100, or 200 mg/kg/day	4 weeks	Positive	--
None	--	Mixed	--
Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d	--	Mixed	--
50 mg/kg lycopene in mice	--	Positive	--
None	--	Positive	--
1 μg/mL	--	Positive	--
None	72 weeks	Positive	--

Momento migliore per l'assunzione: With meals for better absorption

Safety & Side Effects

Effetti collaterali segnalati

⚠ Mild gastrointestinal discomfort
⚠ Insomnia at high doses
⚠ Rare allergic reactions (soy-derived forms)

Interazioni note

● Anticholinergic medications (may reduce PS effectiveness)
● Blood thinners (theoretical interaction)
● Cholinesterase inhibitors (additive cholinergic effects)

Livello di assunzione massimo tollerabile: Well-tolerated up to 600 mg/day

Consultare sempre il proprio medico prima di iniziare qualsiasi integratore.Consultate sempre il vostro medico prima di iniziare qualsiasi integratore.

Frequently Asked Questions

Does Phosphatidylserine help with Age-Related Cognitive Decline?

Based on 16 studies with 1,100 participants, there is moderate evidence from clinical studies that Phosphatidylserine may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).

How much Phosphatidylserine should I take for Age-Related Cognitive Decline?

Studies have used various dosages. A commonly studied range is 100 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Phosphatidylserine?

Reported side effects may include Mild gastrointestinal discomfort, Insomnia at high doses, Rare allergic reactions (soy-derived forms). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Phosphatidylserine and Age-Related Cognitive Decline?

We rate the evidence as Grade B (Good Evidence). This rating is based on 16 peer-reviewed studies with 1,100 total participants. The overall direction of effect is positive.

Related Evidence

Altri ingredienti per Age-Related Cognitive Decline

Omega-3 Fatty Acids (DHA/EPA) A Bacopa monnieri B Vitamin B12 B Curcumin B Ginkgo biloba C Panax Ginseng C

Phosphatidylserine per altre condizioni

Stress-Induced Cognitive Decline C Attention & Focus Difficulties C

Verdetto rapido

Evidence Strength72%

High confidence

Analisi degli studi

RCT (2)Meta (0)Other (14)

Confronta le alternative

Scoprite come si confrontano altri ingredienti per questa condizione.

Visualizza tutti gli ingredienti per Age-Related Cognitive Decline

Approfondimenti

Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.