Ashwagandha ： Anxiety-Related Cognitive Impairment

Q: Does Ashwagandha help with Anxiety-Related Cognitive Impairment?

Based on 12 studies with 1,000 participants, there is moderate evidence from clinical studies that Ashwagandha may support Anxiety-Related Cognitive Impairment management. Our evidence grade is B (Good Evidence).

Q: How much Ashwagandha should I take for Anxiety-Related Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Ashwagandha?

Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Ashwagandha and Anxiety-Related Cognitive Impairment?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.

Research suggests ashwagandha's withanolides may help reduce cortisol, support GABA-mimetic activity, and improve attention and executive function in individuals experiencing anxiety-related cognitive impairment.

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結論

Key Study Findings

Review

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …

Dose: None vs: None Outcome: None 効果: None None

対象集団: narrative review of ashwagandha clinical trials and basic research (1994-present)

preclinical animal/in vitro study

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …

Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs: Placebo 効果: None None

animal_study

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in …

Dose: 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) vs: Placebo 効果: At 50 mg/kg: 34% decrease in sleep onset time (p<0.0001); 47% increase in sleep duration (p<0.0001); <0.0001

In Vitro

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of …

Dose: ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model) vs: Placebo 効果: ASH improved locomotor and cognitive deficits, serum hepatotoxicity indices, oxidative stress marker

Key Statistics

研究数

1000

参加者数

↑

Positive

グレード

Referenced Papers

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. Review

Nutrients 2026

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … Other

Journal of ethnopharmacology 2025 9 件の引用

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … Other

Preventive nutrition and … 2022 18 件の引用

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … Other

Journal of ethnopharmacology 2021 69 件の引用

Neurodegenerative diseases and Withania somnifera (L.): An update. Review

Journal of ethnopharmacology 2020 85 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 300-600 mg/day of root extract (KSM-66 or Sensoril)
cognitivesupport:: 600 mg/day

上限量： Not established; well-tolerated up to 1,250 mg/day

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL	--	Positive	--
10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)	--	Positive	--
ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)	--	Positive	--

推奨摂取タイミング： With meals; morning or evening depending on individual response

Safety & Side Effects

報告されている副作用

⚠ Drowsiness
⚠ Gastrointestinal discomfort
⚠ Rare: liver injury (with contaminated or high-dose products)
⚠ Thyroid hormone elevation (may affect thyroid medications)

既知の相互作用

● Thyroid medications (may increase thyroid hormone levels)
● Sedative medications (additive CNS depression)
● Immunosuppressants (may stimulate immune activity)
● Diabetes medications (may lower blood sugar)

耐容上限摂取量： Not established; well-tolerated up to 1,250 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Ashwagandha help with Anxiety-Related Cognitive Impairment?

Based on 12 studies with 1,000 participants, there is moderate evidence from clinical studies that Ashwagandha may support Anxiety-Related Cognitive Impairment management. Our evidence grade is B (Good Evidence).

How much Ashwagandha should I take for Anxiety-Related Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Ashwagandha?

Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Ashwagandha and Anxiety-Related Cognitive Impairment?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Anxiety-Related Cognitive Impairment

L-Theanine C

Ashwagandha 他の症状・状態について

Stress-Induced Cognitive Decline B Sleep-Related Cognitive Impairment C

総合評価

Evidence Strength72%

High confidence

研究の内訳

RCT (0)Meta (0)Other (12)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Anxiety-Related Cognitive Impairment

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。