Ashwagandha 用于 焦虑相关认知障碍
B 证据 至少一项随机试验支持这一结论，结果基本一致。Research suggests ashwagandha's withanolides may help reduce cortisol, support GABA-mimetic activity, and improve attention and executive function in individuals experiencing anxiety-related cognitive impairment.
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B
结论
Research suggests ashwagandha's withanolides may help reduce cortisol, support GABA-mimetic activity, and improve attention and executive function in individuals experiencing anxiety-related cognitive impairment.
Key Study Findings
Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: narrative review of ashwagandha clinical trials and basic research (1994-present)
preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL
vs: Placebo
效果: None
None
animal_study
Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in …
Dose: 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)
vs: Placebo
效果: At 50 mg/kg: 34% decrease in sleep onset time (p<0.0001); 47% increase in sleep duration (p<0.0001);
<0.0001
In Vitro
Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of …
Dose: ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)
vs: Placebo
效果: ASH improved locomotor and cognitive deficits, serum hepatotoxicity indices, oxidative stress marker
Key Statistics
12
研究数量
1000
受试者
↑
Positive
B
等级
Referenced Papers
Nutrients
2026
Journal of ethnopharmacology
2025
9 次引用
Preventive nutrition and …
2022
18 次引用
Journal of ethnopharmacology
2021
69 次引用
Journal of ethnopharmacology
2020
85 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 300-600 mg/day of root extract (KSM-66 or Sensoril)
- cognitivesupport:
- 600 mg/day
上限： Not established; well-tolerated up to 1,250 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL | -- | Positive | -- |
| 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) | -- | Positive | -- |
| ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model) | -- | Positive | -- |
最佳服用时间： With meals; morning or evening depending on individual response
Safety & Side Effects
已报告的副作用
- ⚠ Drowsiness
- ⚠ Gastrointestinal discomfort
- ⚠ Rare: liver injury (with contaminated or high-dose products)
- ⚠ Thyroid hormone elevation (may affect thyroid medications)
已知相互作用
- ● Thyroid medications (may increase thyroid hormone levels)
- ● Sedative medications (additive CNS depression)
- ● Immunosuppressants (may stimulate immune activity)
- ● Diabetes medications (may lower blood sugar)
可耐受最高摄入量： Not established; well-tolerated up to 1,250 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Ashwagandha help with 焦虑相关认知障碍?
Based on 12 studies with 1,000 participants, there is moderate evidence from clinical studies that Ashwagandha may support 焦虑相关认知障碍 management. Our evidence grade is B (Good Evidence).
How much Ashwagandha should I take for 焦虑相关认知障碍?
Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Ashwagandha?
Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Ashwagandha and 焦虑相关认知障碍?
We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 焦虑相关认知障碍
Ashwagandha 用于其他健康状况
References
- [1] Kaj Winther. Nutrients. 2026. The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. doi:10.3390/nu18050871 PubMed
- [2] Hyeongyeong Kim et al.. J Ethnopharmacol. 2025. Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … doi:10.1016/j.jep.2024.119224 PubMed
- [3] Sindgi Vasudeva Murthy et al.. Prev Nutr Food Sci. 2022. Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … doi:10.3746/pnf.2022.27.1.108 PubMed
- [4] Heba M A Khalil et al.. J Ethnopharmacol. 2021. Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … doi:10.1016/j.jep.2021.114141 PubMed
- [5] Nawab John Dar et al.. J Ethnopharmacol. 2020. Neurodegenerative diseases and Withania somnifera (L.): An update. doi:10.1016/j.jep.2020.112769 PubMed
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