Curcumin ： Age-Related Cognitive Decline
BA UCLA 18-month RCT found bioavailable curcumin improved memory test performance and reduced brain amyloid/tau PET signals in non-demented adults. Bioavailability of the formulation is the key factor for effectiveness.
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B
結論
A UCLA 18-month RCT found bioavailable curcumin improved memory test performance and reduced brain amyloid/tau PET signals in non-demented adults. Bioavailability of the formulation is the key factor for effectiveness.
Key Study Findings
Review
Neuropharmacology of synaptic plasticity: pathways to cognitive resilience in healthy aging.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: aging individuals with cognitive decline
Review
Relationship of Curcumin with Aging and Alzheimer and Parkinson Disease, the Most Prevalent Age-Related Neurodegenerative …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Mechanisms Linking Obesity, Insulin Resistance, and Alzheimer's Disease: Effects of Polyphenols and Omega-3 Polyunsaturated Fatty …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Review
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d
vs: None
Outcome: Cognitive decline in AD
効果: None
None
対象集団: Alzheimer's disease patients
Review
Plant-based strategies against aging: Focus on bioactive compounds from medicine-food homology plants.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Systematic Review
Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes …
Dose: None
vs: Various dementia models
Outcome: Oxidative stress, inflammation, cognitive outcomes
効果: MDA reduced 100%; cognition improved ~80%
None
対象集団: Rodent dementia models (29 studies)
Key Statistics
10
研究数
800
参加者数
↔
Mixed
B
グレード
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Curcumin and Dementia: A Systematic Review of Its Effects on Oxidative Stress and Cognitive Outcomes in Animal Models.
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Meta-Analysis
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2019
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2018
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Advances in nutrition …
2018
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Advances in nutrition …
2017
215 件の引用
Curcumin in Alzheimer's disease: Can we think to new strategies and perspectives for this molecule?
Review
Pharmacological research
2017
95 件の引用
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2017
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2016
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Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-2,000 mg/day of enhanced bioavailability form
- cognitivesupport:
- 90-180 mg/day Theracurmin or equivalent
上限量： Well-tolerated up to 8,000 mg/day; 12,000 mg/day short-term
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| 100 mg/kg each | 4 weeks | Positive | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals containing fat and black pepper (piperine) for absorption
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort (nausea, diarrhea)
- ⚠ Headache
- ⚠ Skin rash (rare)
- ⚠ Yellow staining of teeth with powder forms
既知の相互作用
- ● Anticoagulants (may increase bleeding risk)
- ● Antidiabetic drugs (may enhance blood sugar lowering)
- ● CYP450 substrates (may affect drug metabolism)
- ● Iron supplements (curcumin may chelate iron)
耐容上限摂取量： Well-tolerated up to 8,000 mg/day; 12,000 mg/day short-term
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Curcumin help with Age-Related Cognitive Decline?
Based on 10 studies with 800 participants, there is moderate evidence from clinical studies that Curcumin may support Age-Related Cognitive Decline management. Our evidence grade is B (Good Evidence).
How much Curcumin should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 500-2,000 mg/day of enhanced bioavailability form. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Curcumin?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Headache, Skin rash (rare), Yellow staining of teeth with powder forms. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Curcumin and Age-Related Cognitive Decline?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 800 total participants. The overall direction of effect is mixed.
Related Evidence
に関する他の成分： Age-Related Cognitive Decline
Curcumin 他の症状・状態について
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