Lion's Mane Mushroom ： Brain Fog
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Research suggests NGF stimulation from Lion's Mane compounds may help support mental clarity. Clinical evidence is limited but growing, with anecdotal reports of reduced subjective brain fog symptoms.
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C
結論
Research suggests NGF stimulation from Lion's Mane compounds may help support mental clarity. Clinical evidence is limited but growing, with anecdotal reports of reduced subjective brain fog symptoms.
Key Study Findings
Systematic Review
Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications.
Dose: None
vs: None
Outcome: Antidepressant effects (neurotransmitter modulation)
効果: None
None
対象集団: Preclinical models
In Vitro
In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and …
Dose: None
vs: H2O2-induced oxidative stress
Outcome: Neuroprotection and cognitive decline biomarkers
効果: BDNF ~2.3-fold, NGF ~1.9-fold vs H2O2
None
対象集団: 3D intestinal model and neuronal/astrocytic co-culture
Review
Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant …
Dose: None
vs: None
Outcome: Schizophrenia symptom improvement (theoretical)
効果: None
None
対象集団: Patients with chronic/treatment-resistant schizophrenia
Review
ALSUntangled #73: Lion's Mane.
Dose: Hericium erinaceus (Lion's Mane)
vs: None
Outcome: Neuroprotection and ALS progression
効果: None
None
対象集団: ALS patients (limited evidence)
Review
Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the …
Dose: Hericium erinaceus (Lion's Mane) extracts
vs: None
Outcome: Neuroprotection and cognitive improvement
効果: None
None
対象集団: Neurodegenerative disease patients (review)
Review
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Key Statistics
4
研究数
250
参加者数
↑
Positive
C
グレード
Referenced Papers
Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications.
Systematic Review
Molecular nutrition & …
2025
8 件の引用
Foods (Basel, Switzerland)
2025
3 件の引用
Psychopharmacology bulletin
2025
Amyotrophic lateral sclerosis …
2024
2 件の引用
Journal of fungi …
2023
44 件の引用
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 件の引用
Journal of fungi …
2021
14 件の引用
Journal of ethnopharmacology
2020
28 件の引用
Journal of biomedical …
2016
98 件の引用
Phytotherapy research : …
2009
227 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 500-3,000 mg/day
- cognitivesupport:
- 1,000-3,000 mg/day of fruiting body extract
上限量： Not established; well-tolerated up to 3,000 mg/day
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| Hericium erinaceus (Lion's Mane) | -- | Neutral | -- |
| Hericium erinaceus (Lion's Mane) extracts | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals; effects observed after 8-16 weeks of consistent use
Safety & Side Effects
報告されている副作用
- ⚠ Mild gastrointestinal discomfort
- ⚠ Skin rash in rare cases (especially with allergies to mushrooms)
- ⚠ Potential itching or tingling sensations
既知の相互作用
- ● Anticoagulants (may have mild antiplatelet effects)
- ● Antidiabetic medications (may lower blood sugar)
- ● Immunosuppressants (may modulate immune function)
耐容上限摂取量： Not established; well-tolerated up to 3,000 mg/day
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Lion's Mane Mushroom help with Brain Fog?
Based on 4 studies with 250 participants, there is limited but promising evidence that Lion's Mane Mushroom may support Brain Fog management. Our evidence grade is C (Some Evidence).
How much Lion's Mane Mushroom should I take for Brain Fog?
Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lion's Mane Mushroom?
Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lion's Mane Mushroom and Brain Fog?
We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 250 total participants. The overall direction of effect is positive.
Related Evidence
Lion's Mane Mushroom 他の症状・状態について
References
- [1] Pin Gong et al.. Mol Nutr Food Res. 2025. Edible and Medicinal Fungi as Candidate Natural Antidepressants: Mechanisms and Nutritional Implications. doi:10.1002/mnfr.70080 PubMed
- [2] Rebecca Galla et al.. Foods. 2025. In Vitro Neuroprotective Effects of a Mixed Extract of Bilberry, Centella asiatica, Hericium erinaceus, and Palmitoylethanolamide. doi:10.3390/foods14152678 PubMed
- [3] Joni F Baker et al.. Psychopharmacol Bull. 2025. Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia. doi:10.64719/pb.4520 PubMed
- [4] Maya Muhanna et al.. Amyotroph Lateral Scler Frontotemporal Degener. 2024. ALSUntangled #73: Lion's Mane. doi:10.1080/21678421.2023.2296557 PubMed
- [5] Federico Brandalise et al.. J Fungi (Basel). 2023. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? doi:10.3390/jof9050551 PubMed
- [6] John E Lewis et al.. J Clin Transl Res. 2021. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. PubMed
- [7] Mihai-Vlad Valu et al.. J Fungi (Basel). 2021. Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment. doi:10.3390/jof7060477 PubMed
- [8] Seul Ki Lee et al.. J Ethnopharmacol. 2020. Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion's mane mushroom (Hericium erinaceus). doi:10.1016/j.jep.2020.113197 PubMed
- [9] Tzeng Tsai-Teng et al.. J Biomed Sci. 2016. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. doi:10.1186/s12929-016-0266-z PubMed
- [10] Koichiro Mori et al.. Phytother Res. 2009. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. doi:10.1002/ptr.2634 PubMed
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