Lion's Mane Mushroom ： Mild Cognitive Impairment (MCI)

Q: Does Lion's Mane Mushroom help with Mild Cognitive Impairment (MCI)?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support Mild Cognitive Impairment (MCI) management. Our evidence grade is B (Good Evidence).

Q: How much Lion's Mane Mushroom should I take for Mild Cognitive Impairment (MCI)?

Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lion's Mane Mushroom?

Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lion's Mane Mushroom and Mild Cognitive Impairment (MCI)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

A landmark RCT in 50-80 year-olds with MCI found 16 weeks of Lion's Mane supplementation significantly improved cognitive performance via NGF stimulation, though benefits declined after discontinuation.

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結論

Key Study Findings

Review

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant …

Dose: None vs: None Outcome: Schizophrenia symptom improvement (theoretical) 効果: None None

対象集団: Patients with chronic/treatment-resistant schizophrenia

Review

ALSUntangled #73: Lion's Mane.

Dose: Hericium erinaceus (Lion's Mane) vs: None Outcome: Neuroprotection and ALS progression 効果: None None

対象集団: ALS patients (limited evidence)

Review

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the …

Dose: Hericium erinaceus (Lion's Mane) extracts vs: None Outcome: Neuroprotection and cognitive improvement 効果: None None

対象集団: Neurodegenerative disease patients (review)

Review

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

In Vitro

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.

Dose: erinacine A-enriched H. erinaceus mycelium (300mg/kg) vs: untreated transgenic mice Outcome: AD pathology markers and neurogenesis 効果: reduced amyloid plaque, increased neurogenesis <0.05

対象集団: APPswe/PS1dE9 transgenic AD mice

Randomized Controlled Trial n=30 2.0 weeks Double-blind

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled …

Dose: 250 mg vs: placebo Outcome: cognitive function 効果: None None

対象集団: dementia patients

Key Statistics

研究数

400

参加者数

↑

Positive

グレード

Referenced Papers

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia. Review

Psychopharmacology bulletin 2025

ALSUntangled #73: Lion's Mane. Other

Amyotrophic lateral sclerosis … 2024 2 件の引用

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? Review

Journal of fungi … 2023 44 件の引用

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Review

Journal of clinical … 2021 38 件の引用

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. Other

Journal of biomedical … 2016 98 件の引用

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. RCT

Phytotherapy research : … 2009 227 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 500-3,000 mg/day
cognitivesupport:: 1,000-3,000 mg/day of fruiting body extract

上限量： Not established; well-tolerated up to 3,000 mg/day

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
Hericium erinaceus (Lion's Mane)	--	Neutral	--
Hericium erinaceus (Lion's Mane) extracts	--	Positive	--
None	--	Mixed	--
erinacine A-enriched H. erinaceus mycelium (300mg/kg)	--	Positive	--
250 mg	2.0 weeks	Positive	30

推奨摂取タイミング： With meals; effects observed after 8-16 weeks of consistent use

Safety & Side Effects

報告されている副作用

⚠ Mild gastrointestinal discomfort
⚠ Skin rash in rare cases (especially with allergies to mushrooms)
⚠ Potential itching or tingling sensations

既知の相互作用

● Anticoagulants (may have mild antiplatelet effects)
● Antidiabetic medications (may lower blood sugar)
● Immunosuppressants (may modulate immune function)

耐容上限摂取量： Not established; well-tolerated up to 3,000 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Lion's Mane Mushroom help with Mild Cognitive Impairment (MCI)?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support Mild Cognitive Impairment (MCI) management. Our evidence grade is B (Good Evidence).

How much Lion's Mane Mushroom should I take for Mild Cognitive Impairment (MCI)?

Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lion's Mane Mushroom?

Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lion's Mane Mushroom and Mild Cognitive Impairment (MCI)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Mild Cognitive Impairment (MCI)

Omega-3 Fatty Acids (DHA/EPA) B

Lion's Mane Mushroom 他の症状・状態について

Memory Loss C Brain Fog C

総合評価

Evidence Strength72%

High confidence

研究の内訳

RCT (1)Meta (0)Other (5)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Mild Cognitive Impairment (MCI)

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。