Lion's Mane Mushroom 用于 轻度认知障碍（MCI）
B 证据 至少一项随机试验支持这一结论，结果基本一致。A landmark RCT in 50-80 year-olds with MCI found 16 weeks of Lion's Mane supplementation significantly improved cognitive performance via NGF stimulation, though benefits declined after discontinuation.
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B
结论
A landmark RCT in 50-80 year-olds with MCI found 16 weeks of Lion's Mane supplementation significantly improved cognitive performance via NGF stimulation, though benefits declined after discontinuation.
Key Study Findings
Review
Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant …
Dose: None
vs: None
Outcome: Schizophrenia symptom improvement (theoretical)
效果: None
None
研究人群: Patients with chronic/treatment-resistant schizophrenia
Review
ALSUntangled #73: Lion's Mane.
Dose: Hericium erinaceus (Lion's Mane)
vs: None
Outcome: Neuroprotection and ALS progression
效果: None
None
研究人群: ALS patients (limited evidence)
Review
Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the …
Dose: Hericium erinaceus (Lion's Mane) extracts
vs: None
Outcome: Neuroprotection and cognitive improvement
效果: None
None
研究人群: Neurodegenerative disease patients (review)
Review
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: None
In Vitro
Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.
Dose: erinacine A-enriched H. erinaceus mycelium (300mg/kg)
vs: untreated transgenic mice
Outcome: AD pathology markers and neurogenesis
效果: reduced amyloid plaque, increased neurogenesis
<0.05
研究人群: APPswe/PS1dE9 transgenic AD mice
Randomized Controlled Trial
n=30
2.0 weeks
Double-blind
Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled …
Dose: 250 mg
vs: placebo
Outcome: cognitive function
效果: None
None
研究人群: dementia patients
Key Statistics
6
研究数量
400
受试者
↑
Positive
B
等级
Referenced Papers
Psychopharmacology bulletin
2025
Amyotrophic lateral sclerosis …
2024
2 次引用
Journal of fungi …
2023
44 次引用
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
2021
38 次引用
Journal of biomedical …
2016
98 次引用
Phytotherapy research : …
2009
227 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 500-3,000 mg/day
- cognitivesupport:
- 1,000-3,000 mg/day of fruiting body extract
上限： Not established; well-tolerated up to 3,000 mg/day
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| Hericium erinaceus (Lion's Mane) | -- | Neutral | -- |
| Hericium erinaceus (Lion's Mane) extracts | -- | Positive | -- |
| None | -- | Mixed | -- |
| erinacine A-enriched H. erinaceus mycelium (300mg/kg) | -- | Positive | -- |
| 250 mg | 2.0 weeks | Positive | 30 |
最佳服用时间： With meals; effects observed after 8-16 weeks of consistent use
Safety & Side Effects
已报告的副作用
- ⚠ Mild gastrointestinal discomfort
- ⚠ Skin rash in rare cases (especially with allergies to mushrooms)
- ⚠ Potential itching or tingling sensations
已知相互作用
- ● Anticoagulants (may have mild antiplatelet effects)
- ● Antidiabetic medications (may lower blood sugar)
- ● Immunosuppressants (may modulate immune function)
可耐受最高摄入量： Not established; well-tolerated up to 3,000 mg/day
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Lion's Mane Mushroom help with 轻度认知障碍（MCI）?
Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support 轻度认知障碍（MCI） management. Our evidence grade is B (Good Evidence).
How much Lion's Mane Mushroom should I take for 轻度认知障碍（MCI）?
Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lion's Mane Mushroom?
Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lion's Mane Mushroom and 轻度认知障碍（MCI）?
We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.
Related Evidence
其他成分用于 轻度认知障碍（MCI）
References
- [1] Joni F Baker et al.. Psychopharmacol Bull. 2025. Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia. doi:10.64719/pb.4520 PubMed
- [2] Maya Muhanna et al.. Amyotroph Lateral Scler Frontotemporal Degener. 2024. ALSUntangled #73: Lion's Mane. doi:10.1080/21678421.2023.2296557 PubMed
- [3] Federico Brandalise et al.. J Fungi (Basel). 2023. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? doi:10.3390/jof9050551 PubMed
- [4] John E Lewis et al.. J Clin Transl Res. 2021. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. PubMed
- [5] Tzeng Tsai-Teng et al.. J Biomed Sci. 2016. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. doi:10.1186/s12929-016-0266-z PubMed
- [6] Koichiro Mori et al.. Phytother Res. 2009. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. doi:10.1002/ptr.2634 PubMed
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