Omega-3 Fatty Acids (DHA/EPA) ： Age-Related Cognitive Decline

A systematic review of 58 studies found each 2,000 mg/day of omega-3 showed significant improvements in attention, perceptual speed, language, and primary memory. Research suggests a non-linear dose-response with optimal effects at moderate doses under 1,700 mg/day.

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結論

Key Study Findings

Systematic Review

Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review.

Dose: None vs: None Outcome: Neurological health outcomes 効果: None None

対象集団: None

Review

Neuroprotective Role of Omega-3 Fatty Acids: Fighting Alzheimer's Disease.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Review

Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.

Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d vs: None Outcome: Cognitive decline in AD 効果: None None

対象集団: Alzheimer's disease patients

Review

Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Review

Nutrition, cognition and chronic kidney disease: A comprehensive review of interactions and interventions.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

In Vitro

Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry.

Dose: None vs: None Outcome: Age-dependent brain lipid changes 効果: None None

対象集団: Mice: adult (3-4mo), middle-aged (10mo), old (19-21mo)

Key Statistics

研究数

12000

参加者数

↑

Positive

グレード

Referenced Papers

Impact of Vegan and Vegetarian Diets on Neurological Health: A Critical Review. Systematic Review

Nutrients 2025 22 件の引用

Advanced nutraceutical approaches to Parkinson's disease: bridging nutrition and neuroprotection. Review

Nutritional neuroscience 2025 14 件の引用

Neuroprotective Role of Omega-3 Fatty Acids: Fighting Alzheimer's Disease. Review

Molecules (Basel, Switzerland) 2025 10 件の引用

Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease. Review

Nutrients 2025 9 件の引用

Nutrition, cognition and chronic kidney disease: A comprehensive review of interactions and interventions. Review

European journal of … 2025 8 件の引用

Multiplatform Lipid Analysis of the Brain of Aging Mice by Mass Spectrometry. Other

Journal of proteome … 2025 8 件の引用

Can supplementation with antioxidants improve cognitive functions in patients with multiple sclerosis? A literature review. Review

Annals of medicine … 2025 3 件の引用

Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches. Review

International journal of … 2025 3 件の引用

Bioactive compounds and dietary patterns in Alzheimer's disease. Review

Journal of Alzheimer's … 2025 3 件の引用

Vitamin D and omega-3 fatty acids attenuate MSG-induced neurodegeneration by modulating tau pathology, neuroinflammation, and VDR expression in rats. Other

Scientific reports 2025 2 件の引用

Coenzyme Q10 and Cognition: A Review. Review

Nutrients 2025 2 件の引用

The Use of Natural Products for Preventing Cognitive Decline/Providing Neuroprotection. Review

Handbook of experimental … 2025 1 件の引用

Effects of plant-derived dietary antioxidants on Alzheimer's disease: Focus on ferroptosis. Review

Asia Pacific journal … 2025 1 件の引用

Targeting Liquid-Liquid Phase Separation and Autophagy in Alzheimer's Disease: Insights into Molecular Mechanisms and Therapeutic Potential. Review

Neurochemical research 2025

Nutritional strategies against dementia in rural populations. Review

Frontiers in nutrition 2025

Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants. Review

Degenerative neurological and … 2024 66 件の引用

Curcumin-loaded polymeric nanomaterials as a novel therapeutic strategy for Alzheimer's disease: A comprehensive review. Review

Ageing research reviews 2024 41 件の引用

Fish and Omega-3 Fatty Acids: Sex and Racial Differences in Cardiovascular Outcomes and Cognitive Function. Review

Arteriosclerosis, thrombosis, and … 2024 12 件の引用

Pharmacodynamic and Clinical Effects of Ginkgo Biloba Extract EGb 761 and Its Phytochemical Components in Alzheimer's Disease. Review

Journal of Alzheimer's … 2024 12 件の引用

The effects of omega-3, DHA, EPA, Souvenaid® in Alzheimer's disease: A systematic review and meta-analysis. Meta-Analysis

Neuropsychopharmacology reports 2024 12 件の引用

Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration. Review

Current Alzheimer research 2024 10 件の引用

Omega-3 fatty acids supplementation prevents learning and memory impairment induced by chronic ethanol consumption in adolescent male rats through restoration … Other

International journal of … 2024 8 件の引用

The Role of Omega-3 Fatty Acid Supplementation in Slowing Cognitive Decline Among Elderly Patients With Alzheimer's Disease: A Systematic Review … Review

Cureus 2024 8 件の引用

Zeaxanthin and Lutein Ameliorate Alzheimer's Disease-like Pathology: Modulation of Insulin Resistance, Neuroinflammation, and Acetylcholinesterase Activity in an Amyloid-β Rat Model. Other

International journal of … 2024 4 件の引用

The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, … Meta-Analysis

The American journal … 2023 106 件の引用

Omega-3 fatty acids and cognitive function. Review

Current opinion in … 2023 58 件の引用

Efficacy and acceptability of anti-inflammatory eicosapentaenoic acid for cognitive function in Alzheimer's dementia: A network meta-analysis of randomized, placebo-controlled trials … Meta-Analysis

Brain, behavior, and … 2023 36 件の引用

Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews. Other

Nutrition reviews 2023 18 件の引用

Vitamin B12 supplementation improves cognitive function in middle aged and elderly patients with cognitive impairment. RCT

Nutricion hospitalaria 2023 13 件の引用

Effects of Long-Chain Polyunsaturated Fatty Acids in Combination with Lutein and Zeaxanthin on Episodic Memory in Healthy Older Adults. RCT

Nutrients 2023 12 件の引用

Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2. Observational

Alzheimer's & dementia … 2023 7 件の引用

Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial. RCT

Clinical nutrition (Edinburgh, … 2022 87 件の引用

Vitamin Supplementation and Dementia: A Systematic Review. Systematic Review

Nutrients 2022 76 件の引用

Omega-3 fatty acids and blood-based biomarkers in Alzheimer's disease and mild cognitive impairment: A randomized placebo-controlled trial. RCT

Brain, behavior, and … 2022 64 件の引用

Dietary and supplemental long-chain omega-3 fatty acids as moderators of cognitive impairment and Alzheimer's disease. Review

European journal of … 2022 63 件の引用

Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging. Review

International journal of … 2022 39 件の引用

Effect of a Vegan Diet on Alzheimer's Disease. Review

International journal of … 2022 23 件の引用

Associations of erythrocyte omega-3 fatty acids with cognition, brain imaging and biomarkers in the Alzheimer's disease neuroimaging initiative: cross-sectional and … Other

The American journal … 2022 18 件の引用

Serum ω-3 Fatty Acids and Cognitive Domains in Community-Dwelling Older Adults from the NuAge Study: Exploring the Associations with Other … Other

The Journal of … 2022 10 件の引用

Neuroprotective Herbs for the Management of Alzheimer's Disease. Review

Biomolecules 2021 161 件の引用

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Review

Journal of clinical … 2021 38 件の引用

Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review. Systematic Review

Journal of alternative … 2021 13 件の引用

Expert Opinion on Benefits of Long-Chain Omega-3 Fatty Acids (DHA and EPA) in Aging and Clinical Nutrition. Review

Nutrients 2020 173 件の引用

Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update. Review

Nutrients 2020 72 件の引用

Blood polyunsaturated omega-3 fatty acids, brain atrophy, cognitive decline, and dementia risk. Other

Alzheimer's & dementia … 2020 43 件の引用

Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity. RCT

The Journal of … 2020 33 件の引用

Centella asiatica Water Extract Shows Low Potential for Cytochrome P450-Mediated Drug Interactions. Other

Drug metabolism and … 2020

Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat … Other

Lipids in health … 2020

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and … Review

Revue neurologique 2019 361 件の引用

Diet and Inflammation in Cognitive Ageing and Alzheimer's Disease. Review

Current nutrition reports 2019 310 件の引用

Omega-3 fatty acids and cognitive decline: a systematic review. Systematic Review

Nutricion hospitalaria 2019 40 件の引用

Combining a high DHA multi-nutrient supplement with aerobic exercise: Protocol for a randomised controlled study assessing mobility and cognitive function … Other

Prostaglandins, leukotrienes, and … 2019 5 件の引用

Diets for Health: Goals and Guidelines. Review

American family physician 2018 101 件の引用

Botanicals and phytochemicals active on cognitive decline: The clinical evidence. Review

Pharmacological research 2018 67 件の引用

[Nutrition strategies that improve cognitive function]. Review

Nutricion hospitalaria 2018 32 件の引用

Effect of Age and Dietary Intervention on Discrimination Learning in Pet Dogs. Other

Frontiers in psychology 2018 13 件の引用

Nutritional Factors Affecting Adult Neurogenesis and Cognitive Function. Review

Advances in nutrition … 2017 215 件の引用

Use of Vitamin E and C Supplements for the Prevention of Cognitive Decline. Other

The Annals of … 2017 73 件の引用

Modulation of innate immunity of patients with Alzheimer's disease by omega-3 fatty acids. Review

FASEB journal : … 2017 41 件の引用

Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and … Review

Biochimica et biophysica … 2017 33 件の引用

Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. Review

Advances in nutrition … 2016 148 件の引用

Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. RCT

Journal of Alzheimer's … 2016 128 件の引用

Nutrient intake, nutritional status, and cognitive function with aging. Review

Annals of the … 2016 89 件の引用

Omega-3 fatty acids and risk of cognitive decline in the elderly: a meta-analysis of randomized controlled trials. Meta-Analysis

Aging clinical and … 2016 55 件の引用

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … RCT

Nutrients 2016 53 件の引用

Novel insights into the effect of vitamin B₁₂ and omega-3 fatty acids on brain function. Review

Journal of biomedical … 2016

Individually modifiable risk factors to ameliorate cognitive aging: a systematic review and meta-analysis. Meta-Analysis

Climacteric : the … 2015 92 件の引用

Protective Effects of Dietary Supplementation with a Combination of Nutrients in a Transgenic Mouse Model of Alzheimer's Disease. Other

PloS one 2015 11 件の引用

n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice. Other

Frontiers in aging … 2014 111 件の引用

The role for dietary omega-3 fatty acids supplementation in older adults. Review

Nutrients 2014 111 件の引用

Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product. RCT

Clinical drug investigation 2014 54 件の引用

Rationale and clinical data supporting nutritional intervention in Alzheimer's disease. Review

Acta clinica Belgica 2014 44 件の引用

Omega-3 fatty acid supplementation and cognitive function: are smaller dosages more beneficial? Other

International journal of … 2014 23 件の引用

[Contribution of omega-3 fatty acids for memory and cognitive function]. Review

Nutricion hospitalaria 2014 17 件の引用

ω-3 fatty acids in the prevention of cognitive decline in humans. Review

Advances in nutrition … 2013 155 件の引用

Omega-3 fatty acids and brain resistance to ageing and stress: body of evidence and possible mechanisms. Review

Ageing research reviews 2013 135 件の引用

The omega-6/omega-3 ratio and dementia or cognitive decline: a systematic review on human studies and biological evidence. Systematic Review

Journal of nutrition … 2013 108 件の引用

ω-3 fatty acids and domain-specific cognitive aging: secondary analyses of data from WHISCA. Other

Neurology 2013 30 件の引用

The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and … RCT

Contemporary clinical trials 2012 522 件の引用

Severe alterations in lipid composition of frontal cortex lipid rafts from Parkinson's disease and incidental Parkinson's disease. Other

Molecular medicine (Cambridge, … 2011 356 件の引用

ω-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depression. Other

Neurobiology of aging 2011 91 件の引用

Reliability and validity of food frequency questionnaire and nutrient biomarkers in elders with and without mild cognitive impairment. Other

Alzheimer disease and … 2011 52 件の引用

Treatment of memory loss with herbal remedies. Other

Current treatment options … 2011 6 件の引用

Why pleiotropic interventions are needed for Alzheimer's disease. Review

Molecular neurobiology 2010 145 件の引用

Omega-3 fatty acids, cognitive decline, and Alzheimer's disease: a critical review and evaluation of the literature. Review

Journal of Alzheimer's … 2010 97 件の引用

A vitamin/nutriceutical formulation improves memory and cognitive performance in community-dwelling adults without dementia. RCT

The journal of … 2010 70 件の引用

Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia? Review

Current opinion in … 2010 60 件の引用

Omega-3 fatty acids and cognitive function in women. Review

Women's health (London, … 2010 48 件の引用

Supplementing cognitive aging: a selective review of the effects of ginkgo biloba and a number of everyday nutritional substances. Review

Experimental aging research 2010 21 件の引用

Ginkgo biloba and cognitive decline. Other

JAMA 2010 3 件の引用

Normal cognitive decline or dementia? Other

The Practitioner 2010

Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association. Systematic Review

Nature clinical practice. … 2009 362 件の引用

Ginkgo biloba for preventing cognitive decline in older adults: a randomized trial. RCT

JAMA 2009 304 件の引用

Ginkgo biloba for cognitive impairment and dementia. Meta-Analysis

The Cochrane database … 2009 299 件の引用

Omega-3 fatty acids and dementia. Review

Prostaglandins, leukotrienes, and … 2009 258 件の引用

Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain … Other

Nutrition research (New … 2009 65 件の引用

Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. RCT

Nutritional neuroscience 2008 277 件の引用

Nutritional biomarkers in Alzheimer's disease: the association between carotenoids, n-3 fatty acids, and dementia severity. Other

Journal of Alzheimer's … 2008 104 件の引用

Herbal drug treatment. Review

Neuro endocrinology letters 2008

Alzheimer's disease, amnestic mild cognitive impairment, and age-associated memory impairment: current understanding and progress toward integrative prevention. Review

Alternative medicine review … 2008

Ginkgo biloba for cognitive impairment and dementia. Meta-Analysis

The Cochrane database … 2007 375 件の引用

Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Review

Alternative medicine review … 2007

Omega-3 fatty acids, energy substrates, and brain function during aging. Review

Prostaglandins, leukotrienes, and … 2006 176 件の引用

Dietary omega-3 Fatty acids and psychiatry: mood, behaviour, stress, depression, dementia and aging. Review

The journal of … 2005 134 件の引用

[Omega-3 fatty acids in psychiatry]. Review

Medecine sciences : … 2005 19 件の引用

Folic acid with or without vitamin B12 for cognition and dementia. Systematic Review

The Cochrane database … 2003 263 件の引用

Omega-3 fatty acids and risk of cognitive impairment and dementia. Other

Journal of Alzheimer's … 2003 161 件の引用

Health benefits of docosahexaenoic acid (DHA). Review

Pharmacological research 1999 1060 件の引用

A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Review

Alternative medicine review … 1999 112 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 1,000-2,000 mg combined DHA/EPA per day
cognitivesupport:: 1,000-1,700 mg/day (optimal dose-response curve)

上限量： 3,000 mg/day combined DHA/EPA (FDA GRAS)

研究で検討された用量

用量	期間	効果	N
None	--	Mixed	--
None	--	Mixed	--
Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--
Vit D 1 mcg/kg + N-3 PUFA 300 mg/kg EPA+DHA	4 weeks	Positive	50
None	--	Mixed	--

推奨摂取タイミング： With meals containing fat for better absorption

Safety & Side Effects

報告されている副作用

⚠ Fishy aftertaste or burping
⚠ Mild gastrointestinal discomfort
⚠ Potential increased bleeding time at very high doses
⚠ May lower blood pressure slightly

既知の相互作用

● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
● Blood pressure medications (additive hypotensive effect)
● Orlistat (may reduce omega-3 absorption)

耐容上限摂取量： 3,000 mg/day combined DHA/EPA (FDA GRAS)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Omega-3 Fatty Acids (DHA/EPA) help with Age-Related Cognitive Decline?

Based on 58 studies with 12,000 participants, there is strong evidence from multiple clinical trials that Omega-3 Fatty Acids (DHA/EPA) may support Age-Related Cognitive Decline management. Our evidence grade is A (Strong Evidence).

How much Omega-3 Fatty Acids (DHA/EPA) should I take for Age-Related Cognitive Decline?

Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?

Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Age-Related Cognitive Decline?

We rate the evidence as Grade A (Strong Evidence). This rating is based on 58 peer-reviewed studies with 12,000 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Age-Related Cognitive Decline

Phosphatidylserine B Bacopa monnieri B Vitamin B12 B Curcumin B Ginkgo biloba C Panax Ginseng C

Omega-3 Fatty Acids (DHA/EPA) 他の症状・状態について

Mild Cognitive Impairment (MCI) B Depression-Related Cognitive Dysfunction B Cerebrovascular Health B Attention & Focus Difficulties C

総合評価

Evidence Strength92%

High confidence

研究の内訳

RCT (12)Meta (7)Other (39)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Age-Related Cognitive Decline

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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。