Resveratrol ： Cerebrovascular Health

Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'braincited.com'; const params = 'ingredient\u003Dresveratrol\u0026condition\u003Dcerebrovascular\u002Dhealth'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

結論

Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.

Key Study Findings

Systematic Review

Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: …

Dose: None vs: None Outcome: effects on glymphatic function, BBB permeability, neuroglial health 効果: None None

対象集団: experimental models and clinical trials on Alzheimer's, Parkinson's, and multiple sclerosis

Review

Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and …

Dose: None vs: None Outcome: None 効果: None None

対象集団: older adults and individuals with neurodegenerative disorders

In Vitro

Resveratrol attenuates the CoCl2-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells.

Dose: None vs: CoCl2-induced hypoxia without resveratrol Outcome: Cell viability and Kbhb modulation under hypoxia 効果: None None

対象集団: PC12 rat pheochromocytoma cells

Review

Natural Products and Exercise Synergy: Unraveling Molecular Mechanisms to Enhance Brain Function in Alzheimer's Disease.

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Controlled Clinical Trial

[Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on …

Dose: 40 or 60 mg/kg vs: CLP group (0.9% NaCl) Outcome: Cerebrovascular endothelial barrier function 効果: None None

対象集団: CLP-induced sepsis-associated encephalopathy mice

Systematic Review

The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review.

Dose: None vs: Placebo or no treatment Outcome: Cardiometabolic changes in menopausal women 効果: None None

対象集団: Menopausal women

Key Statistics

研究数

600

参加者数

↑

Positive

グレード

Referenced Papers

Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: A systematic review. Systematic Review

Brain research 2026 2 件の引用

Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function … Review

Phytotherapy research : … 2026

Resveratrol attenuates the CoCl2-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells. Other

BMC neurology 2025 3 件の引用

The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications. Review

Phytotherapy research : … 2025 1 件の引用

The Nrf2-GPX4 axis mitigates ferroptosis-driven early brain injury in experimental subarachnoid hemorrhage. Other

Brain research 2025 1 件の引用

Varicella Zoster Virus and Stroke: An Intricate Relationship. Review

Viruses 2025 1 件の引用

[Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on network pharmacology and experiment]. Other

Zhongguo Zhong yao … 2025

The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. Other

Cardiovascular & hematological … 2025

Natural Products and Exercise Synergy: Unraveling Molecular Mechanisms to Enhance Brain Function in Alzheimer's Disease. Review

Phytotherapy research : … 2025

Resveratrol restores indices of neurovascular coupling following acute sleep restriction in young men and women. Other

Journal of applied … 2025

Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics. Review

Frontiers in pharmacology 2024 14 件の引用

Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine. Other

International journal of … 2024 1 件の引用

Reveal the correlation between hub hypoxia/immune-related genes and immunity and diagnosis, and the effect of SAP30 on cell apoptosis, ROS … Other

Aging 2023 3 件の引用

Exploring the effects of resveratrol supplementation on cerebrovascular function in hormonal migraineurs: A pilot study. Other

IBRO neuroscience reports 2023 1 件の引用

The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review. Systematic Review

Journal of medicinal … 2022 48 件の引用

Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases. Review

Frontiers in pharmacology 2022 37 件の引用

Resveratrol inhibiting TGF/ERK signaling pathway can improve atherosclerosis: backgrounds, mechanisms and effects. Review

Biomedicine & pharmacotherapy … 2022 34 件の引用

SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency. Other

Cellular and molecular … 2022 20 件の引用

Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies. Systematic Review

Phytotherapy research : … 2022 13 件の引用

Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway. Other

Acta biochimica Polonica 2022 10 件の引用

A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine. RCT

Nutrients 2022 9 件の引用

Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis. Other

Nutrients 2022 2 件の引用

Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover … RCT

Clinical nutrition (Edinburgh, … 2021 54 件の引用

The Role of Resveratrol Administration in Human Obesity. Review

International journal of … 2021 50 件の引用

Traditional Chinese Medicine Monomers: Novel Strategy for Endogenous Neural Stem Cells Activation After Stroke. Review

Frontiers in cellular … 2021 40 件の引用

Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. RCT

Journal of bone … 2020 120 件の引用

Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Other

Nutrients 2020 49 件の引用

Resveratrol ameliorates brain injury via the TGF-β-mediated ERK signaling pathway in a rat model of cerebral hemorrhage. Other

Experimental and therapeutic … 2019 25 件の引用

Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mechanisms of Neuroprotection. Review

International journal of … 2019 11 件の引用

Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise. Review

Nutrients 2018 108 件の引用

Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. Review

Nutrients 2018 77 件の引用

Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease. Review

The American journal … 2018 29 件の引用

Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults. Other

Frontiers in aging … 2018 23 件の引用

Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial. RCT

Nutrients 2017 149 件の引用

Dietary Polyphenols in the Prevention of Stroke. Review

Oxidative medicine and … 2017 87 件の引用

Resveratrol supplementation reduces pain experience by postmenopausal women. RCT

Menopause (New York, … 2017 47 件の引用

Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus. RCT

Nutrition, metabolism, and … 2016 85 件の引用

Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. RCT

Nutrients 2016 83 件の引用

Clinical Evaluation of Effects of Chronic Resveratrol Supplementation on Cerebrovascular Function, Cognition, Mood, Physical Function and General Well-Being in Postmenopausal … RCT

Nutrients 2016 38 件の引用

[The role of resveratrol in the regulation of cell metabolism--a review]. Review

Postepy higieny i … 2016 13 件の引用

Resveratrol attenuates high-fat diet-induced disruption of the blood-brain barrier and protects brain neurons from apoptotic insults. Other

Journal of agricultural … 2014 58 件の引用

Role of red grape polyphenols as antidiabetic agents. Review

Integrative medicine research 2014 51 件の引用

Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. Review

Food and chemical … 2013 188 件の引用

Evidence for circulatory benefits of resveratrol in humans. Review

Annals of the … 2013 31 件の引用

Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells. Other

Journal of cerebral … 2011 61 件の引用

Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. Other

American journal of … 2011 60 件の引用

Ageing and neurodegenerative diseases. Review

Ageing research reviews 2010 228 件の引用

Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to … Other

The Journal of … 2010 83 件の引用

Longevity nutrients resveratrol, wines and grapes. Other

Genes & nutrition 2010 64 件の引用

Grapes, wines, resveratrol, and heart health. Review

Journal of cardiovascular … 2009 297 件の引用

Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies. Review

Alcoholism, clinical and … 2009 238 件の引用

Resveratrol preserves cerebrovascular density and cognitive function in aging mice. Other

Frontiers in aging … 2009

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 150-500 mg/day trans-resveratrol
cognitivesupport:: 200-500 mg/day

上限量： 5,000 mg/day (highest dose in clinical trials)

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
40 or 60 mg/kg	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
250 mg single dose	--	Positive	16

推奨摂取タイミング： With meals containing fat; morning preferred

Safety & Side Effects

報告されている副作用

⚠ Gastrointestinal discomfort
⚠ Headache
⚠ Diarrhea at high doses

既知の相互作用

● Anticoagulants (may increase bleeding risk)
● CYP450 substrates (affects drug metabolism)
● Estrogen-sensitive conditions (weak estrogenic activity)

耐容上限摂取量： 5,000 mg/day (highest dose in clinical trials)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Resveratrol help with Cerebrovascular Health?

Based on 8 studies with 600 participants, there is limited but promising evidence that Resveratrol may support Cerebrovascular Health management. Our evidence grade is C (Some Evidence).

How much Resveratrol should I take for Cerebrovascular Health?

Studies have used various dosages. A commonly studied range is 150-500 mg/day trans-resveratrol. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort, Headache, Diarrhea at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Resveratrol and Cerebrovascular Health?

We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Cerebrovascular Health

Omega-3 Fatty Acids (DHA/EPA) B Ginkgo biloba B

総合評価

Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (8)Meta (0)Other (0)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Cerebrovascular Health

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。