Resveratrol para Cerebrovascular Health
C Evidencia Evidencia limitada de estudios pequeños, pero existen algunas señales positivas.Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.
<\/script>\n`;
},
get iframeSnippet() {
const domain = 'braincited.com';
const params = 'ingredient\u003Dresveratrol\u0026condition\u003Dcerebrovascular\u002Dhealth';
return ``;
},
get activeSnippet() {
return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet;
},
copySnippet() {
navigator.clipboard.writeText(this.activeSnippet).then(() => {
this.copied = true;
setTimeout(() => { this.copied = false; }, 2000);
});
}
}"
@keydown.escape.window="open = false"
@click.outside="open = false">
C
Conclusión
Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.
Key Study Findings
Systematic Review
Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: …
Dose: None
vs: None
Outcome: effects on glymphatic function, BBB permeability, neuroglial health
Efecto: None
None
Población: experimental models and clinical trials on Alzheimer's, Parkinson's, and multiple sclerosis
Review
Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and …
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: older adults and individuals with neurodegenerative disorders
In Vitro
Resveratrol attenuates the CoCl2-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells.
Dose: None
vs: CoCl2-induced hypoxia without resveratrol
Outcome: Cell viability and Kbhb modulation under hypoxia
Efecto: None
None
Población: PC12 rat pheochromocytoma cells
Review
Varicella Zoster Virus and Stroke: An Intricate Relationship.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: None
Controlled Clinical Trial
[Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on …
Dose: 40 or 60 mg/kg
vs: CLP group (0.9% NaCl)
Outcome: Cerebrovascular endothelial barrier function
Efecto: None
None
Población: CLP-induced sepsis-associated encephalopathy mice
Review
The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications.
Dose: None
vs: None
Outcome: None
Efecto: None
None
Población: Review of flavonoids/phenolics in diabetic macrovascular
Key Statistics
8
Estudios
600
Participantes
↑
Positive
C
Calificación
Referenced Papers
Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: A systematic review.
Systematic Review
Brain research
2026
2 citas
Phytotherapy research : …
2026
BMC neurology
2025
3 citas
Phytotherapy research : …
2025
1 citas
Brain research
2025
1 citas
Viruses
2025
1 citas
Zhongguo Zhong yao …
2025
Cardiovascular & hematological …
2025
Phytotherapy research : …
2025
Journal of applied …
2025
Frontiers in pharmacology
2024
14 citas
International journal of …
2024
1 citas
Aging
2023
3 citas
IBRO neuroscience reports
2023
1 citas
The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.
Systematic Review
Journal of medicinal …
2022
48 citas
Frontiers in pharmacology
2022
37 citas
Biomedicine & pharmacotherapy …
2022
34 citas
Cellular and molecular …
2022
20 citas
Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies.
Systematic Review
Phytotherapy research : …
2022
13 citas
Acta biochimica Polonica
2022
10 citas
Nutrients
2022
9 citas
Nutrients
2022
2 citas
Clinical nutrition (Edinburgh, …
2021
54 citas
International journal of …
2021
50 citas
Frontiers in cellular …
2021
40 citas
Journal of bone …
2020
120 citas
Nutrients
2020
49 citas
Experimental and therapeutic …
2019
25 citas
International journal of …
2019
11 citas
Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise.
Review
Nutrients
2018
108 citas
Nutrients
2018
77 citas
The American journal …
2018
29 citas
Frontiers in aging …
2018
23 citas
Nutrients
2017
149 citas
Oxidative medicine and …
2017
87 citas
Menopause (New York, …
2017
47 citas
Nutrition, metabolism, and …
2016
85 citas
Nutrients
2016
83 citas
Nutrients
2016
38 citas
Postepy higieny i …
2016
13 citas
Journal of agricultural …
2014
58 citas
Integrative medicine research
2014
51 citas
Food and chemical …
2013
188 citas
Annals of the …
2013
31 citas
Journal of cerebral …
2011
61 citas
American journal of …
2011
60 citas
Ageing research reviews
2010
228 citas
The Journal of …
2010
83 citas
Genes & nutrition
2010
64 citas
Journal of cardiovascular …
2009
297 citas
Alcoholism, clinical and …
2009
238 citas
Frontiers in aging …
2009
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosificaciones de uso común
- general:
- 150-500 mg/day trans-resveratrol
- cognitivesupport:
- 200-500 mg/day
Límite superior: 5,000 mg/day (highest dose in clinical trials)
Dosificaciones estudiadas en la investigación
| Dosificación | Duración | Efecto | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| 40 or 60 mg/kg | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
Mejor momento para tomar: With meals containing fat; morning preferred
Safety & Side Effects
Efectos secundarios reportados
- ⚠ Gastrointestinal discomfort
- ⚠ Headache
- ⚠ Diarrhea at high doses
Interacciones conocidas
- ● Anticoagulants (may increase bleeding risk)
- ● CYP450 substrates (affects drug metabolism)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
Ingesta máxima tolerable: 5,000 mg/day (highest dose in clinical trials)
Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.
Frequently Asked Questions
Does Resveratrol help with Cerebrovascular Health?
Based on 8 studies with 600 participants, there is limited but promising evidence that Resveratrol may support Cerebrovascular Health management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Cerebrovascular Health?
Studies have used various dosages. A commonly studied range is 150-500 mg/day trans-resveratrol. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort, Headache, Diarrhea at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Cerebrovascular Health?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
Otros ingredientes para Cerebrovascular Health
References
- [1] Renee Grandi et al.. Brain Res. 2026. Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: A systematic review. doi:10.1016/j.brainres.2025.150046 PubMed
- [2] Lei Wang et al.. Phytother Res. 2026. Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and Their Association With Cognitive Function … doi:10.1002/ptr.70198 PubMed
- [3] Yamei Wang et al.. BMC Neurol. 2025. Resveratrol attenuates the CoCl2-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells. doi:10.1186/s12883-025-04171-y PubMed
- [4] Aminu Mohammed et al.. Phytother Res. 2025. The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications. doi:10.1002/ptr.70070 PubMed
- [5] Jian Zhou et al.. Brain Res. 2025. The Nrf2-GPX4 axis mitigates ferroptosis-driven early brain injury in experimental subarachnoid hemorrhage. doi:10.1016/j.brainres.2025.149761 PubMed
- [6] Achilleas Livieratos et al.. Viruses. 2025. Varicella Zoster Virus and Stroke: An Intricate Relationship. doi:10.3390/v17121591 PubMed
- [7] Rong Li et al.. Zhongguo Zhong Yao Za Zhi. 2025. [Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on network pharmacology and experiment]. doi:10.19540/j.cnki.cjcmm.20241012.301 PubMed
- [8] Ali Amini et al.. Cardiovasc Hematol Disord Drug Targets. 2025. The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. doi:10.2174/011871529X398468250910225946 PubMed
- [9] Long Chen et al.. Phytother Res. 2025. Natural Products and Exercise Synergy: Unraveling Molecular Mechanisms to Enhance Brain Function in Alzheimer's Disease. doi:10.1002/ptr.70005 PubMed
- [10] Matthew J McDonald et al.. J Appl Physiol (1985). 2025. Resveratrol restores indices of neurovascular coupling following acute sleep restriction in young men and women. doi:10.1152/japplphysiol.00402.2025 PubMed
- [11] Liu Peng et al.. Front Pharmacol. 2024. Therapeutic potential of resveratrol through ferroptosis modulation: insights and future directions in disease therapeutics. doi:10.3389/fphar.2024.1473939 PubMed
- [12] Jemima S A Dzator et al.. Int J Mol Sci. 2024. Associations between Cerebrovascular Function and the Expression of Genes Related to Endothelial Function in Hormonal Migraine. doi:10.3390/ijms25031694 PubMed
- [13] Yue Cao et al.. Aging (Albany NY). 2023. Reveal the correlation between hub hypoxia/immune-related genes and immunity and diagnosis, and the effect of SAP30 on cell apoptosis, ROS … doi:10.18632/aging.205339 PubMed
- [14] Jemima S A Dzator et al.. IBRO Neurosci Rep. 2023. Exploring the effects of resveratrol supplementation on cerebrovascular function in hormonal migraineurs: A pilot study. doi:10.1016/j.ibneur.2023.10.005 PubMed
- [15] Daiene Santos Buglio et al.. J Med Food. 2022. The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review. doi:10.1089/jmf.2021.0084 PubMed
- [16] Qing Wang et al.. Front Pharmacol. 2022. Antioxidant and neuroprotective actions of resveratrol in cerebrovascular diseases. doi:10.3389/fphar.2022.948889 PubMed
- [17] Shitian Guo et al.. Biomed Pharmacother. 2022. Resveratrol inhibiting TGF/ERK signaling pathway can improve atherosclerosis: backgrounds, mechanisms and effects. doi:10.1016/j.biopha.2022.113775 PubMed
- [18] Albino Carrizzo et al.. Cell Mol Life Sci. 2022. SIRT1 pharmacological activation rescues vascular dysfunction and prevents thrombosis in MTHFR deficiency. doi:10.1007/s00018-022-04429-5 PubMed
- [19] Lucia E Schimith et al.. Phytother Res. 2022. Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies. doi:10.1002/ptr.7497 PubMed
- [20] Tao Jin et al.. Acta Biochim Pol. 2022. Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway. doi:10.18388/abp.2020_5982 PubMed
- [21] Jemima S A Dzator et al.. Nutrients. 2022. A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine. doi:10.3390/nu14091763 PubMed
- [22] Meiming Su et al.. Nutrients. 2022. Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis. doi:10.3390/nu14214518 PubMed
- [23] Jay Jay Thaung Zaw et al.. Clin Nutr. 2021. Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover … doi:10.1016/j.clnu.2020.08.025 PubMed
- [24] Laura M Mongioì et al.. Int J Mol Sci. 2021. The Role of Resveratrol Administration in Human Obesity. doi:10.3390/ijms22094362 PubMed
- [25] Ju Wang et al.. Front Cell Neurosci. 2021. Traditional Chinese Medicine Monomers: Novel Strategy for Endogenous Neural Stem Cells Activation After Stroke. doi:10.3389/fncel.2021.628115 PubMed
- [26] Rachel Hx Wong et al.. J Bone Miner Res. 2020. Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial. doi:10.1002/jbmr.4115 PubMed
- [27] Jay Jay Thaung Zaw et al.. Nutrients. 2020. Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. doi:10.3390/nu12030828 PubMed
- [28] Riguang Zhao et al.. Exp Ther Med. 2019. Resveratrol ameliorates brain injury via the TGF-β-mediated ERK signaling pathway in a rat model of cerebral hemorrhage. doi:10.3892/etm.2019.7939 PubMed
- [29] Donatella Pastore et al.. Int J Mol Sci. 2019. Age-Dependent Levels of Protein Kinase Cs in Brain: Reduction of Endogenous Mechanisms of Neuroprotection. doi:10.3390/ijms20143544 PubMed
- [30] Peter J Joris et al.. Nutrients. 2018. Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise. doi:10.3390/nu10050530 PubMed
- [31] Michał Wiciński et al.. Nutrients. 2018. Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions. doi:10.3390/nu10111813 PubMed
- [32] Yueying Li et al.. Am J Chin Med. 2018. Pharmacological Effects and Mechanisms of Chinese Medicines Modulating NLRP3 Inflammasomes in Ischemic Cardio/Cerebral Vascular Disease. doi:10.1142/S0192415X18500878 PubMed
- [33] Jeffery M Reddan et al.. Front Aging Neurosci. 2018. Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults. doi:10.3389/fnagi.2018.00049 PubMed
- [34] Hamish M Evans et al.. Nutrients. 2017. Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial. doi:10.3390/nu9010027 PubMed
- [35] A Tressera-Rimbau et al.. Oxid Med Cell Longev. 2017. Dietary Polyphenols in the Prevention of Stroke. doi:10.1155/2017/7467962 PubMed
- [36] Rachel H X Wong et al.. Menopause. 2017. Resveratrol supplementation reduces pain experience by postmenopausal women. doi:10.1097/GME.0000000000000861 PubMed
- [37] R H X Wong et al.. Nutr Metab Cardiovasc Dis. 2016. Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus. doi:10.1016/j.numecd.2016.03.003 PubMed
- [38] Rachel H X Wong et al.. Nutrients. 2016. Acute Resveratrol Consumption Improves Neurovascular Coupling Capacity in Adults with Type 2 Diabetes Mellitus. doi:10.3390/nu8070425 PubMed
- [39] Hamish Michael Evans et al.. Nutrients. 2016. Clinical Evaluation of Effects of Chronic Resveratrol Supplementation on Cerebrovascular Function, Cognition, Mood, Physical Function and General Well-Being in Postmenopausal … doi:10.3390/nu8030150 PubMed
- [40] Marek Pieszka et al.. Postepy Hig Med Dosw (Online). 2016. [The role of resveratrol in the regulation of cell metabolism--a review]. doi:10.5604/17322693.1195844 PubMed
- [41] Huai-Chia Chang et al.. J Agric Food Chem. 2014. Resveratrol attenuates high-fat diet-induced disruption of the blood-brain barrier and protects brain neurons from apoptotic insults. doi:10.1021/jf403286w PubMed
- [42] Kanti Bhooshan Pandey et al.. Integr Med Res. 2014. Role of red grape polyphenols as antidiabetic agents. doi:10.1016/j.imr.2014.06.001 PubMed
- [43] Albino Carrizzo et al.. Food Chem Toxicol. 2013. Antioxidant effects of resveratrol in cardiovascular, cerebral and metabolic diseases. doi:10.1016/j.fct.2013.07.021 PubMed
- [44] Rachel H X Wong et al.. Ann N Y Acad Sci. 2013. Evidence for circulatory benefits of resveratrol in humans. doi:10.1111/nyas.12155 PubMed
- [45] Huai-Chia Chang et al.. J Cereb Blood Flow Metab. 2011. Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells. doi:10.1038/jcbfm.2010.180 PubMed
- [46] Denise M Arrick et al.. Am J Physiol Heart Circ Physiol. 2011. Chronic resveratrol treatment restores vascular responsiveness of cerebral arterioles in type 1 diabetic rats. doi:10.1152/ajpheart.00312.2011 PubMed
- [47] Chia-Wei Hung et al.. Ageing Res Rev. 2010. Ageing and neurodegenerative diseases. doi:10.1016/j.arr.2010.08.006 PubMed
- [48] Yi-Ling Lin et al.. J Nutr. 2010. Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to … doi:10.3945/jn.110.123505 PubMed
- [49] Istvan Lekli et al.. Genes Nutr. 2010. Longevity nutrients resveratrol, wines and grapes. doi:10.1007/s12263-009-0145-2 PubMed
- [50] Alberto A A Bertelli et al.. J Cardiovasc Pharmacol. 2009. Grapes, wines, resveratrol, and heart health. doi:10.1097/FJC.0b013e3181bfaff3 PubMed
- [51] Michael A Collins et al.. Alcohol Clin Exp Res. 2009. Alcohol in moderation, cardioprotection, and neuroprotection: epidemiological considerations and mechanistic studies. doi:10.1111/j.1530-0277.2008.00828.x PubMed
- [52] Charlotte A Oomen et al.. Front Aging Neurosci. 2009. Resveratrol preserves cerebrovascular density and cognitive function in aging mice. doi:10.3389/neuro.24.004.2009 PubMed
Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.