Resveratrol ： Cerebrovascular Health
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.
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C
結論
Research suggests resveratrol may improve cerebral blood flow through nitric oxide-mediated vasodilation and activation of neuroprotective SIRT1 pathways. Bioavailability remains a key challenge.
Key Study Findings
Systematic Review
Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: …
Dose: None
vs: None
Outcome: effects on glymphatic function, BBB permeability, neuroglial health
効果: None
None
対象集団: experimental models and clinical trials on Alzheimer's, Parkinson's, and multiple sclerosis
Review
Dietary Antioxidants, Polyphenols, and Vascular Health: Insights From Ultrasound Measurement of Carotid Intima-Media Thickness and …
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: older adults and individuals with neurodegenerative disorders
In Vitro
Resveratrol attenuates the CoCl2-induced hypoxia damage by regulation of lysine β-hydroxybutyrylation in PC12 cells.
Dose: None
vs: CoCl2-induced hypoxia without resveratrol
Outcome: Cell viability and Kbhb modulation under hypoxia
効果: None
None
対象集団: PC12 rat pheochromocytoma cells
Review
Varicella Zoster Virus and Stroke: An Intricate Relationship.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Controlled Clinical Trial
[Verification of resveratrol ameliorating vascular endothelial damage in sepsis-associated encephalopathy through HIF-1α pathway based on …
Dose: 40 or 60 mg/kg
vs: CLP group (0.9% NaCl)
Outcome: Cerebrovascular endothelial barrier function
効果: None
None
対象集団: CLP-induced sepsis-associated encephalopathy mice
Review
The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: Review of flavonoids/phenolics in diabetic macrovascular
Key Statistics
8
研究数
600
参加者数
↑
Positive
C
グレード
Referenced Papers
Investigating the impact of resveratrol and quercetin on glymphatic function, blood-brain barrier, and neuroglial health: A systematic review.
Systematic Review
Brain research
2026
2 件の引用
Phytotherapy research : …
2026
BMC neurology
2025
3 件の引用
Phytotherapy research : …
2025
1 件の引用
Brain research
2025
1 件の引用
Viruses
2025
1 件の引用
Zhongguo Zhong yao …
2025
Cardiovascular & hematological …
2025
Phytotherapy research : …
2025
Journal of applied …
2025
Frontiers in pharmacology
2024
14 件の引用
International journal of …
2024
1 件の引用
Aging
2023
3 件の引用
IBRO neuroscience reports
2023
1 件の引用
The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review.
Systematic Review
Journal of medicinal …
2022
48 件の引用
Frontiers in pharmacology
2022
37 件の引用
Biomedicine & pharmacotherapy …
2022
34 件の引用
Cellular and molecular …
2022
20 件の引用
Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies.
Systematic Review
Phytotherapy research : …
2022
13 件の引用
Acta biochimica Polonica
2022
10 件の引用
Nutrients
2022
9 件の引用
Nutrients
2022
2 件の引用
Clinical nutrition (Edinburgh, …
2021
54 件の引用
International journal of …
2021
50 件の引用
Frontiers in cellular …
2021
40 件の引用
Journal of bone …
2020
120 件の引用
Nutrients
2020
49 件の引用
Experimental and therapeutic …
2019
25 件の引用
International journal of …
2019
11 件の引用
Cerebral Blood Flow Measurements in Adults: A Review on the Effects of Dietary Factors and Exercise.
Review
Nutrients
2018
108 件の引用
Nutrients
2018
77 件の引用
The American journal …
2018
29 件の引用
Frontiers in aging …
2018
23 件の引用
Nutrients
2017
149 件の引用
Oxidative medicine and …
2017
87 件の引用
Menopause (New York, …
2017
47 件の引用
Nutrition, metabolism, and …
2016
85 件の引用
Nutrients
2016
83 件の引用
Nutrients
2016
38 件の引用
Postepy higieny i …
2016
13 件の引用
Journal of agricultural …
2014
58 件の引用
Integrative medicine research
2014
51 件の引用
Food and chemical …
2013
188 件の引用
Annals of the …
2013
31 件の引用
Journal of cerebral …
2011
61 件の引用
American journal of …
2011
60 件の引用
Ageing research reviews
2010
228 件の引用
The Journal of …
2010
83 件の引用
Genes & nutrition
2010
64 件の引用
Journal of cardiovascular …
2009
297 件の引用
Alcoholism, clinical and …
2009
238 件の引用
Frontiers in aging …
2009
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 150-500 mg/day trans-resveratrol
- cognitivesupport:
- 200-500 mg/day
上限量： 5,000 mg/day (highest dose in clinical trials)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| 40 or 60 mg/kg | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
推奨摂取タイミング： With meals containing fat; morning preferred
Safety & Side Effects
報告されている副作用
- ⚠ Gastrointestinal discomfort
- ⚠ Headache
- ⚠ Diarrhea at high doses
既知の相互作用
- ● Anticoagulants (may increase bleeding risk)
- ● CYP450 substrates (affects drug metabolism)
- ● Estrogen-sensitive conditions (weak estrogenic activity)
耐容上限摂取量： 5,000 mg/day (highest dose in clinical trials)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Resveratrol help with Cerebrovascular Health?
Based on 8 studies with 600 participants, there is limited but promising evidence that Resveratrol may support Cerebrovascular Health management. Our evidence grade is C (Some Evidence).
How much Resveratrol should I take for Cerebrovascular Health?
Studies have used various dosages. A commonly studied range is 150-500 mg/day trans-resveratrol. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Resveratrol?
Reported side effects may include Gastrointestinal discomfort, Headache, Diarrhea at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Resveratrol and Cerebrovascular Health?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Cerebrovascular Health
References
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