Uridine Monophosphate ： Neurotransmitter Imbalance

The uridine + DHA + choline combination (known as the 'Mr. Happy Stack') provides synergistic support for phospholipid synthesis and dopamine receptor expression. Limited but promising clinical evidence.

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結論

Key Study Findings

Observational Study

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation.

Dose: None vs: None Outcome: None 効果: None None

対象集団: Dogs with intervertebral disc herniation

In Vitro

The Effects of Semen Ziziphi Spinosae Extract on LPS-Induced Astrocyte Gene Expression and Metabolites.

Dose: None vs: LPS-treated astrocyte controls Outcome: Astrocyte gene expression and metabolite changes 効果: None None

対象集団: LPS-induced inflammatory astrocyte model

Review

Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the …

Dose: None vs: None Outcome: None 効果: None None

対象集団: None

Other

1H and 31P magnetic resonance spectroscopy reveals potential pathogenic and biomarker metabolite alterations in Lafora …

Dose: None vs: None Outcome: None 効果: None P = 0.013

対象集団: Healthy adults

Other 4 weeks

Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling …

Dose: 5 mg/kg vs: None Outcome: Cognitive function 効果: None None

対象集団: Sprague Dawley rats

In Vitro

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old Precocious Mechanism in …

Dose: 1 g vs: None Outcome: None 効果: None None

対象集団: None

Key Statistics

研究数

300

参加者数

↑

Positive

グレード

Referenced Papers

Combining Metabolomics and Proteomics to Reveal Key Serum Compounds Related to Canine Intervertebral Disc Herniation. Other

Metabolites 2025

The Effects of Semen Ziziphi Spinosae Extract on LPS-Induced Astrocyte Gene Expression and Metabolites. Other

Nutrients 2025

Involvement of uridine in brain and gut health: insights into its neuroprotective potential via the gut-brain axis. Review

Pharmacological reports : … 2025

Jujuboside A Regulates Calcium Homeostasis and Structural Plasticity to Alleviate Depression-Like Behavior via Shh Signaling in Immature Neurons. Other

Drug design, development … 2024 8 件の引用

1H and 31P magnetic resonance spectroscopy reveals potential pathogenic and biomarker metabolite alterations in Lafora disease. Other

Brain communications 2024 8 件の引用

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old Precocious Mechanism in the Chinese Mitten Crab, Eriocheir … Other

International journal of … 2023 12 件の引用

Citicoline for Supporting Memory in Aging Humans. Review

Aging and disease 2023 9 件の引用

Expanded tRNA methyltransferase family member TRMT9B regulates synaptic growth and function. Other

EMBO reports 2023 5 件の引用

The G Protein-Coupled Serotonin 1A Receptor Augments Protein Kinase Cε-Mediated Neurogenesis in Neonatal Mouse Hippocampus-PKCε-Mediated Signaling in the Early Hippocampus. Other

International journal of … 2022 4 件の引用

Region-specific metabolic characterization of the type 1 diabetic brain in mice with and without cognitive impairment. Other

Neurochemistry international 2021 12 件の引用

ATP as a cotransmitter in sympathetic and parasympathetic nerves - another Burnstock legacy. Other

Autonomic neuroscience : … 2021 9 件の引用

Dexamethasone-Induced Perturbations in Tissue Metabolomics Revealed by Chemical Isotope Labeling LC-MS analysis. Other

Metabolites 2020 29 件の引用

Vortioxetine: Clinical Pharmacokinetics and Drug Interactions. Review

Clinical pharmacokinetics 2018 128 件の引用

Loss of nitric oxide-mediated inhibition of purine neurotransmitter release in the colon in the absence of interstitial cells of Cajal. Other

American journal of … 2017 14 件の引用

Synapse formation in the brain can be enhanced by co-administering three specific nutrients. Other

European journal of … 2017 9 件の引用

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease. Other

Neurobiology of disease 2016 83 件の引用

Purinergic transmission in blood vessels. Review

Autonomic neuroscience : … 2015 81 件の引用

Exercise but not (-)-epigallocatechin-3-gallate or β-alanine enhances physical fitness, brain plasticity, and behavioral performance in mice. Other

Physiology & behavior 2015 45 件の引用

Optimising nutrition to improve growth and reduce neurodisabilities in neonates at risk of neurological impairment, and children with suspected or … RCT

BMC pediatrics 2015 15 件の引用

Intestinal epithelial stem/progenitor cells are controlled by mucosal afferent nerves. Other

PloS one 2011 62 件の引用

Non-nutritional uses of nutrients. Review

European journal of … 2011 16 件の引用

Neurotransmitter synthesis in poststroke cortical neurogenesis in adult rats. Other

Stem cell research 2010 18 件の引用

Dopamine receptor activation promotes adult neurogenesis in an acute Parkinson model. Other

Experimental neurology 2009 170 件の引用

Use of phosphatide precursors to promote synaptogenesis. Review

Annual review of … 2009 141 件の引用

Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses. Review

Alzheimer's & dementia … 2008 96 件の引用

Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils. Other

FASEB journal : … 2008 95 件の引用

Histamine induces neural stem cell proliferation and neuronal differentiation by activation of distinct histamine receptors. Other

Journal of neurochemistry 2008 91 件の引用

Small-interfering-RNA-mediated silencing of human glutamate dehydrogenase induces apoptosis in neuroblastoma cells. Other

Biotechnology and applied … 2008 7 件の引用

HVC interneurons are not renewed in adult male zebra finches. Other

The European journal … 2007 55 件の引用

Expression of the homeodomain transcription factor Meis2 in the embryonic and postnatal retina. Other

The Journal of … 2007 36 件の引用

Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats. Other

Journal of molecular … 2005 66 件の引用

P2X and P2Y receptors as possible targets of therapeutic manipulations in CNS illnesses. Review

Drug news & … 2005 43 件の引用

Disruption of rat forebrain development by glucocorticoids: critical perinatal periods for effects on neural cell acquisition and on cell signaling … Other

Neuropsychopharmacology : official … 2005 39 件の引用

Serotonergic stimulation of corticotropin-releasing hormone and pro-opiomelanocortin gene expression. Other

Journal of neuroendocrinology 2002 83 件の引用

Astrocytic and microglia cells reactivity induced by neonatal administration of glutamate in cerebral cortex of the adult rats. Other

Journal of neuroscience … 2002 58 件の引用

Severe pyridine nucleotide depletion in fibroblasts from Lesch-Nyhan patients. Other

The Biochemical journal 2002 43 件の引用

Calcium-dependent regulation of cholinergic cell phenotype in the hypothalamus in vitro. Other

Journal of neurophysiology 2002 27 件の引用

Is there a role for uridine and pyrimidine nucleosides in the treatment of vascular dementia? Review

Functional neurology 2002

Identification and characterization of neuronal precursors and their progeny from human fetal tissue. Other

Journal of neuroscience … 2001 76 件の引用

Pregnenolone sulfate and aging of cognitive functions: behavioral, neurochemical, and morphological investigations. Other

Hormones and behavior 2001 45 件の引用

Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen. Other

The Journal of … 2000 745 件の引用

Expression and regulation of P2U-purinergic receptor in human granulosa-luteal cells. Other

The Journal of … 2000

Uridine activates fast transmembrane Ca2+ ion fluxes in rat brain homogenates. Other

Neuroreport 1999 32 件の引用

GABA, GAD, and GABA(A) receptor alpha4, beta1, and gamma1 subunits are expressed in the late embryonic and early postnatal neocortical … Other

Microscopy research and … 1998 26 件の引用

Neurogenesis and cell migration into the sexually dimorphic preoptic area/anterior hypothalamus of the fetal ferret. Other

Journal of neurobiology 1996 45 件の引用

In vitro properties of a newly established medulloblastoma cell line, MCD-1. Other

Molecular and chemical … 1996 17 件の引用

Ethanol neurotoxicity in culture: selective loss of cholinergic neurons. Other

Journal of neuroscience … 1996 16 件の引用

Sleep as neuronal detoxification and restitution. Review

Behavioural brain research 1995 146 件の引用

Laminin and a basement membrane extract have different effects on axonal and dendritic outgrowth from embryonic rat sympathetic neurons in … Other

Developmental biology 1989 100 件の引用

Adrenal steroids as modulators of nerve cell function. Review

Journal of steroid … 1984 22 件の引用

Neurons from fetal rat brain in a new cell culture system: a multidisciplinary analysis. Other

Brain research 1975 122 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 150-250 mg/day
cognitivesupport:: 250-500 mg sublingually

上限量： Not established; well-tolerated up to 1,000 mg/day

研究で検討された用量

用量	期間	効果	N
None	--	Mixed	--
None	--	Positive	--
None	--	Mixed	--
None	--	Neutral	--
5 mg/kg	4 weeks	Positive	--
1 g	--	Mixed	--
None	--	Mixed	--
None	--	Mixed	--

推奨摂取タイミング： Morning; synergizes with DHA and choline sources

Safety & Side Effects

報告されている副作用

⚠ Mild gastrointestinal discomfort
⚠ Headache (rare)
⚠ Nervousness at high doses

既知の相互作用

● No significant drug interactions established

耐容上限摂取量： Not established; well-tolerated up to 1,000 mg/day

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Uridine Monophosphate help with Neurotransmitter Imbalance?

Based on 4 studies with 300 participants, there is limited but promising evidence that Uridine Monophosphate may support Neurotransmitter Imbalance management. Our evidence grade is C (Some Evidence).

How much Uridine Monophosphate should I take for Neurotransmitter Imbalance?

Studies have used various dosages. A commonly studied range is 150-250 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Uridine Monophosphate?

Reported side effects may include Mild gastrointestinal discomfort, Headache (rare), Nervousness at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Uridine Monophosphate and Neurotransmitter Imbalance?

We rate the evidence as Grade C (Some Evidence). This rating is based on 4 peer-reviewed studies with 300 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Neurotransmitter Imbalance

Alpha-GPC B Zinc C

総合評価

Evidence Strength52%

Moderate confidence

研究の内訳

RCT (1)Meta (0)Other (3)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Neurotransmitter Imbalance

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FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。