What is the recommended dosage for N-Acetyl Cysteine?

General: 600-1,800 mg/day; Neuroprotection: 1,200-2,400 mg/day

What are the side effects of N-Acetyl Cysteine?

Potential side effects include: Nausea and vomiting, Diarrhea, Unpleasant sulfur taste/smell, Rare: bronchospasm (inhaled form), Long-term use may deplete zinc stores.

What is N-Acetyl Cysteine?

N-Acetyl Cysteine (NAC) is a supplemental form of the amino acid cysteine and a precursor to glutathione, the body's primary intracellular antioxidant. Research has explored its potential role in reducing oxidative stress in brain tissue and supporting neurotransmitter balance, particularly glutamate regulation.

What dosage of NAC has been used in brain health studies?

Clinical studies for neurological and cognitive outcomes have typically used 600 mg to 2,400 mg of NAC daily, often divided into two doses. A common starting dose is 600 mg twice daily. Consult your healthcare provider for personalized recommendations.

What are the potential side effects of NAC?

NAC may cause nausea, vomiting, diarrhea, and stomach discomfort. It has a sulfurous taste and smell. NAC may interact with nitroglycerin and blood-thinning medications. People with asthma should use caution as inhaled NAC may cause bronchospasm. Consult your healthcare provider.

N-Acetyl Cysteine
N-Acetyl Cysteine

amino_acid

別名: NAC, N-Acetylcysteine, Acetylcysteine

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About

NAC is a precursor to glutathione, the brain's primary endogenous antioxidant. It modulates glutamate neurotransmission and has demonstrated neuroprotective effects in brain injury models, with MRI studies showing improvements in brain connectivity.

How It Works

Precursor to glutathione, the brain's primary endogenous antioxidant; modulates glutamate neurotransmission; reduces neuroinflammation and oxidative stress.

Evidence For Conditions

症状・状態	グレード	研究数	参加者数
Oxidative Stress & Neuroinflammation	B	12	800	詳細を見る →
Post-Concussion Cognitive Symptoms	B	6	400	詳細を見る →
Depression-Related Cognitive Dysfunction	C	6	400	詳細を見る →

Side Effects

Nausea and vomiting
Diarrhea
Unpleasant sulfur taste/smell
Rare: bronchospasm (inhaled form)
Long-term use may deplete zinc stores

Drug & Supplement Interactions

Nitroglycerin (may enhance hypotensive effects)
Activated charcoal (reduces NAC absorption)
Anticoagulants (theoretical interaction)

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Related Ingredients

L-Theanine Taurine Acetyl-L-Carnitine

基本情報

用量: General: 600-1,800 mg/day; Neuroprotection: 1,200-2,400 mg/day
剤形: capsule tablet powder effervescent
天然の供給源: Not found in food; synthesized from L-cysteine (found in poultry, garlic, onions)
上限量: Not established as supplement; 6,000+ mg/day used clinically (IV)
推奨摂取タイミング: On empty stomach; split into 2-3 doses; supplement zinc if using long-term

エビデンスの要約

Oxidative Stress & Neuroinflammation B

Post-Concussion Cognitive Symptoms B

Depression-Related Cognitive Dysfunction C

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