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Melatonin para Sleep-Related Cognitive Impairment

C

Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.

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C

Conclusão

Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.

Key Study Findings

review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) vs: Placebo Efeito: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence None
Other
Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin …
Dose: None vs: PCPA-induced insomnia model control Outcome: Sleep quality and cognitive function in rat model Efeito: None None

População: PCPA-induced insomnia male rats

Randomized Controlled Trial n=322 5 weeks Double-blind
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, …
Dose: 20 mg or 50 mg tasimelteon daily vs: Placebo Outcome: Latency to persistent sleep (PSG) Efeito: -44.9 min (20mg) / -46.3 min (50mg) vs -28.2 (placebo) <0.001

População: Patients with primary insomnia (sleep onset difficulty)

Review
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Dose: None vs: None Outcome: ISWRD symptom management Efeito: None None

População: Patients with irregular sleep-wake rhythm disorder

review
Insomnia in older adults: A review of treatment options.
Dose: various vs: Placebo Efeito: None None
Review
Commonly encountered symptoms and their management in patients with cirrhosis.
Dose: None vs: None Outcome: Pain outcomes Efeito: None None

População: Insomnia patients

Key Statistics

15

Estudos

2000

Participantes

Positive

C

Nota

Referenced Papers

Pediatrics in review 2026
Cleveland Clinic journal … 2025 12 citações
Current opinion in … 2024 12 citações
La Revue du … 2024
Progress in neuro-psychopharmacology … 2021 68 citações
Neurotherapeutics : the … 2020 80 citações
Current treatment options … 2020 29 citações
Human brain mapping 2020 15 citações
Dermatitis : contact, … 2019 7 citações
Journal of sleep … 2017 1691 citações
Neurological research 2017 331 citações
Nutrients 2017 301 citações
Current treatment options … 2017 56 citações
Clinical therapeutics 2016 328 citações
Chest 2016 109 citações
European heart journal. … 2016 77 citações
Diabetes, obesity & … 2015 132 citações
Alcohol (Fayetteville, N.Y.) 2015 122 citações
Pharmacological reports : … 2011 99 citações
Tidsskrift for den … 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosagens Comumente Utilizadas

general:
0.5-5 mg/day
sleepcognitivesupport:
0.5-3 mg 30-60 min before bed

Limite superior: 10 mg/day (higher doses not more effective)

Dosagens Estudadas em Pesquisas

Dosagem Duração Efeito N
Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) -- Positive --
None -- Positive --
20 mg or 50 mg tasimelteon daily 5 weeks Positive 322
None -- Mixed --
various -- Positive --
None -- Neutral --
None -- Positive 6528
Z-drugs, melatonin, orexin antagonists -- Positive --

Melhor horário: 30-60 minutes before bedtime

Safety & Side Effects

Efeitos Colaterais Relatados

  • Daytime drowsiness
  • Headache
  • Dizziness
  • Nausea
  • Vivid dreams

Interações Conhecidas

  • Sedative medications (additive drowsiness)
  • Blood thinners (may increase bleeding risk)
  • Diabetes medications (may affect blood sugar)
  • Immunosuppressants (may stimulate immune function)
  • Oral contraceptives (may increase melatonin levels)

Ingestão máxima tolerável: 10 mg/day (higher doses not more effective)

Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.

Frequently Asked Questions

Does Melatonin help with Sleep-Related Cognitive Impairment?
Based on 15 studies with 2,000 participants, there is limited but promising evidence that Melatonin may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
How much Melatonin should I take for Sleep-Related Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 0.5-5 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Sleep-Related Cognitive Impairment?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Outros ingredientes para Sleep-Related Cognitive Impairment

Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.