Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease.

Madhuri Venigalla, Erika Gyengesi, Gerald Münch

Review Neural regeneration research 2015 161 citações

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Study Design

Tipo de Estudo: Review
População: Alzheimer's disease patients

Intervenção: Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease. None
Comparador: None
Desfecho Primário: None
Direção do Efeito: Positive
Risco de Viés: Unclear

Abstract

Alzheimer's disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Current treatments for Alzheimer's disease primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for Alzheimer's disease patients. This review will provide an overview of the proven antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of curcumin and apigenin and discuss the potential of these compounds for Alzheimer's disease prevention and treatment. We suggest that these compounds might delay the onset of Alzheimer's disease or slow down its progression, and they should enter clinical trials as soon as possible.

Resumo Rápido

It is suggested that curcumin and apigenin might delay the onset of Alzheimer′s disease or slow down its progression, and they should enter clinical trials as soon as possible.

Used In Evidence Reviews

B Curcumin para Oxidative Stress & Neuroinflammation

Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease.

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Study Design

Abstract

Resumo Rápido

Used In Evidence Reviews

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