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Melatonin для Sleep-Related Cognitive Impairment

C

Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.

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C

Итог

Well-established for sleep optimization, melatonin may support cognitive function indirectly by promoting glymphatic clearance of beta-amyloid and other metabolic waste during sleep.

Key Study Findings

review
Pediatric Insomnia.
Dose: Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) или: Placebo Эффект: CBT-I most effective treatment; melatonin beneficial in children with ASD or ADHD; limited evidence None
Other
Banxia Shumi Decoction Improves Sleep and Neural Function in Insomnia Male Rats via BDNF/TrkB/CREB-Dependent Melatonin …
Dose: None или: PCPA-induced insomnia model control Outcome: Sleep quality and cognitive function in rat model Эффект: None None

Популяция: PCPA-induced insomnia male rats

Randomized Controlled Trial n=322 5 weeks Double-blind
Melatonin agonist tasimelteon (HETLIOZ®) improves sleep in patients with primary insomnia: A multicenter, randomized, double-blind, …
Dose: 20 mg or 50 mg tasimelteon daily или: Placebo Outcome: Latency to persistent sleep (PSG) Эффект: -44.9 min (20mg) / -46.3 min (50mg) vs -28.2 (placebo) <0.001

Популяция: Patients with primary insomnia (sleep onset difficulty)

Review
Irregular sleep-wake rhythm disorder: From the pathophysiologic perspective to the treatment.
Dose: None или: None Outcome: ISWRD symptom management Эффект: None None

Популяция: Patients with irregular sleep-wake rhythm disorder

review
Insomnia in older adults: A review of treatment options.
Dose: various или: Placebo Эффект: None None
Review
Commonly encountered symptoms and their management in patients with cirrhosis.
Dose: None или: None Outcome: Pain outcomes Эффект: None None

Популяция: Insomnia patients

Key Statistics

15

Исследования

2000

Участники

Positive

C

Оценка

Referenced Papers

Pediatrics in review 2026
Cleveland Clinic journal … 2025 12 цитирований
Current opinion in … 2024 12 цитирований
Frontiers in medicine 2024 4 цитирований
La Revue du … 2024
Journal of sleep … 2023 12 цитирований
Frontiers in neuroscience 2023 5 цитирований
Current drug safety 2023 2 цитирований
Progress in neuro-psychopharmacology … 2021 68 цитирований
Climacteric : the … 2020 97 цитирований
Neurotherapeutics : the … 2020 80 цитирований
Current treatment options … 2020 29 цитирований
Human brain mapping 2020 15 цитирований
Dermatitis : contact, … 2019 7 цитирований
Journal of sleep … 2017 1691 цитирований
Neurological research 2017 331 цитирований
Nutrients 2017 301 цитирований
Current treatment options … 2017 56 цитирований
Clinical therapeutics 2016 328 цитирований
Chest 2016 109 цитирований
European heart journal. … 2016 77 цитирований
Diabetes, obesity & … 2015 132 цитирований
Alcohol (Fayetteville, N.Y.) 2015 122 цитирований
Menopause (New York, … 2015 73 цитирований
Chest 2013 53 цитирований
Pharmacological reports : … 2011 99 цитирований
Progress in neuro-psychopharmacology … 2011 71 цитирований
Der Nervenarzt 2009 6 цитирований
Pharmacotherapy 2007 117 цитирований
Tidsskrift for den … 2006
Brain research. Molecular … 2005 160 цитирований
Reviews of reproduction 1998 381 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
0.5-5 mg/day
sleepcognitivesupport:
0.5-3 mg 30-60 min before bed

Верхний предел: 10 mg/day (higher doses not more effective)

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
Melatonin (various doses), CBT-I (behavioral), pharmacologic options (z-drugs, other) -- Positive --
None -- Positive --
20 mg or 50 mg tasimelteon daily 5 weeks Positive 322
None -- Mixed --
various -- Positive --
None -- Neutral --
None -- Positive 6528
Z-drugs, melatonin, orexin antagonists -- Positive --

Лучшее время приёма: 30-60 minutes before bedtime

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Daytime drowsiness
  • Headache
  • Dizziness
  • Nausea
  • Vivid dreams

Известные взаимодействия

  • Sedative medications (additive drowsiness)
  • Blood thinners (may increase bleeding risk)
  • Diabetes medications (may affect blood sugar)
  • Immunosuppressants (may stimulate immune function)
  • Oral contraceptives (may increase melatonin levels)

Допустимый верхний уровень потребления: 10 mg/day (higher doses not more effective)

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Melatonin help with Sleep-Related Cognitive Impairment?
Based on 15 studies with 2,000 participants, there is limited but promising evidence that Melatonin may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).
How much Melatonin should I take for Sleep-Related Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 0.5-5 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Melatonin?
Reported side effects may include Daytime drowsiness, Headache, Dizziness, Nausea. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Melatonin and Sleep-Related Cognitive Impairment?
We rate the evidence as Grade C (Some Evidence). This rating is based on 15 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Sleep-Related Cognitive Impairment

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