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Creatine biosynthesis from arginine, glycine, and methionine is outlined, illustrating the metabolic pathway of this endogenous compound stored primarily in skeletal muscle.

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![Figure 1: Creatine biosynthesis from arginine, glycine, and methionine is outlined, illustrating the metabolic pathway of this endogenous compound stored primarily in skeletal muscle.]()

> Source: Rachel N Smith et al. "A review of creatine supplementation in age-related diseases: more than a supple." *F1000Research*, 2014. PMID: [25664170](https://pubmed.ncbi.nlm.nih.gov/25664170/)
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  <img src="" alt="Creatine biosynthesis from arginine, glycine, and methionine is outlined, illustrating the metabolic pathway of this endogenous compound stored primarily in skeletal muscle." />
  <figcaption>Figure 1. Creatine biosynthesis from arginine, glycine, and methionine is outlined, illustrating the metabolic pathway of this endogenous compound stored primarily in skeletal muscle.<br>  Source: Rachel N Smith et al. "A review of creatine supplementation in age-related diseases: more than a supple." <em>F1000Research</em>, 2014. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/25664170/">25664170</a></figcaption>
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