Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.

Airi Watanabe, Nobumasa Kato, Tadafumi Kato

Other Neuroscience research 2002 180 atıf

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Study Design

Çalışma Türü: Controlled Clinical Trial
Örneklem Büyüklüğü: 24
Popülasyon: Healthy adults

Müdahale: Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation. Creatine 8g/day for 5 days
Karşılaştırıcı: Placebo
Birincil Sonuç: Mental fatigue and cerebral hemoglobin oxygenation
Etki Yönü: Positive
Yanlılık Riski: Moderate

Abstract

While the role of creatine in preventing muscle (peripheral) fatigue for high performance athletes is well understood, its biochemical role in prevention of mental (central) fatigue is not. Creatine is abundant in muscles and the brain and after phosphorylation used as an energy source for adenosine triphosphate synthesis. Using double-blind placebo-controlled paradigm, we demonstrated that dietary supplement of creatine (8 g/day for 5 days) reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation. After taking the creatine supplement, task-evoked increase of cerebral oxygenated hemoglobin in the brains of subjects measured by near infrared spectroscopy was significantly reduced, which is compatible with increased oxygen utilization in the brain.

Kısaca

Using double-blind placebo-controlled paradigm, it is demonstrated that dietary supplement of creatine reduces mental fatigue when subjects repeatedly perform a simple mathematical calculation.

Used In Evidence Reviews

B Creatine için Mental Fatigue

Effects of creatine on mental fatigue and cerebral hemoglobin oxygenation.

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Study Design

Abstract

Kısaca

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