Vitamin E 用于 Age-Related Cognitive Decline
CHigh-dose vitamin E may slow functional decline in moderate Alzheimer's disease (TEAM-AD trial). Results are mixed for cognitive decline prevention in healthy populations.
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C
结论
High-dose vitamin E may slow functional decline in moderate Alzheimer's disease (TEAM-AD trial). Results are mixed for cognitive decline prevention in healthy populations.
Key Study Findings
Systematic Review
n=80488
Vitamin E and cognitive function: A systematic review of clinical evidence.
Dose: None
vs: None
Outcome: cognitive function / cognitive impairment
效果: None
None
研究人群: participants from 43 clinical studies (2012-2022)
Review
Exploring the Efficacy and Safety of Nutritional Supplements in Alzheimer's Disease.
Dose: Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d
vs: None
Outcome: Cognitive decline in AD
效果: None
None
研究人群: Alzheimer's disease patients
Observational Study
n=2713
Open-label
Non-linear association between dietary fiber intake and cognitive function mediated by vitamin E: a cross-sectional …
Dose: Inflection at 29.65 g/day (DSST), 22.65 g/day (composite)
vs: Cross-sectional fiber intake groups
Outcome: Cognitive function composite z-scores (DSST, AFT, CERAD)
效果: β=0.18 per unit fiber below inflection
<0.0001
研究人群: NHANES adults aged ≥60 years (2011-2014)
Review
The Role of Vitamins in Neurodegeneration: A Brief Review of Mechanisms, Clinical Evidence, and Therapeutic …
Dose: None
vs: None
Outcome: None
效果: None
None
研究人群: Review of vitamins in neurodegeneration
Review
Bioactive compounds and dietary patterns in Alzheimer's disease.
Dose: None
vs: None
Outcome: AD progression and cognitive decline
效果: None
None
研究人群: Elderly with or at risk of Alzheimer's disease (review)
Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None
vs: Standard care or placebo
Outcome: Global cognition in stroke survivors
效果: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins)
0.009 (protein); 0.02 (B-vit)
研究人群: Adult stroke survivors (20 trials + 14 observational)
Key Statistics
12
研究数量
3000
受试者
↔
Mixed
C
等级
Referenced Papers
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The Role of Dietary Antioxidants and Their Potential Mechanisms in Alzheimer's Disease Treatment.
Review
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2022
87 次引用
Vitamin Supplementation and Dementia: A Systematic Review.
Systematic Review
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76 次引用
Medicina (Kaunas, Lithuania)
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26 次引用
Journal of Alzheimer's …
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4 次引用
The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.
Review
Journal of clinical …
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38 次引用
A meta-analysis of peripheral tocopherol levels in age-related cognitive decline and Alzheimer's disease.
Meta-Analysis
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6 次引用
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5 次引用
Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study.
Observational
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2018
159 次引用
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2018
128 次引用
Over-the-Counter Supplement Interventions to Prevent Cognitive Decline, Mild Cognitive Impairment, and Clinical Alzheimer-Type Dementia: A Systematic Review.
Systematic Review
Annals of internal …
2018
119 次引用
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2017
73 次引用
Journal of trace …
2017
24 次引用
Annals of the …
2016
162 次引用
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2016
89 次引用
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62 次引用
Journal of Alzheimer's …
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112 次引用
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2015
100 次引用
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2015
62 次引用
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2015
25 次引用
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2014
118 次引用
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2014
25 次引用
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2013
253 次引用
Plant foods for …
2013
155 次引用
Antioxidant nutrients and age-related cognitive decline: a systematic review of population-based cohort studies.
Systematic Review
European journal of …
2013
61 次引用
Nutrition journal
2013
26 次引用
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158 次引用
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2010
70 次引用
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21 次引用
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2009
139 次引用
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65 次引用
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2009
49 次引用
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38 次引用
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2007
16 次引用
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2002
354 次引用
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191 次引用
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2002
24 次引用
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30 次引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
常用剂量
- general:
- 15 mg/day (RDA)
- cognitivesupport:
- 400-800 IU/day
上限： 1,000 mg/day (1,500 IU natural / 1,100 IU synthetic)
研究中使用的剂量
| 剂量 | 持续时间 | 效果 | N |
|---|---|---|---|
| None | -- | Positive | 80488 |
| Curcumin 800mg/d, omega-3 2g/d, resveratrol 600mg/d | -- | Mixed | -- |
| Inflection at 29.65 g/day (DSST), 22.65 g/day (composite) | -- | Positive | 2713 |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
最佳服用时间： With meals containing fat
Safety & Side Effects
已报告的副作用
- ⚠ Increased bleeding risk at high doses
- ⚠ Nausea and diarrhea
- ⚠ Fatigue and weakness
- ⚠ Blurred vision
已知相互作用
- ● Anticoagulants (increased bleeding risk)
- ● Statins and niacin (may reduce HDL-raising effects)
- ● Chemotherapy and radiation (may reduce efficacy)
可耐受最高摄入量： 1,000 mg/day (1,500 IU natural / 1,100 IU synthetic)
在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
Frequently Asked Questions
Does Vitamin E help with Age-Related Cognitive Decline?
Based on 12 studies with 3,000 participants, there is limited but promising evidence that Vitamin E may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Vitamin E should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 15 mg/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Vitamin E?
Reported side effects may include Increased bleeding risk at high doses, Nausea and diarrhea, Fatigue and weakness, Blurred vision. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Vitamin E and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 12 peer-reviewed studies with 3,000 total participants. The overall direction of effect is mixed.
Related Evidence
其他成分用于 Age-Related Cognitive Decline
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