FolateFolate
vitamin
Folate
Folate
别名: Vitamin B9, Folic Acid, 5-MTHF, Methylfolate, L-Methylfolate
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About
Folate is a critical cofactor in the homocysteine-methionine cycle, supporting SAM production essential for neurotransmitter synthesis and DNA methylation. Combined with B12, folate supplementation slowed brain atrophy rate in MCI patients.
How It Works
Critical cofactor in the homocysteine-methionine cycle; supports SAM production essential for neurotransmitter synthesis and DNA methylation; deficiency leads to elevated homocysteine associated with cerebral damage.
Evidence For Conditions
| 健康状况 | 等级 | 研究数量 | 受试者 | |
|---|---|---|---|---|
| Nutritional Deficiency Cognitive Impairment | B | 10 | 1500 | 查看 → |
Side Effects
- Generally well-tolerated
- May mask B12 deficiency symptoms
- Rare: insomnia or irritability at high doses
Drug & Supplement Interactions
- Methotrexate (antagonist — folate reduces efficacy)
- Anticonvulsants (phenytoin, carbamazepine — mutual interference)
- Sulfasalazine (reduces folate absorption)
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Related Ingredients
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