Ashwagandha für Sleep-Related Cognitive Impairment

Q: Does Ashwagandha help with Sleep-Related Cognitive Impairment?

Based on 6 studies with 500 participants, there is limited but promising evidence that Ashwagandha may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).

Q: How much Ashwagandha should I take for Sleep-Related Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Ashwagandha?

Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Ashwagandha and Sleep-Related Cognitive Impairment?

We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.

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Fazit

Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.

Key Study Findings

Review

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …

Dose: None vs.: None Outcome: None Wirkung: None None

Population: narrative review of ashwagandha clinical trials and basic research (1994-present)

preclinical animal/in vitro study

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …

Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs.: Placebo Wirkung: None None

animal_study

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in …

Dose: 10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden) vs.: Placebo Wirkung: At 50 mg/kg: 34% decrease in sleep onset time (p<0.0001); 47% increase in sleep duration (p<0.0001); <0.0001

In Vitro

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of …

Dose: ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model) vs.: Placebo Wirkung: ASH improved locomotor and cognitive deficits, serum hepatotoxicity indices, oxidative stress marker

Key Statistics

Studien

500

Teilnehmer

↑

Positive

Bewertung

Referenced Papers

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. Review

Nutrients 2026

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … Other

Journal of ethnopharmacology 2025 9 Zitierungen

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … Other

Preventive nutrition and … 2022 18 Zitierungen

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … Other

Journal of ethnopharmacology 2021 69 Zitierungen

Neurodegenerative diseases and Withania somnifera (L.): An update. Review

Journal of ethnopharmacology 2020 85 Zitierungen

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Übliche Dosierungen

general:: 300-600 mg/day of root extract (KSM-66 or Sensoril)
cognitivesupport:: 600 mg/day

Obergrenze: Not established; well-tolerated up to 1,250 mg/day

In der Forschung untersuchte Dosierungen

Dosierung	Dauer	Wirkung	N
None	--	Positive	--
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL	--	Positive	--
10, 25, or 50 mg/kg body weight ashwagandha extract (AE, 35% withanolide glycosides, Shoden)	--	Positive	--
ASH root extract 200 mg/kg and 400 mg/kg for 29 days (rat model)	--	Positive	--

Beste Einnahmezeit: With meals; morning or evening depending on individual response

Safety & Side Effects

Gemeldete Nebenwirkungen

⚠ Drowsiness
⚠ Gastrointestinal discomfort
⚠ Rare: liver injury (with contaminated or high-dose products)
⚠ Thyroid hormone elevation (may affect thyroid medications)

Bekannte Wechselwirkungen

● Thyroid medications (may increase thyroid hormone levels)
● Sedative medications (additive CNS depression)
● Immunosuppressants (may stimulate immune activity)
● Diabetes medications (may lower blood sugar)

Tolerierbare Höchstaufnahmemenge: Not established; well-tolerated up to 1,250 mg/day

Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.

Frequently Asked Questions

Does Ashwagandha help with Sleep-Related Cognitive Impairment?

Based on 6 studies with 500 participants, there is limited but promising evidence that Ashwagandha may support Sleep-Related Cognitive Impairment management. Our evidence grade is C (Some Evidence).

How much Ashwagandha should I take for Sleep-Related Cognitive Impairment?

Studies have used various dosages. A commonly studied range is 300-600 mg/day of root extract (KSM-66 or Sensoril). Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Ashwagandha?

Reported side effects may include Drowsiness, Gastrointestinal discomfort, Rare: liver injury (with contaminated or high-dose products), Thyroid hormone elevation (may affect thyroid medications). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Ashwagandha and Sleep-Related Cognitive Impairment?

We rate the evidence as Grade C (Some Evidence). This rating is based on 6 peer-reviewed studies with 500 total participants. The overall direction of effect is positive.

Related Evidence

Andere Inhaltsstoffe für Sleep-Related Cognitive Impairment

Melatonin C L-Theanine C Magnesium L-Threonate C Creatine C

Ashwagandha für andere Beschwerden

Stress-Induced Cognitive Decline B Anxiety-Related Cognitive Impairment B

Kurzfazit

Research suggests KSM-66 ashwagandha may help improve sleep quality and next-morning cognitive performance in stressed adults through cortisol modulation.

Evidence Strength52%

Moderate confidence

Studienübersicht

RCT (0)Meta (0)Other (6)

Alternativen vergleichen

Sehen Sie, wie andere Inhaltsstoffe bei dieser Beschwerde abschneiden.

Alle Inhaltsstoffe ansehen für Sleep-Related Cognitive Impairment

Mehr erfahren

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