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BrainCited

Forschungsprozess

368 Abbildungen aus begutachteter Forschung

Alle Vitamin E Green Tea Extract (EGCG) Citicoline Folate Zinc Bacopa monnieri Omega-3 Fatty Acids (DHA/EPA) Alpha-Lipoic Acid Creatine Resveratrol Vitamin D L-Theanine Vitamin B12 Ginkgo biloba Lutein & Zeaxanthin Melatonin Rhodiola rosea Panax Ginseng Phosphatidylserine Taurine Curcumin Uridine Monophosphate
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Figure 5
Figure 5

Immunotherapy of Mild Cognitive Impairment by ω-3 Supplementation: Why Are Amyloid-β Antibodies …

Figure 1. Correlations between PLA2 activity and GPs- LOAD demonstrated no significant correlation between PLA2 activity and PC in NP (a). However, PLA2 positively correlated with PC in NP in OD samples (ρ = 0.81, p < 0.03) (b). PLA2 activity in CSF fr
Figure 5 Chart

Correlation analysis between PLA2 activity and glycerophospholipid levels in Alzheimer's disease patients reveals no significant association, suggesting independent dysregulation pathways.

Lipid Metabolism in Late-Onset Alzheimer's Disease Differs from Patients Presenting with Other …

Figure 1. Experimental design. SCS: sodium carboxymethyl cellulose; BE: berberine and evodiamine; FF: fenofibrate.
Figure 5 Flowchart

The experimental design outlines the group allocation including sodium carboxymethyl cellulose control, berberine-evodiamine combination, and fenofibrate positive control arms.

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver …

Figure 6
Figure 6 Chart

Gut microbiota composition analyzed by 16S rRNA sequencing reveals distinct community structures across treatment groups, with the combination therapy restoring microbial diversity.

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver …

Figure 7
Figure 7 Chart

Alpha diversity indices of gut microbiota are compared across groups, indicating that berberine and evodiamine co-administration partially reverses high-fat diet-induced dysbiosis.

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver …

Figure 8
Figure 8 Chart

Key bacterial taxa differentially abundant between treatment groups are identified, with specific genera associated with improved metabolic outcomes in the combination therapy arm.

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver …

Figure 9
Figure 9 Chart

Short-chain fatty acid concentrations in fecal samples reflect changes in microbial metabolic activity following berberine and evodiamine treatment.

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver …

Figure 10
Figure 10 Chart

Correlation analysis between gut microbiota composition and hepatic lipid parameters links specific bacterial taxa to the amelioration of non-alcoholic fatty liver disease.

The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver …

Figure 1. Expression of c‑Fos was evaluated by immunohistochemical staining. Middle‑aged control rats showed lower c‑Fos expression than the adult controls in the mPFC, dentate gyrus, CA3, and CA1 areas. Magnification, x20; scale bar, 50 µm. mPFC, medial
Figure 8

Figure 1. Expression of c‑Fos was evaluated by immunohistochemical staining. Middle‑aged control rats showed lower c‑Fos expression than the adult controls in the mPFC, dentate gyrus, CA3, and CA1 areas. …

Effects of curcumin and γ-oryzanol solid dispersion on the brain of middle-aged …

Figure 9
Figure 9

Effects of curcumin and γ-oryzanol solid dispersion on the brain of middle-aged …

Figure 10
Figure 10

Effects of curcumin and γ-oryzanol solid dispersion on the brain of middle-aged …

Figure 11
Figure 11

Effects of curcumin and γ-oryzanol solid dispersion on the brain of middle-aged …

Figure 12
Figure 12

Effects of curcumin and γ-oryzanol solid dispersion on the brain of middle-aged …

Figure 13
Figure 13

Effects of curcumin and γ-oryzanol solid dispersion on the brain of middle-aged …

Figure 14
Figure 14

Effects of curcumin and γ-oryzanol solid dispersion on the brain of middle-aged …

Figure 8. Effect of GOSD and CURSD on levels of TNF‑α in (A) the prefrontal cortex, and (B) hippocampus areas. Data are presented as the mean ± SEM. TNF‑α, tumor necrosis factor‑α; GOSD, γ‑oryzanol solid dispersion; CURSD, curcumin solid dispersion.
Figure 15

Figure 8. Effect of GOSD and CURSD on levels of TNF‑α in (A) the prefrontal cortex, and (B) hippocampus areas. Data are presented as the mean ± SEM. TNF‑α, tumor …

Effects of curcumin and γ-oryzanol solid dispersion on the brain of middle-aged …

Fig. 2 Orthogonal partial least‑squares discriminant analysis (OPLS‑DA) score plots in CSF samples obtained from (A) comparison between young, middle, and old patients (reliability: R2X= 0.732, R2Y= 0.320, Q2= 0.206). (B) young patients versus old patient
Figure 6 Chart

Scatter plots of individual metabolite abundance versus age reveal significant correlations for specific compounds, suggesting continuous metabolic drift across the lifespan.

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid …

Fig. 3 Scatter plot of log2 transformed metabolite abundance and its correlation with age in metabolites with significant correlation with aging. Value refers to log2 transformed intensity and age is given in years. The colored zones refer to 95% confiden
Figure 7 Chart

Sex-stratified metabolite-age correlation analysis in cerebrospinal fluid shows both shared and sex-specific metabolic aging patterns.

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid …

Fig. 4 Scatter plot of log2 transformed metabolite abundance and its correlation with age within male and female group. Value refers to log2 transformed intensity and age is given in years. The colored zones refer to 95% confidence intervals of the regres
Figure 8 Chart

Pathway enrichment analysis of age-associated CSF metabolites identifies disrupted metabolic pathways, including amino acid and lipid metabolism, during brain aging.

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid …

Figure 9
Figure 9 Chart

Receiver operating characteristic curves evaluate the discriminative ability of selected CSF metabolites to distinguish older from younger cognitively healthy adults.

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid …

Fig. 6 A schematic diagram illustrates these profiled CSF metabolites change during brain aging process. These aging‑related CSF metabolomic change might suggest possible blood‑brain barrier(BBB) breakdown, neuroinflammation, and mitochodrial dysfunction
Figure 10 Diagram

A schematic diagram summarizes the profiled CSF metabolite changes during brain aging, linking age-related metabolic shifts to neurodegeneration risk pathways.

Exploring the aging process of cognitively healthy adults by analyzing cerebrospinal fluid …

Figure 6
Figure 6 Chart

Metabolomics profiling identifies significantly altered metabolites in precocious versus normal crabs, with enrichment in lipid and amino acid metabolic pathways.

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old …

Figure 7
Figure 7 Chart

Principal component analysis of metabolomic data separates precocious from normally developing crabs based on their distinct metabolic profiles.

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old …

Figure 8
Figure 8 Chart

Volcano plot visualization highlights metabolites significantly enriched or depleted in precocious crabs compared to age-matched controls.

Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old …

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