Lion's Mane Mushroom pour Mild Cognitive Impairment (MCI)

Q: Does Lion's Mane Mushroom help with Mild Cognitive Impairment (MCI)?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support Mild Cognitive Impairment (MCI) management. Our evidence grade is B (Good Evidence).

Q: How much Lion's Mane Mushroom should I take for Mild Cognitive Impairment (MCI)?

Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lion's Mane Mushroom?

Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lion's Mane Mushroom and Mild Cognitive Impairment (MCI)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

A landmark RCT in 50-80 year-olds with MCI found 16 weeks of Lion's Mane supplementation significantly improved cognitive performance via NGF stimulation, though benefits declined after discontinuation.

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En conclusion

Key Study Findings

Review

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant …

Dose: None vs: None Outcome: Schizophrenia symptom improvement (theoretical) Effet: None None

Population: Patients with chronic/treatment-resistant schizophrenia

Review

ALSUntangled #73: Lion's Mane.

Dose: Hericium erinaceus (Lion's Mane) vs: None Outcome: Neuroprotection and ALS progression Effet: None None

Population: ALS patients (limited evidence)

Review

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the …

Dose: Hericium erinaceus (Lion's Mane) extracts vs: None Outcome: Neuroprotection and cognitive improvement Effet: None None

Population: Neurodegenerative disease patients (review)

Review

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.

Dose: None vs: None Outcome: None Effet: None None

Population: None

In Vitro

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.

Dose: erinacine A-enriched H. erinaceus mycelium (300mg/kg) vs: untreated transgenic mice Outcome: AD pathology markers and neurogenesis Effet: reduced amyloid plaque, increased neurogenesis <0.05

Population: APPswe/PS1dE9 transgenic AD mice

Randomized Controlled Trial n=30 2.0 weeks Double-blind

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled …

Dose: 250 mg vs: placebo Outcome: cognitive function Effet: None None

Population: dementia patients

Key Statistics

Études

400

Participants

↑

Positive

Note

Referenced Papers

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia. Review

Psychopharmacology bulletin 2025

ALSUntangled #73: Lion's Mane. Other

Amyotrophic lateral sclerosis … 2024 2 citations

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? Review

Journal of fungi … 2023 44 citations

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Review

Journal of clinical … 2021 38 citations

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. Other

Journal of biomedical … 2016 98 citations

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. RCT

Phytotherapy research : … 2009 227 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

general:: 500-3,000 mg/day
cognitivesupport:: 1,000-3,000 mg/day of fruiting body extract

Limite supérieure : Not established; well-tolerated up to 3,000 mg/day

Posologies étudiées dans la recherche

Posologie	Durée	Effet	N
None	--	Positive	--
Hericium erinaceus (Lion's Mane)	--	Neutral	--
Hericium erinaceus (Lion's Mane) extracts	--	Positive	--
None	--	Mixed	--
erinacine A-enriched H. erinaceus mycelium (300mg/kg)	--	Positive	--
250 mg	2.0 weeks	Positive	30

Moment optimal de prise : With meals; effects observed after 8-16 weeks of consistent use

Safety & Side Effects

Effets indésirables signalés

⚠ Mild gastrointestinal discomfort
⚠ Skin rash in rare cases (especially with allergies to mushrooms)
⚠ Potential itching or tingling sensations

Interactions connues

● Anticoagulants (may have mild antiplatelet effects)
● Antidiabetic medications (may lower blood sugar)
● Immunosuppressants (may modulate immune function)

Apport maximal tolérable : Not established; well-tolerated up to 3,000 mg/day

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does Lion's Mane Mushroom help with Mild Cognitive Impairment (MCI)?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support Mild Cognitive Impairment (MCI) management. Our evidence grade is B (Good Evidence).

How much Lion's Mane Mushroom should I take for Mild Cognitive Impairment (MCI)?

Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lion's Mane Mushroom?

Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lion's Mane Mushroom and Mild Cognitive Impairment (MCI)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Autres ingrédients pour Mild Cognitive Impairment (MCI)

Omega-3 Fatty Acids (DHA/EPA) B

Lion's Mane Mushroom pour d'autres pathologies

Memory Loss C Brain Fog C

Verdict rapide

Evidence Strength72%

High confidence

Synthèse des études

RCT (1)Meta (0)Other (5)

Comparer les alternatives

Découvrez comment d'autres ingrédients se comparent pour cette condition.Découvrez comment d'autres ingrédients se comparent pour cette pathologie.

Voir tous les ingrédients pour Mild Cognitive Impairment (MCI)

En savoir plus

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.