Lion's Mane Mushroom untuk Mild Cognitive Impairment (MCI)

Q: Does Lion's Mane Mushroom help with Mild Cognitive Impairment (MCI)?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support Mild Cognitive Impairment (MCI) management. Our evidence grade is B (Good Evidence).

Q: How much Lion's Mane Mushroom should I take for Mild Cognitive Impairment (MCI)?

Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Lion's Mane Mushroom?

Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Lion's Mane Mushroom and Mild Cognitive Impairment (MCI)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

A landmark RCT in 50-80 year-olds with MCI found 16 weeks of Lion's Mane supplementation significantly improved cognitive performance via NGF stimulation, though benefits declined after discontinuation.

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Kesimpulan

Key Study Findings

Review

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant …

Dose: None vs: None Outcome: Schizophrenia symptom improvement (theoretical) Efek: None None

Populasi: Patients with chronic/treatment-resistant schizophrenia

Review

ALSUntangled #73: Lion's Mane.

Dose: Hericium erinaceus (Lion's Mane) vs: None Outcome: Neuroprotection and ALS progression Efek: None None

Populasi: ALS patients (limited evidence)

Review

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the …

Dose: Hericium erinaceus (Lion's Mane) extracts vs: None Outcome: Neuroprotection and cognitive improvement Efek: None None

Populasi: Neurodegenerative disease patients (review)

Review

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.

Dose: None vs: None Outcome: None Efek: None None

Populasi: None

In Vitro

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice.

Dose: erinacine A-enriched H. erinaceus mycelium (300mg/kg) vs: untreated transgenic mice Outcome: AD pathology markers and neurogenesis Efek: reduced amyloid plaque, increased neurogenesis <0.05

Populasi: APPswe/PS1dE9 transgenic AD mice

Randomized Controlled Trial n=30 2.0 weeks Double-blind

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled …

Dose: 250 mg vs: placebo Outcome: cognitive function Efek: None None

Populasi: dementia patients

Key Statistics

Studi

400

Peserta

↑

Positive

Peringkat

Referenced Papers

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia. Review

Psychopharmacology bulletin 2025

ALSUntangled #73: Lion's Mane. Other

Amyotrophic lateral sclerosis … 2024 2 sitasi

Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? Review

Journal of fungi … 2023 44 sitasi

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Review

Journal of clinical … 2021 38 sitasi

Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice. Other

Journal of biomedical … 2016 98 sitasi

Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. RCT

Phytotherapy research : … 2009 227 sitasi

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 500-3,000 mg/day
cognitivesupport:: 1,000-3,000 mg/day of fruiting body extract

Batas atas: Not established; well-tolerated up to 3,000 mg/day

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	--
Hericium erinaceus (Lion's Mane)	--	Neutral	--
Hericium erinaceus (Lion's Mane) extracts	--	Positive	--
None	--	Mixed	--
erinacine A-enriched H. erinaceus mycelium (300mg/kg)	--	Positive	--
250 mg	2.0 weeks	Positive	30

Waktu terbaik diminum: With meals; effects observed after 8-16 weeks of consistent use

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Mild gastrointestinal discomfort
⚠ Skin rash in rare cases (especially with allergies to mushrooms)
⚠ Potential itching or tingling sensations

Interaksi yang Diketahui

● Anticoagulants (may have mild antiplatelet effects)
● Antidiabetic medications (may lower blood sugar)
● Immunosuppressants (may modulate immune function)

Asupan atas yang dapat ditoleransi: Not established; well-tolerated up to 3,000 mg/day

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Lion's Mane Mushroom help with Mild Cognitive Impairment (MCI)?

Based on 6 studies with 400 participants, there is moderate evidence from clinical studies that Lion's Mane Mushroom may support Mild Cognitive Impairment (MCI) management. Our evidence grade is B (Good Evidence).

How much Lion's Mane Mushroom should I take for Mild Cognitive Impairment (MCI)?

Studies have used various dosages. A commonly studied range is 500-3,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Lion's Mane Mushroom?

Reported side effects may include Mild gastrointestinal discomfort, Skin rash in rare cases (especially with allergies to mushrooms), Potential itching or tingling sensations. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Lion's Mane Mushroom and Mild Cognitive Impairment (MCI)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 6 peer-reviewed studies with 400 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Mild Cognitive Impairment (MCI)

Omega-3 Fatty Acids (DHA/EPA) B

Lion's Mane Mushroom untuk kondisi lain

Memory Loss C Brain Fog C

Kesimpulan Singkat

Evidence Strength72%

High confidence

Rincian Studi

RCT (1)Meta (0)Other (5)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Mild Cognitive Impairment (MCI)

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.