Vitamin D untuk Depression-Related Cognitive Dysfunction

Q: Does Vitamin D help with Depression-Related Cognitive Dysfunction?

Based on 12 studies with 2,000 participants, there is limited but promising evidence that Vitamin D may support Depression-Related Cognitive Dysfunction management. Our evidence grade is C (Some Evidence).

Q: How much Vitamin D should I take for Depression-Related Cognitive Dysfunction?

Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Vitamin D and Depression-Related Cognitive Dysfunction?

We rate the evidence as Grade C (Some Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.

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Kesimpulan

Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.

Key Study Findings

Observational Study n=2582

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …

Dose: None vs: None Outcome: Cognitive impairment risk Efek: OR=0.695 (Vit D); OR=0.777 (FA) p=0.003 (Vit D); p=0.034 (FA)

Populasi: Elderly participants aged 60+ from NHANES 2011-2014

Review

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.

Dose: None vs: None Outcome: Pregnancy outcomes and offspring neurodevelopment Efek: None None

Populasi: Pregnant women (review)

Meta-Analysis

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild …

Dose: None vs: Control Outcome: Cognitive function Efek: SMD = 0.58, 95% CI = [0.20, 0.96] P = 0.003

Populasi: Patients with mild cognitive impairment

Other

Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis.

Dose: 75 mg vs: None Outcome: Body weight Efek: None P < 0.05

Populasi: Rat model

Controlled Clinical Trial

Targeting neuroendocrine abnormalities in Parkinson's disease with exercise.

Dose: None vs: None Outcome: neuroprotection Efek: None None

Populasi: None

RCT n=65 36 weeks Double-blind

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: …

Dose: 4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi vs: Placebo Efek: significant improvement in cognitive fatigue (FIS-40); p = 0.0338 0.0338

Key Statistics

Studi

2000

Peserta

↑

Positive

Peringkat

Referenced Papers

Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the NHANES Database. Other

Brain and behavior 2026

B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges. Review

The Proceedings of … 2025 5 sitasi

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … Meta-Analysis

European journal of … 2024 16 sitasi

Dietary Clostridium butyricum and 25-Hydroxyvitamin D3 modulate bone metabolism of broilers through the gut-brain axis. Other

Poultry science 2024 9 sitasi

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. RCT

Nutrients 2023 9 sitasi

Targeting neuroendocrine abnormalities in Parkinson's disease with exercise. Other

Frontiers in neuroscience 2023 5 sitasi

Serum brain-derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case-control … Other

Journal of cosmetic … 2023 3 sitasi

The relationship between neuropsychological function and responsiveness to vitamin D supplementation using artificial neural networks. Other

Nutrition and health 2020 4 sitasi

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life. Meta-Analysis

The Cochrane database … 2018 123 sitasi

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. Review

The journal of … 2017 75 sitasi

Effect of Vitamin Intake on Cognitive Decline in Older Adults: Evaluation of the Evidence. Review

The journal of … 2015 25 sitasi

[Vitamins and nutritional supplements in older persons: How to diagnose and when to substitute?]. Review

Der Internist 2015 3 sitasi

Influence of mineral and vitamin supplements on pregnancy outcome. Review

European journal of … 2012 225 sitasi

Multivitamin/mineral supplements and prevention of chronic disease. Review

Evidence report/technology assessment 2006

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosis yang Umum Digunakan

general:: 600-2,000 IU/day
deficiencycorrection:: 4,000-5,000 IU/day

Batas atas: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)

Dosis yang Diteliti dalam Penelitian

Dosis	Durasi	Efek	N
None	--	Positive	2582
None	--	Positive	--
None	--	Positive	--
75 mg	--	Neutral	--
None	--	Positive	--
4 capsules daily, each containing: beta-glucan 250 mg + vitamin D3 3.75 µg + vitamin B6 1.05 mg + zi	36 weeks	Positive	65
None	--	Negative	90
50000 IU/week	9 weeks	Positive	619

Waktu terbaik diminum: With meals containing fat; morning preferred

Safety & Side Effects

Efek Samping yang Dilaporkan

⚠ Hypercalcemia at very high doses
⚠ Nausea and vomiting
⚠ Kidney stones (rare, high doses)
⚠ Weakness and fatigue

Interaksi yang Diketahui

● Corticosteroids (reduce calcium absorption)
● Statins (both affect cholesterol pathways)
● Thiazide diuretics (additive calcium retention)
● Weight loss drugs (may reduce vitamin D absorption)

Asupan atas yang dapat ditoleransi: 4,000 IU/day (IOM); 10,000 IU/day (Endocrine Society upper safety)

Selalu konsultasikan dengan tenaga kesehatan Anda sebelum memulai suplemen apa pun.Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai suplemen apa pun.

Frequently Asked Questions

Does Vitamin D help with Depression-Related Cognitive Dysfunction?

Based on 12 studies with 2,000 participants, there is limited but promising evidence that Vitamin D may support Depression-Related Cognitive Dysfunction management. Our evidence grade is C (Some Evidence).

How much Vitamin D should I take for Depression-Related Cognitive Dysfunction?

Studies have used various dosages. A commonly studied range is 600-2,000 IU/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Vitamin D?

Reported side effects may include Hypercalcemia at very high doses, Nausea and vomiting, Kidney stones (rare, high doses), Weakness and fatigue. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Vitamin D and Depression-Related Cognitive Dysfunction?

We rate the evidence as Grade C (Some Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

Bahan lain untuk Depression-Related Cognitive Dysfunction

Omega-3 Fatty Acids (DHA/EPA) B N-Acetyl Cysteine C

Vitamin D untuk kondisi lain

Nutritional Deficiency Cognitive Impairment B

Kesimpulan Singkat

Research suggests vitamin D supplementation may help improve depressive symptoms including brain fog and mood-related cognitive symptoms, particularly in deficient individuals.

Evidence Strength52%

Moderate confidence

Rincian Studi

RCT (1)Meta (2)Other (9)

Bandingkan Alternatif

Lihat bagaimana bahan lain dibandingkan untuk kondisi ini.

Lihat semua bahan untuk Depression-Related Cognitive Dysfunction

Pelajari Lebih Lanjut

Penafian FDA: Pernyataan-pernyataan ini belum dievaluasi oleh Food and Drug Administration. Produk dan informasi di situs web ini tidak dimaksudkan untuk mendiagnosis, mengobati, menyembuhkan, atau mencegah penyakit apa pun. Peringkat bukti yang disajikan didasarkan pada analisis kami terhadap penelitian yang ditinjau sejawat dan tidak merupakan saran medis. Selalu konsultasikan dengan penyedia layanan kesehatan Anda sebelum memulai regimen suplemen apa pun.