Folate ： Nutritional Deficiency Cognitive Impairment
BCritical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).
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B
結論
Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).
Key Study Findings
Observational Study
n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None
vs: None
Outcome: Cognitive impairment risk
効果: OR=0.695 (Vit D); OR=0.777 (FA)
p=0.003 (Vit D); p=0.034 (FA)
対象集団: Elderly participants aged 60+ from NHANES 2011-2014
Cross-Sectional Study
n=1966
Folate mediates cognitive impairment of aged people with periodontitis.
Dose: None
vs: Placebo
効果: Mediation proportion: dietary supplement folate 8.4%; serum total folate 9.1%; RBC folate 9.1%
None
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None
vs: None
Outcome: Pregnancy outcomes and offspring neurodevelopment
効果: None
None
対象集団: Pregnant women (review)
Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None
vs: Standard care or placebo
Outcome: Global cognition in stroke survivors
効果: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins)
0.009 (protein); 0.02 (B-vit)
対象集団: Adult stroke survivors (20 trials + 14 observational)
Other
Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.
Dose: None
vs: None
Outcome: Causal association of micronutrients with RLS
効果: Retinol OR 0.46; Mg OR 0.62
None
対象集団: European ancestry (7248 RLS cases, 19802 controls)
Randomized Controlled Trial
Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented)
vs: Within-trial comparison
Outcome: B12/homocysteine association with PD outcomes
効果: None
None
対象集団: Early Parkinson's disease patients
Key Statistics
10
研究数
1500
参加者数
↑
Positive
B
グレード
Referenced Papers
Brain and behavior
2026
The Proceedings of …
2025
5 件の引用
Nutritional neuroscience
2025
1 件の引用
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Meta-Analysis
Advances in nutrition …
2025
1 件の引用
Food science & …
2025
Food and nutrition …
2024
19 件の引用
European journal of …
2024
16 件の引用
Journal of Parkinson's …
2024
1 件の引用
Nutrients
2023
9 件の引用
Clinical nutrition ESPEN
2023
5 件の引用
The British journal …
2022
7 件の引用
The Permanente journal
2022
Nutrition and health
2021
13 件の引用
The Senior care …
2021
2 件の引用
Systematic reviews
2020
29 件の引用
Journal of Alzheimer's …
2018
281 件の引用
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life.
Meta-Analysis
The Cochrane database …
2018
123 件の引用
The journal of …
2017
75 件の引用
Nutrients
2016
114 件の引用
The journal of …
2015
25 件の引用
Ginekologia polska
2015
7 件の引用
Ontario health technology …
2013
European journal of …
2012
225 件の引用
Vitamin B6, B12, and folic acid supplementation and cognitive function: a systematic review of randomized trials.
Systematic Review
Archives of internal …
2007
222 件の引用
Evidence report/technology assessment
2006
Folic acid with or without vitamin B12 for cognition and dementia.
Systematic Review
The Cochrane database …
2003
263 件の引用
Current opinion in …
1998
30 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 400 mcg DFE/day (RDA)
- cognitivesupport:
- 400-800 mcg/day
上限量： 1,000 mcg/day from supplements (may mask B12 deficiency)
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| None | -- | Positive | 2582 |
| None | -- | Positive | 1966 |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Mixed | -- |
| Vitamin B12 (measured, not supplemented) | -- | Positive | -- |
| None | -- | Positive | -- |
| >5 mg/day | -- | Negative | -- |
推奨摂取タイミング： With or without food; morning preferred
Safety & Side Effects
報告されている副作用
- ⚠ Generally well-tolerated
- ⚠ May mask B12 deficiency symptoms
- ⚠ Rare: insomnia or irritability at high doses
既知の相互作用
- ● Methotrexate (antagonist — folate reduces efficacy)
- ● Anticonvulsants (phenytoin, carbamazepine — mutual interference)
- ● Sulfasalazine (reduces folate absorption)
耐容上限摂取量： 1,000 mcg/day from supplements (may mask B12 deficiency)
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Folate help with Nutritional Deficiency Cognitive Impairment?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Folate may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).
How much Folate should I take for Nutritional Deficiency Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate?
Reported side effects may include Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate and Nutritional Deficiency Cognitive Impairment?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Nutritional Deficiency Cognitive Impairment
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