Lutein & Zeaxanthin ： Age-Related Cognitive Decline
C エビデンス 小規模研究からのエビデンスは限られていますが、いくつかの肯定的なシグナルがあります。A 6-month RCT showed macular xanthophylls increased serum BDNF, reduced IL-1beta, and improved composite memory, psychomotor speed, and sustained attention. Macular pigment optical density correlates with cognitive performance.
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C
結論
A 6-month RCT showed macular xanthophylls increased serum BDNF, reduced IL-1beta, and improved composite memory, psychomotor speed, and sustained attention. Macular pigment optical density correlates with cognitive performance.
Key Study Findings
Cohort Study
n=1550
270 weeks
Low Intake of Total Antioxidant Nutrients as a Risk Factor for Incident Dementia in Older …
Dose: >=112 mg/day vs <112 mg/day
vs: Low AN intake (<112 mg/day)
Outcome: Incident dementia
効果: HR 1.87 (95% CI 1.26-2.77)
None
対象集団: Community residents without dementia aged >=60 years
In Vitro
Construction and In Vitro Evaluation of Brain-Targeted Lutein Liposomes.
Dose: None
vs: Free lutein
Outcome: BBB permeability and lutein stability
効果: 22.73% BBB permeability at 12h
None
対象集団: In vitro BBB model and stability tests
Review
Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: systematic review of carotenoids for antiaging (nutraceutical, pharmaceutical, cosmeceutical)
Observational Study
n=72
Association of Habitual Diet Quality and Nutrient Intake with Cognitive Performance in Community-Dwelling Older Adults: …
Dose: None
vs: None
Outcome: Cognitive performance (CERAD battery)
効果: None
0.007 (fiber), 0.004 (K)
対象集団: Community-dwelling older adults aged 65+
Review
Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer's Disease.
Dose: None
vs: None
Outcome: None
効果: None
None
対象集団: None
Observational Study
n=60
Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive …
Dose: None
vs: None
Outcome: Carotenoid moderation of cfPWV-cognition relationship
効果: Beta=0.53, p=0.04 for lutein moderation
0.02
対象集団: Adults, mean age 38.6, 70% female
Key Statistics
8
研究数
600
参加者数
↑
Positive
C
グレード
Referenced Papers
Pharmaceuticals (Basel, Switzerland)
2025
28 件の引用
The American journal …
2025
2 件の引用
Neuroepidemiology
2025
1 件の引用
Foods (Basel, Switzerland)
2025
1 件の引用
The Journal of …
2025
Molecules (Basel, Switzerland)
2025
Nutrients
2025
International journal of …
2024
11 件の引用
International journal of …
2024
4 件の引用
Nutricion hospitalaria
2024
4 件の引用
Journal of Alzheimer's …
2024
1 件の引用
Nutrition research (New …
2024
1 件の引用
Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment.
Review
The Proceedings of …
2023
27 件の引用
Nutrients
2023
12 件の引用
BMC nutrition
2023
10 件の引用
Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2.
Observational
Alzheimer's & dementia …
2023
7 件の引用
Clinical nutrition (Edinburgh, …
2022
87 件の引用
Journal of Alzheimer's …
2022
4 件の引用
The American journal …
2021
70 件の引用
Dietary Lutein and Cognitive Function in Adults: A Meta-Analysis of Randomized Controlled Trials.
Meta-Analysis
Molecules (Basel, Switzerland)
2021
26 件の引用
Journal of nutritional …
2021
26 件の引用
Nutrition research (New …
2021
17 件の引用
Nutritional neuroscience
2020
72 件の引用
The Journal of …
2020
47 件の引用
Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals.
RCT
Nutrients
2020
43 件の引用
Scientific reports
2019
6 件の引用
Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study.
Observational
Neurology
2018
159 件の引用
Journal of the …
2018
76 件の引用
Journal of Alzheimer's …
2018
63 件の引用
Journal of the …
2018
43 件の引用
Nutricion hospitalaria
2018
32 件の引用
Pharmacological research
2018
26 件の引用
Free radical biology …
2017
37 件の引用
Frontiers in aging …
2017
28 件の引用
Frontiers in aging …
2016
32 件の引用
The British journal …
2015
62 件の引用
Zhonghua yu fang …
2015
4 件の引用
Neurobiology of aging
2014
98 件の引用
Journal of aging …
2013
253 件の引用
Nutrition journal
2013
26 件の引用
Alzheimer disease and …
2011
52 件の引用
Nutritional neuroscience
2008
277 件の引用
Journal of Alzheimer's …
2008
104 件の引用
Asia Pacific journal …
2002
24 件の引用
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
一般的な使用量
- general:
- 10-20 mg lutein + 2-4 mg zeaxanthin/day
- cognitivesupport:
- 12 mg lutein + zeaxanthin/day
上限量： Not established; 20 mg/day well-tolerated
研究で検討された用量
| 用量 | 期間 | 効果 | N |
|---|---|---|---|
| >=112 mg/day vs <112 mg/day | 270 weeks | Positive | 1550 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 72 |
| None | -- | Mixed | -- |
| None | -- | Positive | 60 |
| None | 156 weeks | Positive | 442 |
| MIND, Mediterranean, DASH, HEI-2015 diets | -- | Positive | -- |
推奨摂取タイミング： With meals containing fat
Safety & Side Effects
報告されている副作用
- ⚠ Generally very well-tolerated
- ⚠ Mild skin yellowing at very high doses (carotenodermia, harmless)
既知の相互作用
- ● Orlistat (reduces carotenoid absorption)
- ● Cholesterol-lowering drugs (may reduce absorption)
耐容上限摂取量： Not established; 20 mg/day well-tolerated
サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
Frequently Asked Questions
Does Lutein & Zeaxanthin help with Age-Related Cognitive Decline?
Based on 8 studies with 600 participants, there is limited but promising evidence that Lutein & Zeaxanthin may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Lutein & Zeaxanthin should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 10-20 mg lutein + 2-4 mg zeaxanthin/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lutein & Zeaxanthin?
Reported side effects may include Generally very well-tolerated, Mild skin yellowing at very high doses (carotenodermia, harmless). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lutein & Zeaxanthin and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
に関する他の成分： Age-Related Cognitive Decline
References
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