Lutein & Zeaxanthin для Age-Related Cognitive Decline
C Доказательства Доказательства ограничены небольшими исследованиями, однако имеются некоторые положительные сигналы.A 6-month RCT showed macular xanthophylls increased serum BDNF, reduced IL-1beta, and improved composite memory, psychomotor speed, and sustained attention. Macular pigment optical density correlates with cognitive performance.
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C
Итог
A 6-month RCT showed macular xanthophylls increased serum BDNF, reduced IL-1beta, and improved composite memory, psychomotor speed, and sustained attention. Macular pigment optical density correlates with cognitive performance.
Key Study Findings
Cohort Study
n=1550
270 weeks
Low Intake of Total Antioxidant Nutrients as a Risk Factor for Incident Dementia in Older …
Dose: >=112 mg/day vs <112 mg/day
или: Low AN intake (<112 mg/day)
Outcome: Incident dementia
Эффект: HR 1.87 (95% CI 1.26-2.77)
None
Популяция: Community residents without dementia aged >=60 years
In Vitro
Construction and In Vitro Evaluation of Brain-Targeted Lutein Liposomes.
Dose: None
или: Free lutein
Outcome: BBB permeability and lutein stability
Эффект: 22.73% BBB permeability at 12h
None
Популяция: In vitro BBB model and stability tests
Review
Carotenoids for Antiaging: Nutraceutical, Pharmaceutical, and Cosmeceutical Applications.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: systematic review of carotenoids for antiaging (nutraceutical, pharmaceutical, cosmeceutical)
Observational Study
n=72
Association of Habitual Diet Quality and Nutrient Intake with Cognitive Performance in Community-Dwelling Older Adults: …
Dose: None
или: None
Outcome: Cognitive performance (CERAD battery)
Эффект: None
0.007 (fiber), 0.004 (K)
Популяция: Community-dwelling older adults aged 65+
Review
Therapeutic Potentials of the Seaweed-Derived Compounds for Alzheimer's Disease.
Dose: None
или: None
Outcome: None
Эффект: None
None
Популяция: None
Observational Study
n=60
Vascular Roads to a Healthier Brain: Lutein Moderates the Influence of Arterial Stiffness on Cognitive …
Dose: None
или: None
Outcome: Carotenoid moderation of cfPWV-cognition relationship
Эффект: Beta=0.53, p=0.04 for lutein moderation
0.02
Популяция: Adults, mean age 38.6, 70% female
Key Statistics
8
Исследования
600
Участники
↑
Positive
C
Оценка
Referenced Papers
Pharmaceuticals (Basel, Switzerland)
2025
28 цитирований
The American journal …
2025
2 цитирований
Neuroepidemiology
2025
1 цитирований
Foods (Basel, Switzerland)
2025
1 цитирований
The Journal of …
2025
Molecules (Basel, Switzerland)
2025
Nutrients
2025
International journal of …
2024
11 цитирований
International journal of …
2024
4 цитирований
Nutricion hospitalaria
2024
4 цитирований
Journal of Alzheimer's …
2024
1 цитирований
Nutrition research (New …
2024
1 цитирований
Sustaining an ageing population: the role of micronutrients in frailty and cognitive impairment.
Review
The Proceedings of …
2023
27 цитирований
Nutrients
2023
12 цитирований
BMC nutrition
2023
10 цитирований
Dietary nutrient intake and cognitive function in the Age-Related Eye Disease Studies 1 and 2.
Observational
Alzheimer's & dementia …
2023
7 цитирований
Clinical nutrition (Edinburgh, …
2022
87 цитирований
Journal of Alzheimer's …
2022
4 цитирований
The American journal …
2021
70 цитирований
Dietary Lutein and Cognitive Function in Adults: A Meta-Analysis of Randomized Controlled Trials.
Meta-Analysis
Molecules (Basel, Switzerland)
2021
26 цитирований
Journal of nutritional …
2021
26 цитирований
Nutrition research (New …
2021
17 цитирований
Nutritional neuroscience
2020
72 цитирований
The Journal of …
2020
47 цитирований
Effects of Matcha Green Tea Powder on Cognitive Functions of Community-Dwelling Elderly Individuals.
RCT
Nutrients
2020
43 цитирований
Scientific reports
2019
6 цитирований
Nutrients and bioactives in green leafy vegetables and cognitive decline: Prospective study.
Observational
Neurology
2018
159 цитирований
Journal of the …
2018
76 цитирований
Journal of Alzheimer's …
2018
63 цитирований
Journal of the …
2018
43 цитирований
Nutricion hospitalaria
2018
32 цитирований
Pharmacological research
2018
26 цитирований
Free radical biology …
2017
37 цитирований
Frontiers in aging …
2017
28 цитирований
Frontiers in aging …
2016
32 цитирований
The British journal …
2015
62 цитирований
Zhonghua yu fang …
2015
4 цитирований
Neurobiology of aging
2014
98 цитирований
Journal of aging …
2013
253 цитирований
Nutrition journal
2013
26 цитирований
Alzheimer disease and …
2011
52 цитирований
Nutritional neuroscience
2008
277 цитирований
Journal of Alzheimer's …
2008
104 цитирований
Asia Pacific journal …
2002
24 цитирований
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Часто используемые дозировки
- general:
- 10-20 mg lutein + 2-4 mg zeaxanthin/day
- cognitivesupport:
- 12 mg lutein + zeaxanthin/day
Верхний предел: Not established; 20 mg/day well-tolerated
Дозировки, изученные в исследованиях
| Дозировка | Длительность | Эффект | N |
|---|---|---|---|
| >=112 mg/day vs <112 mg/day | 270 weeks | Positive | 1550 |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | 72 |
| None | -- | Mixed | -- |
| None | -- | Positive | 60 |
| None | 156 weeks | Positive | 442 |
| MIND, Mediterranean, DASH, HEI-2015 diets | -- | Positive | -- |
Лучшее время приёма: With meals containing fat
Safety & Side Effects
Зарегистрированные побочные эффекты
- ⚠ Generally very well-tolerated
- ⚠ Mild skin yellowing at very high doses (carotenodermia, harmless)
Известные взаимодействия
- ● Orlistat (reduces carotenoid absorption)
- ● Cholesterol-lowering drugs (may reduce absorption)
Допустимый верхний уровень потребления: Not established; 20 mg/day well-tolerated
Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
Frequently Asked Questions
Does Lutein & Zeaxanthin help with Age-Related Cognitive Decline?
Based on 8 studies with 600 participants, there is limited but promising evidence that Lutein & Zeaxanthin may support Age-Related Cognitive Decline management. Our evidence grade is C (Some Evidence).
How much Lutein & Zeaxanthin should I take for Age-Related Cognitive Decline?
Studies have used various dosages. A commonly studied range is 10-20 mg lutein + 2-4 mg zeaxanthin/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Lutein & Zeaxanthin?
Reported side effects may include Generally very well-tolerated, Mild skin yellowing at very high doses (carotenodermia, harmless). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Lutein & Zeaxanthin and Age-Related Cognitive Decline?
We rate the evidence as Grade C (Some Evidence). This rating is based on 8 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
Related Evidence
Другие ингредиенты для Age-Related Cognitive Decline
References
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