Omega-3 Fatty Acids (DHA/EPA) ： Cerebrovascular Health

Q: Does Omega-3 Fatty Acids (DHA/EPA) help with Cerebrovascular Health?

Based on 12 studies with 2,000 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Cerebrovascular Health management. Our evidence grade is B (Good Evidence).

Q: How much Omega-3 Fatty Acids (DHA/EPA) should I take for Cerebrovascular Health?

Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?

Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Cerebrovascular Health?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

DHA supports vascular endothelial function and may help reduce neuroinflammation. In CAD patients, 3.36 g/day supplementation was associated with slowed cognitive aging equivalent to approximately 2.5 years.

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結論

Key Study Findings

Review

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …

Dose: None vs: None Outcome: None 効果: None None

対象集団: narrative review of ashwagandha clinical trials and basic research (1994-present)

Other 10 weeks

Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of …

Dose: None vs: Untreated APP/PS1 mice Outcome: Cognitive performance in behavioral tests 効果: None None

対象集団: APP/PS1 transgenic Alzheimer's disease mouse model

Review

Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines.

Dose: None vs: None Outcome: ASD symptom management 効果: None None

対象集団: Children with autism spectrum disorder

Cohort Study n=215624

Neuroticism, omega-3 fatty acids, and risk of incident dementia.

Dose: None vs: None Outcome: Incident all-cause dementia 効果: None <0.05 (Bonferroni)

対象集団: Dementia-free UK Biobank participants aged 40-69

preclinical animal/in vitro study

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …

Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs: Placebo 効果: None None

Other 26 weeks

Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk.

Dose: EPA 180mg + DHA 120mg vs: Simulated disease population baseline Outcome: Lipid biomarker changes (in silico model) 効果: 14.7% TG reduction, 22.38% HDL increase None

対象集団: Simulated CVD disease population (in silico study)

Key Statistics

研究数

2000

参加者数

↑

Positive

グレード

Referenced Papers

The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. Review

Nutrients 2026

Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … Other

Journal of ethnopharmacology 2025 9 件の引用

Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies. Review

Frontiers in nutrition 2025 7 件の引用

Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of Alzheimer's disease. Other

Phytomedicine : international … 2025 6 件の引用

Coenzyme Q10 and Cognition: A Review. Review

Nutrients 2025 2 件の引用

Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines. Review

Alternative therapies in … 2025

Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk. Other

Scientific reports 2025

Neuroticism, omega-3 fatty acids, and risk of incident dementia. Other

Journal of affective … 2025

Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants. Review

Degenerative neurological and … 2024 66 件の引用

[Not Available]. Review

Acta pharmaceutica Sinica. … 2024 33 件の引用

Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … Meta-Analysis

European journal of … 2024 16 件の引用

Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy. Other

Biomedicines 2024 3 件の引用

[Pharmacotherapies for insomnia]. Other

La Revue du … 2024

Lipids at the Nexus between Cerebrovascular Disease and Vascular Dementia: The Impact of HDL-Cholesterol and Ceramides. Review

International journal of … 2023 23 件の引用

trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis. Other

Research (Washington, D.C.) 2022 38 件の引用

Glucosinolates and Omega-3 Fatty Acids from Mustard Seeds: Phytochemistry and Pharmacology. Review

Plants (Basel, Switzerland) 2022 26 件の引用

Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … Other

Preventive nutrition and … 2022 18 件の引用

Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase. Other

Journal of cellular … 2022 15 件の引用

Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging. Meta-Analysis

NeuroImage. Clinical 2022 14 件の引用

A Novel Combination of High-Load Omega-3 Lysine Complex (AvailOm®) and Anthocyanins Exerts Beneficial Cardiovascular Effects. Other

Antioxidants (Basel, Switzerland) 2022 10 件の引用

Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its … Other

Journal of ethnopharmacology 2022 8 件の引用

Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial. Other

BMJ open 2022 3 件の引用

Comments on "dose-related meta-analysis for omega-3 fatty acids supplementation on major adverse cardiovascular events". Other

Clinical nutrition (Edinburgh, … 2022 1 件の引用

Restless legs syndrome. Review

Nature reviews. Disease … 2021 163 件の引用

Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … Other

Journal of ethnopharmacology 2021 69 件の引用

DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease. Other

The American journal … 2021 25 件の引用

The Clinical Efficacy of Ginkgo biloba Leaf Preparation on Ischemic Stroke: A Systematic Review and Meta-Analysis. Review

Evidence-based complementary and … 2021 24 件の引用

Fish consumption, long-chain omega-3 fatty acids intake and risk of stroke: An updated systematic review and meta-analysis. Meta-Analysis

Asia Pacific journal … 2021 16 件の引用

Characterization of pharmaco-EEG fingerprint and sleep-wake profiles of Lavandula angustifolia Mill. essential oil inhalation and diazepam administration in rats. Other

Journal of ethnopharmacology 2021 16 件の引用

Online Promotion of "Brain Health" Supplements. Other

The Senior care … 2021 2 件の引用

Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. RCT

EBioMedicine 2020 107 件の引用

Neurodegenerative diseases and Withania somnifera (L.): An update. Review

Journal of ethnopharmacology 2020 85 件の引用

Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity. RCT

The Journal of … 2020 33 件の引用

Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. Systematic Review

Journal of integrative … 2020 33 件の引用

The Veterans Administration and Department of Defense clinical practice guidelines for the diagnosis and management of sleep disorders: what does … Other

Journal of clinical … 2020 17 件の引用

Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Review

South African medical … 2020 5 件の引用

[Similarities and differences between Ginkgo biloba and Panax notoginseng in treatment of ischemic cerebrovascular disease]. Other

Zhongguo Zhong yao … 2020 3 件の引用

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and … Review

Revue neurologique 2019 361 件の引用

Multiple Health Benefits and Minimal Risks Associated with Vegetarian Diets. Review

Current nutrition reports 2019 68 件の引用

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. RCT

Journal of psychiatric … 2019 46 件の引用

Sleep Disorders in Wilson's Disease. Review

Current neurology and … 2019 11 件の引用

Effects of Omega-3 Fatty Acids on Resting Cerebral Perfusion in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. RCT

The journal of … 2018 24 件の引用

Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults. Other

Frontiers in aging … 2018 23 件の引用

Brain imaging and networks in restless legs syndrome. Review

Sleep medicine 2017 95 件の引用

Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. Review

The journal of … 2017 75 件の引用

Treatment of Sleep Dysfunction in Parkinson's Disease. Review

Current treatment options … 2017 56 件の引用

Review of Safety and Efficacy of Sleep Medicines in Older Adults. Review

Clinical therapeutics 2016 328 件の引用

DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … RCT

Nutrients 2016 53 件の引用

Associations of dietary polychlorinated biphenyls and long-chain omega-3 fatty acids with stroke risk. Other

Environment international 2016 24 件の引用

Concurrent Use of Low-Dose Aspirin and Omega-3 Fatty Acids and Risk of Upper Gastrointestinal Complications: A Cohort Study with Nested … Other

Basic & clinical … 2016 5 件の引用

Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. Other

Molecular nutrition & … 2015 18 件の引用

The Beyond Ageing Project Phase 2--a double-blind, selective prevention, randomised, placebo-controlled trial of omega-3 fatty acids and sertraline in an … RCT

Trials 2015 17 件の引用

Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer's disease. Other

Neurobiology of aging 2014 73 件の引用

Baseline plasma fatty acids profile and incident cardiovascular events in the SU.FOL.OM3 trial: the evidence revisited. RCT

PloS one 2014 22 件の引用

[The effects of Omega-3 fatty acids in clinical medicine]. Review

Praxis 2014 1 件の引用

[Atrial fibrillation after coronary artery bypass surgery: possibilities of prevention]. Review

Srpski arhiv za … 2012 3 件の引用

Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. Review

Journal of clinical … 2011 396 件の引用

Alternative drug therapies for dementia. Other

Journal of psychosocial … 2011 26 件の引用

OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted … RCT

Circulation 2010 593 件の引用

Can nutrients prevent or delay onset of Alzheimer's disease? Review

Journal of Alzheimer's … 2010 110 件の引用

Normal cognitive decline or dementia? Other

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The potential role of nutritional components in the management of Alzheimer's Disease. Review

European journal of … 2008 49 件の引用

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Anesthesia and analgesia 2004 127 件の引用

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Rural and remote … 2004 14 件の引用

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The Cochrane database … 2003 263 件の引用

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Actions of Ginkgo Biloba related to potential utility for the treatment of conditions involving cerebral hypoxia. Review

Life sciences 2000 41 件の引用

Influence of diethyl maleate and cysteine on tissue glutathione and growth in broiler chickens. Other

Poultry science 1995 16 件の引用

Dietary omega-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries. Other

Stroke 1992 25 件の引用

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

一般的な使用量

general:: 1,000-2,000 mg combined DHA/EPA per day
cognitivesupport:: 1,000-1,700 mg/day (optimal dose-response curve)

上限量： 3,000 mg/day combined DHA/EPA (FDA GRAS)

研究で検討された用量

用量	期間	効果	N
None	--	Positive	--
None	10 weeks	Positive	--
None	--	Positive	--
None	--	Positive	215624
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL	--	Positive	--
EPA 180mg + DHA 120mg	26 weeks	Positive	--
None	--	Mixed	--
None	--	Mixed	--

推奨摂取タイミング： With meals containing fat for better absorption

Safety & Side Effects

報告されている副作用

⚠ Fishy aftertaste or burping
⚠ Mild gastrointestinal discomfort
⚠ Potential increased bleeding time at very high doses
⚠ May lower blood pressure slightly

既知の相互作用

● Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
● Blood pressure medications (additive hypotensive effect)
● Orlistat (may reduce omega-3 absorption)

耐容上限摂取量： 3,000 mg/day combined DHA/EPA (FDA GRAS)

サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。

Frequently Asked Questions

Does Omega-3 Fatty Acids (DHA/EPA) help with Cerebrovascular Health?

Based on 12 studies with 2,000 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Cerebrovascular Health management. Our evidence grade is B (Good Evidence).

How much Omega-3 Fatty Acids (DHA/EPA) should I take for Cerebrovascular Health?

Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?

Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Cerebrovascular Health?

We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

Related Evidence

に関する他の成分： Cerebrovascular Health

Ginkgo biloba B Resveratrol C

Omega-3 Fatty Acids (DHA/EPA) 他の症状・状態について

Age-Related Cognitive Decline A Mild Cognitive Impairment (MCI) B Depression-Related Cognitive Dysfunction B Attention & Focus Difficulties C

総合評価

Evidence Strength72%

High confidence

研究の内訳

RCT (8)Meta (3)Other (1)

代替成分との比較

この症状に対する他の成分との比較をご覧ください。

に関するすべての成分を見る： Cerebrovascular Health

詳しく見る

FDAに関する免責事項: これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。