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Omega-3 Fatty Acids (DHA/EPA) for Cerebrovascular Health

B Good Evidence At least one randomized trial supports this, with mostly consistent results.

DHA supports vascular endothelial function and may help reduce neuroinflammation. In CAD patients, 3.36 g/day supplementation was associated with slowed cognitive aging equivalent to approximately 2.5 years.

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B

The Bottom Line

DHA supports vascular endothelial function and may help reduce neuroinflammation. In CAD patients, 3.36 g/day supplementation was associated with slowed cognitive aging equivalent to approximately 2.5 years.

Key Study Findings

Review
The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A …
Dose: None vs: None Outcome: None Effect: None None

Population: narrative review of ashwagandha clinical trials and basic research (1994-present)

Other 26 weeks
Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk.
Dose: EPA 180mg + DHA 120mg vs: Simulated disease population baseline Outcome: Lipid biomarker changes (in silico model) Effect: 14.7% TG reduction, 22.38% HDL increase None

Population: Simulated CVD disease population (in silico study)

preclinical animal/in vitro study
Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice …
Dose: 60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL vs: Placebo Effect: None None
Review
Coenzyme Q10 and Cognition: A Review.
Dose: None vs: None Outcome: None Effect: None None

Population: Review of CoQ10 supplementation and cognition

Other 10 weeks
Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of …
Dose: None vs: Untreated APP/PS1 mice Outcome: Cognitive performance in behavioral tests Effect: None None

Population: APP/PS1 transgenic Alzheimer's disease mouse model

Key Statistics

12

Studies

2000

Participants

Positive

B

Grade

Referenced Papers

Nutrients 2025 2 citations
Acta pharmaceutica Sinica. … 2024 33 citations
La Revue du … 2024
Nature reviews. Disease … 2021 163 citations
The Senior care … 2021 2 citations
Journal of ethnopharmacology 2020 85 citations
Current neurology and … 2019 11 citations
Sleep medicine 2017 95 citations
Current treatment options … 2017 56 citations
Clinical therapeutics 2016 328 citations
Journal of psychosocial … 2011 26 citations
Journal of Alzheimer's … 2010 110 citations
The Practitioner 2010
The Cochrane database … 2003 263 citations
The Medical clinics … 2002 59 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Commonly Used Dosages

general:
1,000-2,000 mg combined DHA/EPA per day
cognitivesupport:
1,000-1,700 mg/day (optimal dose-response curve)

Upper limit: 3,000 mg/day combined DHA/EPA (FDA GRAS)

Dosages Studied in Research

Dosage Duration Effect N
None -- Positive --
EPA 180mg + DHA 120mg 26 weeks Positive --
60 and 100 mg/kg (mice); 100 and 200 µg/mL (HT-22 cells); withanolide A 1.56 and 3.12 µg/mL -- Positive --
None -- Mixed --
None -- Mixed --
None 10 weeks Positive --
None -- Positive --
None -- Positive 215624

Best taken: With meals containing fat for better absorption

Safety & Side Effects

Reported Side Effects

  • Fishy aftertaste or burping
  • Mild gastrointestinal discomfort
  • Potential increased bleeding time at very high doses
  • May lower blood pressure slightly

Known Interactions

  • Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
  • Blood pressure medications (additive hypotensive effect)
  • Orlistat (may reduce omega-3 absorption)

Tolerable upper intake: 3,000 mg/day combined DHA/EPA (FDA GRAS)

Always consult your healthcare provider before starting any supplement.

Frequently Asked Questions

Does Omega-3 Fatty Acids (DHA/EPA) help with Cerebrovascular Health?
Based on 12 studies with 2,000 participants, there is moderate evidence from clinical studies that Omega-3 Fatty Acids (DHA/EPA) may support Cerebrovascular Health management. Our evidence grade is B (Good Evidence).
How much Omega-3 Fatty Acids (DHA/EPA) should I take for Cerebrovascular Health?
Studies have used various dosages. A commonly studied range is 1,000-2,000 mg combined DHA/EPA per day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Omega-3 Fatty Acids (DHA/EPA)?
Reported side effects may include Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May lower blood pressure slightly. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Omega-3 Fatty Acids (DHA/EPA) and Cerebrovascular Health?
We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 2,000 total participants. The overall direction of effect is positive.

References

  1. [1] Kaj Winther. Nutrients. 2026. The Clinical Implications of Ashwagandha (Withania somnifera L.) with a Special Reference to Side Effects-A Review. doi:10.3390/nu18050871 PubMed
  2. [2] Hyeongyeong Kim et al.. J Ethnopharmacol. 2025. Ashwagandha (Withania somnifera (L.) dunal) root extract containing withanolide a alleviates depression-like behavior in mice by enhancing the brain-derived neurotrophic … doi:10.1016/j.jep.2024.119224 PubMed
  3. [3] Apeksha Rana et al.. Front Nutr. 2025. Natural sulfur compounds in mental health and neurological disorders: insights from observational and intervention studies. doi:10.3389/fnut.2025.1534000 PubMed
  4. [4] Ting Yu et al.. Phytomedicine. 2025. Ginkgo biloba Extract GBE50 ameliorates cerebrovascular dysfunction and cognitive impairment in a mouse model of Alzheimer's disease. doi:10.1016/j.phymed.2025.156646 PubMed
  5. [5] Madeleine C Nankivell et al.. Nutrients. 2025. Coenzyme Q10 and Cognition: A Review. doi:10.3390/nu17172896 PubMed
  6. [6] Nasser M Aldekhail et al.. Altern Ther Health Med. 2025. Herbal Medicines in Autism Spectrum Disorder: Therapeutic Potential, Plant Components, and Dosage Guidelines. PubMed
  7. [7] Sanjaay Balakrishnan et al.. Sci Rep. 2025. Systems biology modelling based evaluation of omega-3 formulation in managing cardiovascular and cerebrovascular risk. doi:10.1038/s41598-025-23677-6 PubMed
  8. [8] Yaqing Gao et al.. J Affect Disord. 2025. Neuroticism, omega-3 fatty acids, and risk of incident dementia. doi:10.1016/j.jad.2025.119733 PubMed
  9. [9] Prabhash Nath Tripathi et al.. Degener Neurol Neuromuscul Dis. 2024. Review of Pharmacotherapeutic Targets in Alzheimer's Disease and Its Management Using Traditional Medicinal Plants. doi:10.2147/DNND.S452009 PubMed
  10. [10] Weile Ye et al.. Acta Pharm Sin B. 2024. [Not Available]. doi:10.1016/j.apsb.2023.09.014 PubMed
  11. [11] Jing Chang et al.. Eur J Nutr. 2024. Effects of vitamins and polyunsaturated fatty acids on cognitive function in older adults with mild cognitive impairment: a meta-analysis of … doi:10.1007/s00394-024-03324-y PubMed
  12. [12] Christa M Frodella et al.. Biomedicines. 2024. Oxytocin and Vasopressin Gene Expression in the Brain as Potential Biomarkers for Cannabidiol Therapeutic Efficacy. doi:10.3390/biomedicines12061273 PubMed
  13. [13] Marie-Françoise Vecchierini et al.. Rev Prat. 2024. [Pharmacotherapies for insomnia]. PubMed
  14. [14] Domenico Sergi et al.. Int J Mol Sci. 2023. Lipids at the Nexus between Cerebrovascular Disease and Vascular Dementia: The Impact of HDL-Cholesterol and Ceramides. doi:10.3390/ijms24054403 PubMed
  15. [15] Jinxuan Wang et al.. Research (Wash D C). 2022. trans-2-Enoyl-CoA Reductase Tecr-Driven Lipid Metabolism in Endothelial Cells Protects against Transcytosis to Maintain Blood-Brain Barrier Homeostasis. doi:10.34133/2022/9839368 PubMed
  16. [16] Gitishree Das et al.. Plants (Basel). 2022. Glucosinolates and Omega-3 Fatty Acids from Mustard Seeds: Phytochemistry and Pharmacology. doi:10.3390/plants11172290 PubMed
  17. [17] Sindgi Vasudeva Murthy et al.. Prev Nutr Food Sci. 2022. Hydroalcoholic Extract of Ashwagandha Improves Sleep by Modulating GABA/Histamine Receptors and EEG Slow-Wave Pattern in In Vitro - In Vivo … doi:10.3746/pnf.2022.27.1.108 PubMed
  18. [18] Lucille M Yanckello et al.. J Cell Immunol. 2022. Inulin Supplementation Mitigates Gut Dysbiosis and Brain Impairment Induced by Mild Traumatic Brain Injury during Chronic Phase. doi:10.33696/immunology.4.132 PubMed
  19. [19] Vincent Beliveau et al.. Neuroimage Clin. 2022. Revisiting brain iron deficiency in restless legs syndrome using magnetic resonance imaging. doi:10.1016/j.nicl.2022.103024 PubMed
  20. [20] Paola Di Pietro et al.. Antioxidants (Basel). 2022. A Novel Combination of High-Load Omega-3 Lysine Complex (AvailOm®) and Anthocyanins Exerts Beneficial Cardiovascular Effects. doi:10.3390/antiox11050896 PubMed
  21. [21] Misato Ota et al.. J Ethnopharmacol. 2022. Prolonging effects of Valeriana fauriei root extract on pentobarbital-induced sleep in caffeine-induced insomnia model mice and the pharmacokinetics of its … doi:10.1016/j.jep.2022.115625 PubMed
  22. [22] Yulin Sun et al.. BMJ Open. 2022. Melatonin supplementation for the treatment of infantile spasms: protocol for a randomised placebo-controlled triple-blind trial. doi:10.1136/bmjopen-2021-057970 PubMed
  23. [23] Jannis Kountouras et al.. Clin Nutr. 2022. Comments on "dose-related meta-analysis for omega-3 fatty acids supplementation on major adverse cardiovascular events". doi:10.1016/j.clnu.2022.06.015 PubMed
  24. [24] Mauro Manconi et al.. Nat Rev Dis Primers. 2021. Restless legs syndrome. doi:10.1038/s41572-021-00311-z PubMed
  25. [25] Heba M A Khalil et al.. J Ethnopharmacol. 2021. Ashwagandha (Withania somnifera) root extract attenuates hepatic and cognitive deficits in thioacetamide-induced rat model of hepatic encephalopathy via induction of … doi:10.1016/j.jep.2021.114141 PubMed
  26. [26] Aleix Sala-Vila et al.. Am J Clin Nutr. 2021. DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease. doi:10.1093/ajcn/nqab016 PubMed
  27. [27] Shuang Zhao et al.. Evid Based Complement Alternat Med. 2021. The Clinical Efficacy of Ginkgo biloba Leaf Preparation on Ischemic Stroke: A Systematic Review and Meta-Analysis. doi:10.1155/2021/4265219 PubMed
  28. [28] Chen Chen et al.. Asia Pac J Clin Nutr. 2021. Fish consumption, long-chain omega-3 fatty acids intake and risk of stroke: An updated systematic review and meta-analysis. doi:10.6133/apjcn.202103_30(1).0017 PubMed
  29. [29] Rodiya Manor et al.. J Ethnopharmacol. 2021. Characterization of pharmaco-EEG fingerprint and sleep-wake profiles of Lavandula angustifolia Mill. essential oil inhalation and diazepam administration in rats. doi:10.1016/j.jep.2021.114193 PubMed
  30. [30] Brittany R Block et al.. Sr Care Pharm. 2021. Online Promotion of "Brain Health" Supplements. doi:10.4140/TCP.n.2021.489 PubMed
  31. [31] Isabella C Arellanes et al.. EBioMedicine. 2020. Brain delivery of supplemental docosahexaenoic acid (DHA): A randomized placebo-controlled clinical trial. doi:10.1016/j.ebiom.2020.102883 PubMed
  32. [32] Nawab John Dar et al.. J Ethnopharmacol. 2020. Neurodegenerative diseases and Withania somnifera (L.): An update. doi:10.1016/j.jep.2020.112769 PubMed
  33. [33] Julia C Kuszewski et al.. J Nutr. 2020. Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity. doi:10.1093/jn/nxaa299 PubMed
  34. [34] Noriko Shinjyo et al.. J Integr Med. 2020. Berberine for prevention of dementia associated with diabetes and its comorbidities: A systematic review. doi:10.1016/j.joim.2020.01.004 PubMed
  35. [35] Jennifer L Martin et al.. J Clin Sleep Med. 2020. The Veterans Administration and Department of Defense clinical practice guidelines for the diagnosis and management of sleep disorders: what does … doi:10.5664/jcsm.8486 PubMed
  36. [36] A Jaca et al.. S Afr Med J. 2020. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. doi:10.7196/SAMJ.2020.v110i12.14730 PubMed
  37. [37] Dan Wu et al.. Zhongguo Zhong Yao Za Zhi. 2020. [Similarities and differences between Ginkgo biloba and Panax notoginseng in treatment of ischemic cerebrovascular disease]. doi:10.19540/j.cnki.cjcmm.20200313.402 PubMed
  38. [38] G C Román et al.. Rev Neurol (Paris). 2019. Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and … doi:10.1016/j.neurol.2019.08.005 PubMed
  39. [39] Jason P Rocha et al.. Curr Nutr Rep. 2019. Multiple Health Benefits and Minimal Risks Associated with Vegetarian Diets. doi:10.1007/s13668-019-00298-w PubMed
  40. [40] Jerome Sarris et al.. J Psychiatr Res. 2019. L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial. doi:10.1016/j.jpsychires.2018.12.014 PubMed
  41. [41] Valérie Cochen De Cock et al.. Curr Neurol Neurosci Rep. 2019. Sleep Disorders in Wilson's Disease. doi:10.1007/s11910-019-1001-4 PubMed
  42. [42] C Schwarz et al.. J Prev Alzheimers Dis. 2018. Effects of Omega-3 Fatty Acids on Resting Cerebral Perfusion in Patients with Mild Cognitive Impairment: A Randomized Controlled Trial. doi:10.14283/jpad.2017.23 PubMed
  43. [43] Jeffery M Reddan et al.. Front Aging Neurosci. 2018. Glycerophospholipid Supplementation as a Potential Intervention for Supporting Cerebral Structure in Older Adults. doi:10.3389/fnagi.2018.00049 PubMed
  44. [44] Giovanni Rizzo et al.. Sleep Med. 2017. Brain imaging and networks in restless legs syndrome. doi:10.1016/j.sleep.2016.07.018 PubMed
  45. [45] G Iolascon et al.. J Nutr Health Aging. 2017. Are Dietary Supplements and Nutraceuticals Effective for Musculoskeletal Health and Cognitive Function? A Scoping Review. doi:10.1007/s12603-016-0823-x PubMed
  46. [46] Amy W Amara et al.. Curr Treat Options Neurol. 2017. Treatment of Sleep Dysfunction in Parkinson's Disease. doi:10.1007/s11940-017-0461-6 PubMed
  47. [47] Jennifer L Schroeck et al.. Clin Ther. 2016. Review of Safety and Efficacy of Sleep Medicines in Older Adults. doi:10.1016/j.clinthera.2016.09.010 PubMed
  48. [48] Philippa A Jackson et al.. Nutrients. 2016. DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older … doi:10.3390/nu8020086 PubMed
  49. [49] Maria Kippler et al.. Environ Int. 2016. Associations of dietary polychlorinated biphenyls and long-chain omega-3 fatty acids with stroke risk. doi:10.1016/j.envint.2016.07.012 PubMed
  50. [50] Giuseppe Roberto et al.. Basic Clin Pharmacol Toxicol. 2016. Concurrent Use of Low-Dose Aspirin and Omega-3 Fatty Acids and Risk of Upper Gastrointestinal Complications: A Cohort Study with Nested … doi:10.1111/bcpt.12454 PubMed
  51. [51] Yoan Cherasse et al.. Mol Nutr Food Res. 2015. Zinc-containing yeast extract promotes nonrapid eye movement sleep in mice. doi:10.1002/mnfr.201500082 PubMed
  52. [52] Nicole L Cockayne et al.. Trials. 2015. The Beyond Ageing Project Phase 2--a double-blind, selective prevention, randomised, placebo-controlled trial of omega-3 fatty acids and sertraline in an … doi:10.1186/s13063-015-0762-6 PubMed
  53. [53] Valerio Zerbi et al.. Neurobiol Aging. 2014. Multinutrient diets improve cerebral perfusion and neuroprotection in a murine model of Alzheimer's disease. doi:10.1016/j.neurobiolaging.2013.09.038 PubMed
  54. [54] Léopold K Fezeu et al.. PLoS One. 2014. Baseline plasma fatty acids profile and incident cardiovascular events in the SU.FOL.OM3 trial: the evidence revisited. doi:10.1371/journal.pone.0092548 PubMed
  55. [55] Martin F Reiner et al.. Praxis (Bern 1994). 2014. [The effects of Omega-3 fatty acids in clinical medicine]. doi:10.1024/1661-8157/a001593 PubMed
  56. [56] Biljana Obrenović-Kirćanski et al.. Srp Arh Celok Lek. 2012. [Atrial fibrillation after coronary artery bypass surgery: possibilities of prevention]. doi:10.2298/sarh1208521o PubMed
  57. [57] Mark C Houston. J Clin Hypertens (Greenwich). 2011. Role of mercury toxicity in hypertension, cardiovascular disease, and stroke. doi:10.1111/j.1751-7176.2011.00489.x PubMed
  58. [58] Robert H Howland. J Psychosoc Nurs Ment Health Serv. 2011. Alternative drug therapies for dementia. doi:10.3928/02793695-20110407-03 PubMed
  59. [59] Bernhard Rauch et al.. Circulation. 2010. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted … doi:10.1161/CIRCULATIONAHA.110.948562 PubMed
  60. [60] Patrick J G H Kamphuis et al.. J Alzheimers Dis. 2010. Can nutrients prevent or delay onset of Alzheimer's disease? doi:10.3233/JAD-2010-091558 PubMed
  61. [61] Klaus P Ebmeier. Practitioner. 2010. Normal cognitive decline or dementia? PubMed
  62. [62] Eline M van der Beek et al.. Eur J Pharmacol. 2008. The potential role of nutritional components in the management of Alzheimer's Disease. doi:10.1016/j.ejphar.2008.01.049 PubMed
  63. [63] Anna K Morin et al.. Pharmacotherapy. 2007. Therapeutic options for sleep-maintenance and sleep-onset insomnia. doi:10.1592/phco.27.1.89 PubMed
  64. [64] Akhlaq A Farooqui et al.. Brain Res Rev. 2007. Comparison of biochemical effects of statins and fish oil in brain: the battle of the titans. doi:10.1016/j.brainresrev.2007.09.004 PubMed
  65. [65] Chun-Su Yuan et al.. Anesth Analg. 2004. The gamma-aminobutyric acidergic effects of valerian and valerenic acid on rat brainstem neuronal activity. doi:10.1213/01.ANE.0000096189.70405.A5 PubMed
  66. [66] H V Thommasen et al.. Rural Remote Health. 2004. Differences in diabetic co-morbidity between Aboriginal and non-Aboriginal people living in Bella Coola, Canada. PubMed
  67. [67] M Malouf et al.. Cochrane Database Syst Rev. 2003. Folic acid with or without vitamin B12 for cognition and dementia. doi:10.1002/14651858.CD004514 PubMed
  68. [68] Lauren T Bonner et al.. Med Clin North Am. 2002. Pharmacologic treatments of dementia. doi:10.1016/s0025-7125(02)00007-x PubMed
  69. [69] S Logani et al.. Life Sci. 2000. Actions of Ginkgo Biloba related to potential utility for the treatment of conditions involving cerebral hypoxia. doi:10.1016/s0024-3205(00)00741-4 PubMed
  70. [70] B Enkvetchakul et al.. Poult Sci. 1995. Influence of diethyl maleate and cysteine on tissue glutathione and growth in broiler chickens. doi:10.3382/ps.0740864 PubMed
  71. [71] P Kim et al.. Stroke. 1992. Dietary omega-3 fatty acids and endothelium-dependent responses in porcine cerebral arteries. doi:10.1161/01.str.23.3.407 PubMed

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.