The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review.

Anas Anas Sohail, Fernando Ortiz, Teresa Varghese, Stephanie P Fabara, Arshdeep S Batth et al.

Review Cureus 2021 20 citations

<\/script>\n

`; }, get iframeSnippet() { const domain = 'braincited.com'; const params = 'pmid\u003D35111479'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

Study Design

Study Type: Systematic Review
Population: None
Duration: 884 weeks

Intervention: The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review. 9.4%
Comparator: None
Primary Outcome: None
Effect Direction: Positive
Risk of Bias: Unclear

Abstract

Attention-deficit hyperactivity disorder (ADHD) affects multiple cognitive domains, including impaired attention, hyperactivity, and increased impulsivity. According to the CDC, 9.4% of children between 2 and 17 years old have been diagnosed with ADHD. Neurotransmitters such as noradrenaline and dopamine have been suggested as crucial players in the pathophysiology of ADHD and are often targets of modern medication. Adenosine receptors types A1 and A2a in the brain are inhibited by caffeine: a stimulant known to augment attention by increasing cholinergic and dopaminergic transmission. The cognitive function of attention is also enhanced by the amino acid: L-theanine. The mechanism of action is that it behaves like a glutamate reuptake inhibitor while also acting in the hippocampus as a competitive low-affinity glutamate receptor antagonist. It's also shown to have a neuroprotective effect by its action on the gamma aminobutyric acid (GABA)-A receptors. Our systematic review investigates the literature and clinical trials on the cognitive-enhancing effects of caffeine and L-theanine.

TL;DR

A systematic review investigates the literature and clinical trials on the cognitive-enhancing effects of caffeine and L-theanine on the pathophysiology of ADHD and shows that caffeine has a neuroprotective effect.

Used In Evidence Reviews

B L-Theanine for Attention & Focus Difficulties

The Cognitive-Enhancing Outcomes of Caffeine and L-theanine: A Systematic Review.

Embed This Widget

Study Design

Abstract

TL;DR

Used In Evidence Reviews

Similar Papers

Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study.

The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial.

L-theanine in the adjunctive treatment of generalized anxiety disorder: A double-blind, randomised, placebo-controlled trial.

Effects of L-theanine-caffeine combination on sustained attention and inhibitory control among children with ADHD: a proof-of-concept neuroimaging RCT.

The effects of L-theanine supplementation on the outcomes of patients with mental disorders: a systematic review.

Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study.