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Folate для Nutritional Deficiency Cognitive Impairment

B

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

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B

Итог

Critical for homocysteine metabolism and SAM production essential for neurotransmitter synthesis. MTHFR polymorphism carriers may benefit more from methylated forms (5-MTHF).

Key Study Findings

Observational Study n=2582
Relationship Between Serum Vitamins and Cognitive Impairment in the Elderly: A Study Based on the …
Dose: None или: None Outcome: Cognitive impairment risk Эффект: OR=0.695 (Vit D); OR=0.777 (FA) p=0.003 (Vit D); p=0.034 (FA)

Популяция: Elderly participants aged 60+ from NHANES 2011-2014

Cross-Sectional Study n=1966
Folate mediates cognitive impairment of aged people with periodontitis.
Dose: None или: Placebo Эффект: Mediation proportion: dietary supplement folate 8.4%; serum total folate 9.1%; RBC folate 9.1% None
Review
B-vitamins and one-carbon metabolism during pregnancy: health impacts and challenges.
Dose: None или: None Outcome: Pregnancy outcomes and offspring neurodevelopment Эффект: None None

Популяция: Pregnant women (review)

Meta-Analysis
Associations between Diet and Cognitive Function in Stroke Survivors: A Systematic Review and Meta-analysis.
Dose: None или: Standard care or placebo Outcome: Global cognition in stroke survivors Эффект: SMD=0.62 (energy-protein); SMD=-0.40 (B-vitamins) 0.009 (protein); 0.02 (B-vit)

Популяция: Adult stroke survivors (20 trials + 14 observational)

Other
Fresh Genetic Insights Into Micronutrients Influences on Restless Legs Syndrome Risk.
Dose: None или: None Outcome: Causal association of micronutrients with RLS Эффект: Retinol OR 0.46; Mg OR 0.62 None

Популяция: European ancestry (7248 RLS cases, 19802 controls)

Randomized Controlled Trial Double-blind
Relationships of B12 and Homocysteine with Outcomes in the SURE-PD, SURE-PD3, and STEADY-PDIII Trials.
Dose: Vitamin B12 (measured, not supplemented) или: Within-trial comparison Outcome: B12/homocysteine association with PD outcomes Эффект: None None

Популяция: Early Parkinson's disease patients

Key Statistics

10

Исследования

1500

Участники

Positive

B

Оценка

Referenced Papers

The Proceedings of … 2025 5 цитирований
Nutritional neuroscience 2025 1 цитирований
Food and nutrition … 2024 19 цитирований
Nutrients 2023 9 цитирований
Nutrition and health 2021 13 цитирований
The Senior care … 2021 2 цитирований
Systematic reviews 2020 29 цитирований
Journal of Alzheimer's … 2018 281 цитирований
Ginekologia polska 2015 7 цитирований
European journal of … 2012 225 цитирований
Evidence report/technology assessment 2006
The Cochrane database … 2003 263 цитирований
Current opinion in … 1998 30 цитирований

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Часто используемые дозировки

general:
400 mcg DFE/day (RDA)
cognitivesupport:
400-800 mcg/day

Верхний предел: 1,000 mcg/day from supplements (may mask B12 deficiency)

Дозировки, изученные в исследованиях

Дозировка Длительность Эффект N
None -- Positive 2582
None -- Positive 1966
None -- Positive --
None -- Mixed --
None -- Mixed --
Vitamin B12 (measured, not supplemented) -- Positive --
None -- Positive --
>5 mg/day -- Negative --

Лучшее время приёма: With or without food; morning preferred

Safety & Side Effects

Зарегистрированные побочные эффекты

  • Generally well-tolerated
  • May mask B12 deficiency symptoms
  • Rare: insomnia or irritability at high doses

Известные взаимодействия

  • Methotrexate (antagonist — folate reduces efficacy)
  • Anticonvulsants (phenytoin, carbamazepine — mutual interference)
  • Sulfasalazine (reduces folate absorption)

Допустимый верхний уровень потребления: 1,000 mcg/day from supplements (may mask B12 deficiency)

Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.

Frequently Asked Questions

Does Folate help with Nutritional Deficiency Cognitive Impairment?
Based on 10 studies with 1,500 participants, there is moderate evidence from clinical studies that Folate may support Nutritional Deficiency Cognitive Impairment management. Our evidence grade is B (Good Evidence).
How much Folate should I take for Nutritional Deficiency Cognitive Impairment?
Studies have used various dosages. A commonly studied range is 400 mcg DFE/day (RDA). Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Folate?
Reported side effects may include Generally well-tolerated, May mask B12 deficiency symptoms, Rare: insomnia or irritability at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Folate and Nutritional Deficiency Cognitive Impairment?
We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 1,500 total participants. The overall direction of effect is positive.

Related Evidence

Другие ингредиенты для Nutritional Deficiency Cognitive Impairment

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